{"id":"https://openalex.org/W205250026","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1127","title":"Abstract 4992: Cardiovascular Disease Risk Prediction with and without Knowledge of Genetic Variation at Chromosome 9p21.3: The Women\u2019s Genome Health Study","display_name":"Abstract 4992: Cardiovascular Disease Risk Prediction with and without Knowledge of Genetic Variation at Chromosome 9p21.3: The Women\u2019s Genome Health Study","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W205250026","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1127","mag":"205250026"},"language":"en","primary_location":{"id":"doi:10.1161/circ.118.suppl_18.s_1127","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1127","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1127","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003186890","display_name":"Nina P. Paynter","orcid":"https://orcid.org/0000-0003-3376-3867","observed_orcids":["https://orcid.org/0000-0003-3376-3867"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nina P Paynter","raw_affiliation_strings":["Brigham and Women\u2019s Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013920089","display_name":"Daniel I. Chasman","orcid":"https://orcid.org/0000-0003-3357-0862","observed_orcids":["https://orcid.org/0000-0003-3357-0862"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel I Chasman","raw_affiliation_strings":["Brigham and Women\u2019s Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090744975","display_name":"Julie E. Buring","orcid":"https://orcid.org/0000-0003-2648-8692","observed_orcids":["https://orcid.org/0000-0003-2648-8692"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie E Buring","raw_affiliation_strings":["Brigham and Women\u2019s Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032073217","display_name":"Dov Shiffman","orcid":"https://orcid.org/0000-0002-1845-7397","observed_orcids":["https://orcid.org/0000-0002-1845-7397","https://orcid.org/0009-0002-8255-1174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dov Shiffman","raw_affiliation_strings":["Celera, Alameda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celera, Alameda, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084857746","display_name":"Nancy R. Cook","orcid":"https://orcid.org/0000-0002-9705-0842","observed_orcids":["https://orcid.org/0000-0002-9705-0842"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy R Cook","raw_affiliation_strings":["Brigham and Women\u2019s Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091595592","display_name":"Paul M. Ridker","orcid":"https://orcid.org/0000-0003-1249-4522","observed_orcids":["https://orcid.org/0000-0003-1249-4522"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M Ridker","raw_affiliation_strings":["Brigham and Women\u2019s Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14212","display_name":"Health Promotion and Cardiovascular Prevention","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chromosome-9p21-3","display_name":"chromosome 9p21.3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rs10757274","display_name":"rs10757274","score":0.9919999837875366},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8790000081062317},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5},{"id":"https://openalex.org/keywords/risk-reclassification","display_name":"risk reclassification","score":0.7049999833106995},{"id":"https://openalex.org/keywords/c-index","display_name":"concordance index","score":0.40799999237060547},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.8050000071525574},{"id":"https://openalex.org/keywords/family-history-of-myocardial-infarction","display_name":"family history of myocardial infarction","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8849683403968811},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7121958136558533},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5621706247329712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5423163175582886},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5422074198722839},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5184423923492432},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4652844965457916},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45454782247543335},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.45009666681289673},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4335392415523529},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43005549907684326},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33240288496017456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28967559337615967},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1503516435623169},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.12398329377174377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11406654119491577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06325125694274902}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.118.suppl_18.s_1127","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_1127","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_1127","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2124191974","https://openalex.org/W1978089955","https://openalex.org/W2007939005","https://openalex.org/W2273441544","https://openalex.org/W2161063097","https://openalex.org/W2068626203","https://openalex.org/W2132128500","https://openalex.org/W2139822721","https://openalex.org/W1984499236","https://openalex.org/W69779785"],"abstract_inverted_index":{"Background":[0],":":[1,63,146,267],"While":[2],"genetic":[3,276],"variation":[4,33,277],"at":[5,34],"chromosome":[6,35,92,279],"9p21.3":[7,36,93,280],"is":[8,16],"associated":[9,151,282],"with":[10,152,220,283],"incident":[11,84,159,284],"cardiovascular":[12],"disease":[13],"(CVD),":[14],"it":[15],"unclear":[17],"whether":[18,30],"screening":[19],"for":[20,83,89,127,148,158,168,185],"this":[21,269],"polymorphism":[22],"improves":[23],"risk":[24,44,136,209],"prediction.":[25],"We":[26,86],"sought":[27],"to":[28,38,139,142,196,206,218,232,256],"determine":[29],"knowledge":[31],"of":[32,53,80,104,114,133,161,175,192,203,223,244,273,293],"adds":[37],"the":[39,59,69,124,169,176,186,193,197,201,204,215,228,253],"information":[40],"provided":[41],"by":[42],"traditional":[43,207],"factors":[45,210],"using":[46,123],"data":[47],"from":[48],"a":[49,78],"prospective":[50,271],"cohort":[51,272],"study":[52],"female":[54],"Caucasian":[55,274],"health":[56],"professionals":[57],"in":[58,68,91,173,190,278],"United":[60],"States.":[61],"Methods":[62],"22,129":[64],"initially":[65],"healthy":[66],"participants":[67],"Women\u2019s":[70],"Genome":[71],"Health":[72],"Study":[73],"were":[74,120,263],"prospectively":[75],"followed":[76],"over":[77],"median":[79],"10.2":[81],"years":[82],"CVD.":[85],"determined":[87],"genotype":[88,171,188,205,229],"rs10757274":[90,149],"as":[94,96],"well":[95],"blood":[97,102],"pressure,":[98],"smoking":[99],"status,":[100],"diabetes,":[101],"levels":[103],"cholesterol,":[105],"high":[106],"sensitivity":[107],"C-reactive":[108],"protein":[109],"(hsCRP),":[110],"and":[111,126,178,241,258],"family":[112,242],"history":[113,243],"premature":[115,245],"myocardial":[116],"infarction":[117],"(MI).":[118],"Models":[119],"compared":[121,195],"overall":[122],"C-index":[125,216,254],"reclassification":[128,222],"across":[129],"commonly":[130],"used":[131],"categories":[132],"10-year":[134],"CVD":[135,160,208,285],"(<5%,":[137],"5%":[138],"<10%,":[140],"10%":[141],"<20%,":[143],"20+%).":[144],"Results":[145],"Genotype":[147],"was":[150,230,248,281],"an":[153],"adjusted":[154],"hazard":[155],"ratio":[156],"(HR)":[157],"1.25":[162],"(95%":[163,180],"CI":[164,181],"1.04":[165],"\u2013":[166,183],"1.51)":[167],"AG":[170],"(present":[172,189],"49%":[174],"women)":[177,194],"1.32":[179],"1.07":[182],"1.63)":[184],"GG":[187],"24%":[191],"AA":[198],"genotype.":[199],"However,":[200],"addition":[202],"had":[211],"no":[212,250],"effect":[213,251],"on":[214,252],"(0.805":[217],"0.807)":[219],"correct":[221],"526":[224],"women":[225,261],"(2.4%).":[226],"When":[227],"added":[231],"previously":[233],"validated":[234],"prediction":[235],"models":[236],"that":[237],"additionally":[238],"included":[239],"hsCRP":[240],"MI,":[246],"there":[247],"again":[249],"(0.809":[255],"0.807),":[257],"only":[259],"214":[260],"(1.0%)":[262],"reclassified":[264],"correctly.":[265],"Conclusion":[266],"In":[268],"large":[270],"women,":[275],"but":[286],"did":[287],"not":[288],"improve":[289],"discrimination":[290],"or":[291],"classification":[292],"predicted":[294],"risk.":[295]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}