{"id":"https://openalex.org/W2052546226","doi":"https://doi.org/10.1097/nrl.0000000000000013","title":"Physical Activity Level and Future Risk of Mild Cognitive Impairment or Dementia","display_name":"Physical Activity Level and Future Risk of Mild Cognitive Impairment or Dementia","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W2052546226","doi":"https://doi.org/10.1097/nrl.0000000000000013","mag":"2052546226","pmid":"https://pubmed.ncbi.nlm.nih.gov/25692517"},"language":"en","primary_location":{"id":"doi:10.1097/nrl.0000000000000013","doi":"https://doi.org/10.1097/nrl.0000000000000013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/nrl.0000000000000013","pdf_url":null,"source":{"id":"https://openalex.org/S135892068","display_name":"The Neurologist","issn_l":"1074-7931","issn":["1074-7931","2331-2637"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Neurologist","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110817693","display_name":"Gretchen E. Schlosser Covell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gretchen E. Schlosser Covell","raw_affiliation_strings":["*Department of Neurology \u2020Department of Library Services, Division of Education Administration \u2021Department of Psychiatry, Mayo Clinic, Scottsdale, AZ and Phoenix, AZ","Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Neurology \u2020Department of Library Services, Division of Education Administration \u2021Department of Psychiatry, Mayo Clinic, Scottsdale, AZ and Phoenix, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Department of Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103483819","display_name":"Charlene R. Hoffman\u2010Snyder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Charlene R. Hoffman-Snyder","raw_affiliation_strings":["Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082395750","display_name":"Kay E. Wellik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kay E. Wellik","raw_affiliation_strings":["Department of Library Services, Division of Education Administration"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Library Services, Division of Education Administration","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068423077","display_name":"Bryan Keith Woodruff","orcid":"https://orcid.org/0000-0002-4728-7294","observed_orcids":["https://orcid.org/0000-0002-4728-7294"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bryan K. Woodruff","raw_affiliation_strings":["Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058106909","display_name":"Yonas E. Geda","orcid":"https://orcid.org/0000-0003-1187-7230","observed_orcids":["https://orcid.org/0000-0003-1187-7230"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yonas E. Geda","raw_affiliation_strings":["Department of Neurology","Department of Psychiatry, Mayo Clinic, Scottsdale, AZ and Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry, Mayo Clinic, Scottsdale, AZ and Phoenix, AZ","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074086871","display_name":"Richard J. Caselli","orcid":"https://orcid.org/0000-0001-5784-2987","observed_orcids":["https://orcid.org/0000-0001-5784-2987"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Richard J. Caselli","raw_affiliation_strings":["Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034553945","display_name":"Bart M. Demaerschalk","orcid":"https://orcid.org/0000-0001-7262-817X","observed_orcids":["https://orcid.org/0000-0001-7262-817X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bart M. Demaerschalk","raw_affiliation_strings":["Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008002660","display_name":"Dean M. Wingerchuk","orcid":"https://orcid.org/0000-0003-1608-8206","observed_orcids":["https://orcid.org/0000-0003-1608-8206"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dean M. Wingerchuk","raw_affiliation_strings":["Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008002660","https://openalex.org/A5034553945","https://openalex.org/A5058106909","https://openalex.org/A5068423077","https://openalex.org/A5074086871","https://openalex.org/A5103483819"],"corresponding_institution_ids":["https://openalex.org/I4210125099"],"apc_list":null,"apc_paid":null,"fwci":4.7091,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.9503112,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"3","first_page":"89","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":1.0},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.8399999737739563},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/actigraphy","display_name":"actigraphy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/objective-physical-activity-measurement","display_name":"objective physical activity measurement","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.6320000290870667},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5080000162124634},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7894195318222046},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.686837911605835},{"id":"https://openalex.org/C2778996325","wikidata":"https://www.wikidata.org/wiki/Q422201","display_name":"Actigraphy","level":3,"score":0.6327099800109863},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5653451085090637},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5441766977310181},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5144810676574707},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5085741281509399},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4545038342475891},{"id":"https://openalex.org/C98559332","wikidata":"https://www.wikidata.org/wiki/Q492762","display_name":"Recall