{"id":"https://openalex.org/W2052460032","doi":"https://doi.org/10.1056/nejm198202113060606","title":"Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir","display_name":"Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir","publication_year":1982,"publication_date":"1982-02-11","ids":{"openalex":"https://openalex.org/W2052460032","doi":"https://doi.org/10.1056/nejm198202113060606","mag":"2052460032","pmid":"https://pubmed.ncbi.nlm.nih.gov/6275267"},"language":"en","primary_location":{"id":"doi:10.1056/nejm198202113060606","doi":"https://doi.org/10.1056/nejm198202113060606","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198202113060606","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082691948","display_name":"Clyde S. Crumpacker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clyde S. Crumpacker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111692212","display_name":"Lowell E. Schnipper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lowell E. Schnipper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060622311","display_name":"Steven I. Marlowe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven I. Marlowe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054209856","display_name":"Patricia N. Kowalsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia N. Kowalsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008644268","display_name":"Brenda J. Hershey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brenda J. Hershey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051264386","display_name":"Myron J. Levin","orcid":"https://orcid.org/0000-0002-7468-106X","observed_orcids":["https://orcid.org/0000-0002-7468-106X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myron J. Levin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":45.0314,"has_fulltext":false,"cited_by_count":346,"citation_normalized_percentile":{"value":0.99946708,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"306","issue":"6","first_page":"343","last_page":"346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.8809999823570251},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.843999981880188},{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":0.9769999980926514},{"id":"https://openalex.org/keywords/brivudine","display_name":"BvDU","score":0.7129999995231628},{"id":"https://openalex.org/keywords/varicella-zoster-virus","display_name":"varicella-zoster virus","score":0.8159999847412109},{"id":"https://openalex.org/keywords/thymidine-kinase","display_name":"thymidine kinase","score":0.8560000061988831},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.8714610934257507},{"id":"https://openalex.org/C2776147627","wikidata":"https://www.wikidata.org/wiki/Q24783855","display_name":"Thymidine kinase","level":4,"score":0.8594273328781128},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7206953167915344},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6674186587333679},{"id":"https://openalex.org/C2776159415","wikidata":"https://www.wikidata.org/wiki/Q6868","display_name":"Varicella zoster virus","level":3,"score":0.6476441621780396},{"id":"https://openalex.org/C2779450786","wikidata":"https://www.wikidata.org/wiki/Q147101","display_name":"Aciclovir","level":5,"score":0.6149519085884094},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5705764889717102},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.559462308883667},{"id":"https://openalex.org/C2780452071","wikidata":"https://www.wikidata.org/wiki/Q418594","display_name":"Valaciclovir","level":5,"score":0.5064188241958618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4941549599170685},{"id":"https://openalex.org/C2777111502","wikidata":"https://www.wikidata.org/wiki/Q419140","display_name":"Deoxyuridine","level":3,"score":0.48010018467903137},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.4786985218524933},{"id":"https://openalex.org/C2778260397","wikidata":"https://www.wikidata.org/wiki/Q419861","display_name":"Bromodeoxyuridine","level":3,"score":0.4753522574901581},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.4509838819503784},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4223603904247284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30243557691574097},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.1499599814414978},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13418957591056824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12751057744026184},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.11625844240188599},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11079701781272888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm198202113060606","doi":"https://doi.org/10.1056/nejm198202113060606","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198202113060606","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:6275267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6275267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8621000051498413,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1964359729","https://openalex.org/W1982144414","https://openalex.org/W1984444755","https://openalex.org/W1993169474","https://openalex.org/W2019678244","https://openalex.org/W2026396393","https://openalex.org/W2031610597","https://openalex.org/W2035091776","https://openalex.org/W2045360603","https://openalex.org/W2052424460","https://openalex.org/W2075883417","https://openalex.org/W2081586257","https://openalex.org/W2104796719","https://openalex.org/W2114240169","https://openalex.org/W2142992472","https://openalex.org/W2152264576","https://openalex.org/W2159818060","https://openalex.org/W2333553600","https://openalex.org/W2337976486"],"related_works":["https://openalex.org/W4230124578","https://openalex.org/W195326233","https://openalex.org/W7099694988","https://openalex.org/W1978439227","https://openalex.org/W2088152779","https://openalex.org/W2055594999","https://openalex.org/W2507260691","https://openalex.org/W2052424460","https://openalex.org/W2041939667","https://openalex.org/W2300034093"],"abstract_inverted_index":{"SEVERAL":[0],"drugs":[1],"that":[2,71],"inhibit":[3,62],"the":[4,15,39,45,63,84,100],"replication":[5],"of":[6,19,32,49,65,72],"herpesvirus":[7],"in":[8],"vitro":[9],"are":[10,44],"now":[11],"being":[12],"evaluated":[13],"for":[14],"prevention":[16],"or":[17,36],"treatment":[18],"infections":[20],"with":[21],"herpes":[22,50,66],"simplex":[23,51,67],"virus":[24,52,68],"and":[25,38,69,77,91],"varicella":[26,73],"zoster":[27,74],"virus.1":[28],"2":[29],"3":[30],"Two":[31],"these":[33],"drugs,":[34],"acyclovir":[35,76],"9-[(2-hydroxyethoxy)-methyl]guanine":[37],"thymidine":[40,89],"analogue":[41],"E-5-(2-bromovinyl)-2\u2032deoxyuridine":[42],"(BVDU),":[43],"most":[46],"efficient":[47],"inhibitors":[48],"Type":[53],"1":[54],"plaque":[55],"formation":[56],"yet":[57],"described.4":[58],"5":[59],"6":[60],"To":[61],"growth":[64],"presumably":[70],"virus,":[75],"BVDU":[78],"must":[79,92],"first":[80],"be":[81,94],"phosphorylated":[82],"to":[83,99],"respective":[85,101],"monophosphates":[86],"by":[87,96],"virus-specified":[88],"kinase":[90],"then":[93],"converted":[95],"cellular":[97],"enzymes":[98],"triphosphates,":[102],".":[103,104,105]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}