{"id":"https://openalex.org/W2052467994","doi":"https://doi.org/10.1074/jbc.m202807200","title":"STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration","display_name":"STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2052467994","doi":"https://doi.org/10.1074/jbc.m202807200","mag":"2052467994","pmid":"https://pubmed.ncbi.nlm.nih.gov/12032149"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m202807200","doi":"https://doi.org/10.1074/jbc.m202807200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202807200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m202807200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA","From the Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"From the Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041119082","display_name":"Xianping Liang","orcid":"https://orcid.org/0009-0009-1324-5270","observed_orcids":["https://orcid.org/0009-0009-1324-5270"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianping Liang","raw_affiliation_strings":["From the Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030446532","display_name":"Christoph Kellendonk","orcid":"https://orcid.org/0000-0003-3302-2188","observed_orcids":["https://orcid.org/0000-0003-3302-2188"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Kellendonk","raw_affiliation_strings":["Center for Neurobiology and Behavior, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurobiology and Behavior, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019791912","display_name":"Valeria Poli","orcid":"https://orcid.org/0000-0002-3739-3966","observed_orcids":["https://orcid.org/0000-0002-3739-3966"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Valeria Poli","raw_affiliation_strings":["Dipartimento di Genetica, Biologia e Biochimica, Via Santena 5 bis, 10126 Torino, Italy","School of Life Sciences, Wellcome Trust Biocenter, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Genetica, Biologia e Biochimica, Via Santena 5 bis, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"School of Life Sciences, Wellcome Trust Biocenter, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114115410","display_name":"Rebecca A. Taub","orcid":"https://orcid.org/0000-0003-4509-7005","observed_orcids":["https://orcid.org/0000-0003-4509-7005"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rebecca Taub","raw_affiliation_strings":["From the Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Genetics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5114115410"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":9.7572,"has_fulltext":false,"cited_by_count":307,"citation_normalized_percentile":{"value":0.98203215,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"277","issue":"32","first_page":"28411","last_page":"28417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8610000014305115},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.890999972820282},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.6819999814033508},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hepatocyte-dna-synthesis","display_name":"hepatocyte DNA synthesis","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.75954270362854},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6618822813034058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5624156594276428},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5390177965164185},{"id":"https://openalex.org/C195521686","wikidata":"https://www.wikidata.org/wiki/Q17152676","display_name":"Liver cytology","level":3,"score":0.4212051331996918},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4176662266254425},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3446221947669983},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.3015434145927429},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2629832625389099},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10297086834907532}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m202807200","doi":"https://doi.org/10.1074/jbc.m202807200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202807200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12032149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12032149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/42914","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/42914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m202807200","doi":"https://doi.org/10.1074/jbc.m202807200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202807200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G364489099","display_name":null,"funder_award_id":"DK 58315","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6157254165","display_name":"THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM","funder_award_id":"R01DK058315","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8243034","display_name":null,"funder_award_id":"P30DK50306","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000909123","display_name":"Center