{"id":"https://openalex.org/W2052442016","doi":"https://doi.org/10.1128/mcb.21.15.5142-5155.2001","title":"exo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair","display_name":"exo1-Dependent Mutator Mutations: Model System for Studying Functional Interactions in Mismatch Repair","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2052442016","doi":"https://doi.org/10.1128/mcb.21.15.5142-5155.2001","mag":"2052442016","pmid":"https://pubmed.ncbi.nlm.nih.gov/11438669","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/87239"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.21.15.5142-5155.2001","doi":"https://doi.org/10.1128/mcb.21.15.5142-5155.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.21.15.5142-5155.2001","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2052442016"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC87239/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067222747","display_name":"Neelam S. Amin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210117758","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02cn3rm21","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["BE","CH","US"],"is_corresponding":false,"raw_author_name":"Neelam S. Amin","raw_affiliation_strings":["Ludwig Institute for Cancer Research","Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine, La Jolla, California 92093-0660, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine, La Jolla, California 92093-0660, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067965123","display_name":"My-Nga Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210117758","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02cn3rm21","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["BE","CH","US"],"is_corresponding":false,"raw_author_name":"My-Nga Nguyen","raw_affiliation_strings":["Ludwig Institute for Cancer Research","Ludwig Institute for Cancer Research,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research,1","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053137144","display_name":"Scott Oh","orcid":"https://orcid.org/0000-0003-3993-4401","observed_orcids":["https://orcid.org/0000-0003-3993-4401"]},"institutions":[{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210117758","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02cn3rm21","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["BE","CH","US"],"is_corresponding":false,"raw_author_name":"Scott Oh","raw_affiliation_strings":["Ludwig Institute for Cancer Research","Ludwig Institute for Cancer Research,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research,1","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081915207","display_name":"Richard David Kolodner","orcid":"https://orcid.org/0000-0002-4806-8384","observed_orcids":["https://orcid.org/0000-0002-4806-8384"]},"institutions":[{"id":"https://openalex.org/I196064397","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05923xh51","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210117758","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02cn3rm21","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["BE","CH","US"],"is_corresponding":false,"raw_author_name":"Richard D. Kolodner","raw_affiliation_strings":["Cancer Center, University of California, San Diego School of Medicine, La Jolla, California 92093-0660","Department of Medicine","Ludwig Institute for Cancer Research","Cancer Center,#N#3#N# University of California, San Diego School of Medicine, La Jolla, California 92093-0660","Ludwig Institute for Cancer Research,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, University of California, San Diego School of Medicine, La Jolla, California 92093-0660","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I4210117758","https://openalex.org/I4210150094"]},{"raw_affiliation_string":"Cancer Center,#N#3#N# University of California, San Diego School of Medicine, La Jolla, California 92093-0660","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research,1","institution_ids":["https://openalex.org/I196064397","https://openalex.org/I4210150094"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.424,"has_fulltext":false,"cited_by_count":199,"citation_normalized_percentile":{"value":0.95958394,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"21","issue":"15","first_page":"5142","last_page":"5155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exo1","display_name":"EXO1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.859000027179718},{"id":"https://openalex.org/keywords/mlh1","display_name":"MLH1","score":0.734000027179718},{"id":"https://openalex.org/keywords/pms1","display_name":"PMS1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/msh2","display_name":"MSH2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/msh3","display_name":"MSH3","score":0.9139999747276306},{"id":"https://openalex.org/keywords/msh6","display_name":"MSH6","score":0.8529999852180481},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.9150000214576721},{"id":"https://openalex.org/keywords/genetic-screen","display_name":"genetic screen","score":0.5690000057220459},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.7739999890327454},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"mutation rate","score":0.4869999885559082},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.8817602396011353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8479493260383606},{"id":"https://openalex.org/C2779115348","wikidata":"https://www.wikidata.org/wiki/Q14911688","display_name":"MSH2","level":5,"score":0.8020008206367493},{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.7535176277160645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6601135730743408},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6404564380645752},{"id":"https://openalex.org/C2776674815","wikidata":"https://www.wikidata.org/wiki/Q14911717","display_name":"MSH6","level":5,"score":0.5795600414276123},{"id":"https://openalex.org/C2778677574","wikidata":"https://www.wikidata.org/wiki/Q18030629","display_name":"PMS2","level":5,"score":0.488827645778656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41611388325691223},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3704264461994171},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.35470741987228394}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005090","descriptor_name":"Exodeoxyribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020137","descriptor_name":"Base Pair Mismatch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.21.15.5142-5155.2001","doi":"https://doi.org/10.1128/mcb.21.15.5142-5155.