bias","level":2,"score":0.43047022819519043},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4294695556163788},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4273626506328583},{"id":"https://openalex.org/C134011695","wikidata":"https://www.wikidata.org/wiki/Q2699874","display_name":"Neuropsychiatry","level":2,"score":0.4103953242301941},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.39747491478919983},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.38538485765457153},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.32212668657302856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14943644404411316},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09209150075912476},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/nrl.0000000000000013","doi":"https://doi.org/10.1097/nrl.0000000000000013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/nrl.0000000000000013","pdf_url":null,"source":{"id":"https://openalex.org/S135892068","display_name":"The Neurologist","issn_l":"1074-7931","issn":["1074-7931","2331-2637"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Neurologist","raw_type":"journal-article"},{"id":"pmid:25692517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25692517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The neurologist","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1989476860","https://openalex.org/W1999429226","https://openalex.org/W2052792956","https://openalex.org/W2072164919","https://openalex.org/W2077119043","https://openalex.org/W2079338106","https://openalex.org/W2091159443","https://openalex.org/W2105024128","https://openalex.org/W2107658105","https://openalex.org/W2139751847","https://openalex.org/W2142514276","https://openalex.org/W2164133449"],"related_works":["https://openalex.org/W2168165272","https://openalex.org/W3173160675","https://openalex.org/W2034526967","https://openalex.org/W2804900164","https://openalex.org/W2062394981","https://openalex.org/W2980928873","https://openalex.org/W2097903222","https://openalex.org/W1995284005","https://openalex.org/W7118068614","https://openalex.org/W4295007468"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,84],"relationships":[2],"between":[3,69],"physical":[4,29,56,159,192],"activity,":[5,160],"cognition,":[6],"and":[7,20,49,54,74,116,123,131,134,218,222],"development":[8,90],"of":[9,15,28,91,146,158,172,191,199,203,216],"neurodegenerative":[10],"diseases":[11],"represent":[12],"an":[13],"area":[14],"intense":[16],"research":[17],"interest.":[18],"Meta-analyses":[19],"prospective":[21],"cohort":[22,144],"studies":[23,208],"show":[24],"that":[25,44,188],"greater":[26,189],"levels":[27,157,190],"activity":[30,57,73,193],"are":[31,45,194,209],"associated":[32,167,195],"with":[33,168,196],"lower":[34,170],"dementia":[35],"risk.":[36],"Most":[37],"studies,":[38],"however,":[39],"depend":[40],"on":[41],"self-report":[42],"data":[43,58],"subject":[46],"to":[47,211],"recall":[48],"other":[50],"biases.":[51],"Obtaining":[52],"objective":[53,85],"quantitative":[55],"could":[59],"strengthen":[60],"observational":[61],"study":[62,145],"validity.":[63],"OBJECTIVE:":[64],"To":[65],"examine":[66],"the":[67,89,213,224],"association":[68,215],"objectively":[70],"measured":[71,162],"daytime":[72],"mild":[75],"cognitive":[76,220],"impairment":[77],"(MCI)":[78],"or":[79,175,205],"Alzheimer":[80],"disease":[81],"(AD).":[82],"METHODS:":[83],"was":[86],"addressed":[87],"through":[88],"a":[92,99,104,128,141,169,200],"structured,":[93],"critically":[94],"appraised":[95],"topic.":[96],"We":[97,139],"incorporated":[98],"clinical":[100,126],"scenario,":[101],"background":[102],"information,":[103],"structured":[105],"question,":[106],"literature":[107],"search":[108],"strategy,":[109],"critical":[110],"appraisal,":[111],"results,":[112],"evidence":[113],"summary,":[114],"commentary,":[115],"bottom":[117],"line":[118],"conclusions.":[119],"Participants":[120],"included":[121],"consultant":[122],"resident":[124],"neurologists,":[125],"epidemiologists,":[127],"medical":[129],"librarian,":[130],"behavioral":[132],"neurology":[133],"neuropsychiatry":[135],"content":[136],"experts.":[137],"RESULTS:":[138],"selected":[140],"prospective,":[142],"single-center":[143],"716":[147],"cognitively":[148],"normal":[149],"elderly":[150],"participants":[151],"followed":[152],"for":[153],"3.5":[154],"years.":[155],"Greater":[156],"as":[161],"using":[163],"wrist":[164],"actigraphy,":[165],"were":[166],"risk":[171,198],"incident":[173],"MCI":[174,204],"AD":[176],"(hazard":[177],"ratio,":[178],"0.477;":[179],"95%":[180],"confidence":[181],"interval,":[182],"0.273-0.832).":[183],"CONCLUSIONS:":[184],"Objective":[185],"measurement":[186],"confirms":[187],"decreased":[197],"future":[201,219],"diagnosis":[202],"AD.":[206],"Further":[207],"needed":[210],"confirm":[212],"temporal":[214],"exercise":[217],"health":[221],"understand":[223],"relevant":[225],"underlying":[226],"biological":[227],"mechanisms.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}