for Molecular Studies in Digestive and Liver Diseases","funder_award_id":"P30DK050306","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W70902317","https://openalex.org/W127609430","https://openalex.org/W159302622","https://openalex.org/W1564799350","https://openalex.org/W1865279351","https://openalex.org/W1973596639","https://openalex.org/W1974968368","https://openalex.org/W1977176665","https://openalex.org/W1981799488","https://openalex.org/W2001713238","https://openalex.org/W2002186586","https://openalex.org/W2010648922","https://openalex.org/W2012628280","https://openalex.org/W2013279950","https://openalex.org/W2014237818","https://openalex.org/W2025421728","https://openalex.org/W2029275361","https://openalex.org/W2029312116","https://openalex.org/W2031156245","https://openalex.org/W2032674547","https://openalex.org/W2035134361","https://openalex.org/W2043493252","https://openalex.org/W2053451732","https://openalex.org/W2055209830","https://openalex.org/W2056961869","https://openalex.org/W2070242833","https://openalex.org/W2073002157","https://openalex.org/W2074356752","https://openalex.org/W2076822857","https://openalex.org/W2083802827","https://openalex.org/W2086715846","https://openalex.org/W2094111001","https://openalex.org/W2106219094","https://openalex.org/W2114838652","https://openalex.org/W2122076953","https://openalex.org/W2122506044","https://openalex.org/W2129274801","https://openalex.org/W2129362876","https://openalex.org/W2132633540","https://openalex.org/W2135055828","https://openalex.org/W2147028876","https://openalex.org/W2163775914","https://openalex.org/W2167978531","https://openalex.org/W2173560213","https://openalex.org/W2247149472","https://openalex.org/W4211173486","https://openalex.org/W4285719527","https://openalex.org/W4313333868","https://openalex.org/W4313347835"],"related_works":["https://openalex.org/W2090563155","https://openalex.org/W32599780","https://openalex.org/W2076822857","https://openalex.org/W2054439577","https://openalex.org/W2058046583","https://openalex.org/W2141991930","https://openalex.org/W2970782573","https://openalex.org/W2275683267","https://openalex.org/W2089019762","https://openalex.org/W2025421728"],"abstract_inverted_index":{"STAT3":[0,26,37,56,68,79,88,107,178,241],"is":[1,15,227],"rapidly":[2],"induced":[3],"during":[4,39,190],"liver":[5,19,31,62,70,191],"regeneration":[6,32],"in":[7,58,69,84,95,100,106,118,135,150,165,208,237],"an":[8,45,170],"interleukin":[9],"6":[10],"(IL-6)-dependent":[11],"fashion,":[12],"and":[13,159,246],"IL-6":[14,223],"required":[16,29],"for":[17,30,180,197],"normal":[18],"regeneration.":[20,71],"We":[21],"wanted":[22],"to":[23,53,63,124,147,173],"know":[24],"whether":[25],"was":[27,51,76,92,104,122],"also":[28,93],"but":[33,143],"disruption":[34],"of":[35,67,127,182,187,200,204,219,222],"the":[36,59,65,128,183,188,205,213,220,235],"gene":[38,137],"embryonic":[40],"stages":[41],"causes":[42],"lethality.":[43],"Therefore,":[44,177],"albumin":[46],"promoter-driven":[47],"Cre-loxP":[48],"recombination":[49],"system":[50],"used":[52],"create":[54],"a":[55],"deletion":[57],"adult":[60],"mouse":[61],"study":[64,233],"role":[66],"After":[72],"partial":[73],"hepatectomy,":[74],"there":[75],"virtually":[77],"no":[78],"RNA":[80],"or":[81],"protein":[82],"induction":[83,199],"Alb(+)":[85,96,119,130,166,209],"STAT3(fl/fl)":[86,97,120,131,167,210],"livers.":[87,98,152],"DNA":[89,112,184],"binding":[90],"activity":[91],"absent":[94],"Unlike":[99],"control":[101],"livers,":[102,168],"STAT1":[103],"activated":[105],"conditional-mutant":[108],"livers":[109,121,132,211],"posthepatectomy.":[110],"Hepatocyte":[111],"synthesis":[113],"at":[114,216],"40":[115],"h":[116],"posthepatectomy":[117],"reduced":[123],"approximately":[125],"one-third":[126],"control.":[129],"had":[133,161],"abnormalities":[134],"immediate-early":[136],"activation":[138,203],"that":[139,215,240],"largely":[140],"correlated":[141],"with":[142],"were":[144],"not":[145,228],"identical":[146],"those":[148],"seen":[149],"IL-6-/-":[151],"G(1)":[153,172],"phase":[154,175],"cyclins":[155,157],"including":[156],"D1":[158],"E":[160],"lower":[162],"expression":[163],"levels":[164],"indicating":[169],"abnormal":[171],"S":[174],"transition.":[176],"accounts":[179],"part":[181,218],"synthetic":[185],"response":[186],"hepatocytes":[189],"regeneration,":[192],"which":[193],"cannot":[194],"be":[195],"compensated":[196],"by":[198,230],"STAT1.":[201],"Normal":[202],"MAPK":[206],"pathway":[207],"reinforces":[212],"fact":[214],"least":[217],"effect":[221],"on":[224],"hepatocyte":[225],"proliferation":[226,248],"mediated":[229],"STAT3.":[231],"This":[232],"provides":[234],"first":[236],"vivo":[238],"evidence":[239],"promotes":[242],"cell":[243,247],"cycle":[244],"progression":[245],"under":[249],"physiological":[250],"growth":[251],"conditions.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":23}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}