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.21.15.5142-5155.2001","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmid:11438669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11438669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:87239","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC87239/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.318.8595","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.8595","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/21/15/5142.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:87239","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC87239/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000914450","display_name":"Enzymology of Mismatch Repair in Yeast","funder_award_id":"R01GM050006","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1510511218","https://openalex.org/W1526043578","https://openalex.org/W1554311327","https://openalex.org/W1600651336","https://openalex.org/W1774715425","https://openalex.org/W1840742563","https://openalex.org/W1895018249","https://openalex.org/W1906113850","https://openalex.org/W1913308298","https://openalex.org/W1913483978","https://openalex.org/W1953194129","https://openalex.org/W1985882391","https://openalex.org/W1986550053","https://openalex.org/W1988134858","https://openalex.org/W1995819860","https://openalex.org/W1997038017","https://openalex.org/W1998817763","https://openalex.org/W2002407831","https://openalex.org/W2006138916","https://openalex.org/W2008669260","https://openalex.org/W2013456924","https://openalex.org/W2013735712","https://openalex.org/W2016505307","https://openalex.org/W2017161034","https://openalex.org/W2017527347","https://openalex.org/W2018713333","https://openalex.org/W2026388436","https://openalex.org/W2036182319","https://openalex.org/W2038529419","https://openalex.org/W2044393910","https://openalex.org/W2046386929","https://openalex.org/W2049528447","https://openalex.org/W2049797540","https://openalex.org/W2055993339","https://openalex.org/W2060354616","https://openalex.org/W2063847889","https://openalex.org/W2063858982","https://openalex.org/W2064700784","https://openalex.org/W2073354632","https://openalex.org/W2075271539","https://openalex.org/W2075637141","https://openalex.org/W2076300945","https://openalex.org/W2085315842","https://openalex.org/W2091512138","https://openalex.org/W2094023740","https://openalex.org/W2096491491","https://openalex.org/W2099974826","https://openalex.org/W2110451932","https://openalex.org/W2110627805","https://openalex.org/W2110912468","https://openalex.org/W2113215973","https://openalex.org/W2119030852","https://openalex.org/W2120179554","https://openalex.org/W2121781767","https://openalex.org/W2122748184","https://openalex.org/W2123985521","https://openalex.org/W2124896165","https://openalex.org/W2125636072","https://openalex.org/W2126938336","https://openalex.org/W2127732470","https://openalex.org/W2131639139","https://openalex.org/W2133231925","https://openalex.org/W2135135381","https://openalex.org/W2136615212","https://openalex.org/W2140132110","https://openalex.org/W2140384792","https://openalex.org/W2141798197","https://openalex.org/W2142008631","https://openalex.org/W2143787623","https://openalex.org/W2145227544","https://openalex.org/W2147435086","https://openalex.org/W2147555368","https://openalex.org/W2153262927","https://openalex.org/W2153389989","https://openalex.org/W2155679230","https://openalex.org/W2161804304","https://openalex.org/W2166776471","https://openalex.org/W2167976833","https://openalex.org/W2169333620","https://openalex.org/W2170472485","https://openalex.org/W2390421705","https://openalex.org/W4246944625","https://openalex.org/W4297408474"],"related_works":["https://openalex.org/W4282919830","https://openalex.org/W3178735538","https://openalex.org/W2133231925","https://openalex.org/W2058951716","https://openalex.org/W3201336723","https://openalex.org/W2122439785","https://openalex.org/W1963602366","https://openalex.org/W6925556782","https://openalex.org/W2076046893","https://openalex.org/W3113360738"],"abstract_inverted_index":{"EXO1":[0,27,199],"interacts":[1],"with":[2,59,80,115],"MSH2":[3],"and":[4,6,52,76,96,131,165,188,206],"MLH1":[5,128],"has":[7],"been":[8],"proposed":[9,220],"to":[10,36],"be":[11,174],"a":[12,31,56,180,195,201,211],"redundant":[13],"exonuclease":[14],"that":[15,39,185],"functions":[16],"in":[17,28,68,91,127,134,162,197,204],"mismatch":[18,29],"repair":[19],"(MMR).":[20],"To":[21],"better":[22],"understand":[23],"the":[24,41,81,120,136,140,166,225],"role":[25,203,218],"of":[26,119,144,153,157,171,179,213],"repair,":[30],"genetic":[32],"screen":[33,57],"was":[34],"performed":[35],"identify":[37],"mutations":[38,48,65,88,99,121,148,158,172],"increase":[40],"mutation":[42],"rates":[43],"caused":[44,123,168],"by":[45,169,176],"weak":[46,82,102],"mutator":[47,64,87],"such":[49],"as":[50,105],"exo1Delta":[51],"pms1-A130V":[53],"mutations.":[54],"In":[55],"starting":[58,79],"an":[60,183],"exo1":[61],"mutation,":[62],"exo1-dependent":[63],"were":[66,89],"obtained":[67,122],"MLH1,":[69,92],"PMS1,":[70,130],"MSH2,":[71,93],"MSH3,":[72,94],"POL30":[73],"(PCNA),":[74],"POL32,":[75],"RNR1,":[77],"whereas":[78],"pms1":[83],"allele":[84,187],"pms1-A130V,":[85],"pms1-dependent":[86],"identified":[90],"MSH6,":[95],"EXO1.":[97],"These":[98,192],"only":[100],"cause":[101,109],"MMR":[103,111,205,214],"defects":[104,112],"single":[106],"mutants":[107],"but":[108],"strong":[110],"when":[113],"combined":[114],"each":[116],"other.":[117],"Most":[118],"amino":[124],"acid":[125],"substitutions":[126],"or":[129,139],"these":[132,145],"clustered":[133],"either":[135],"ATP-binding":[137],"region":[138],"MLH1-PMS1":[141],"interaction":[142],"regions":[143],"proteins.":[146,215],"The":[147],"showed":[149,159,186],"two":[150],"other":[151],"types":[152],"interactions:":[154],"specific":[155],"pairs":[156,170],"unlinked":[160],"noncomplementation":[161],"diploid":[163],"strains,":[164],"defect":[167],"could":[173],"suppressed":[175],"high-copy-number":[177],"expression":[178],"third":[181],"gene,":[182],"effect":[184],"overexpressed":[189],"gene":[190],"specificity.":[191],"results":[193],"support":[194],"model":[196],"which":[198],"plays":[200],"structural":[202],"stabilizes":[207],"multiprotein":[208],"complexes":[209],"containing":[210],"number":[212],"A":[216],"similar":[217],"is":[219],"for":[221],"PCNA":[222],"based":[223],"on":[224],"data":[226],"presented.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}