{"id":"https://openalex.org/W2052437191","doi":"https://doi.org/10.1109/ultsym.2011.0402","title":"A fast ultrasound molecular imaging method and its 3D visualization in vivo","display_name":"A fast ultrasound molecular imaging method and its 3D visualization in vivo","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2052437191","doi":"https://doi.org/10.1109/ultsym.2011.0402","mag":"2052437191"},"language":"en","primary_location":{"id":"doi:10.1109/ultsym.2011.0402","doi":"https://doi.org/10.1109/ultsym.2011.0402","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ultsym.2011.0402","pdf_url":null,"source":{"id":"https://openalex.org/S4393917990","display_name":"IEEE International Ultrasonics Symposium","issn_l":"1948-5719","issn":["1948-5719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Ultrasonics Symposium","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031090970","display_name":"Xiaowen Hu","orcid":"https://orcid.org/0000-0002-4295-0747","observed_orcids":["https://orcid.org/0000-0002-4295-0747"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowen Hu","raw_affiliation_strings":["[University of California, Davis, CA~, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of California, Davis, CA~, USA]","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082015021","display_name":"Lisa M. Mahakian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Mahakian","raw_affiliation_strings":["[University of California, Davis, CA~, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of California, Davis, CA~, USA]","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017274918","display_name":"Charles F. Caskey","orcid":"https://orcid.org/0000-0003-4545-4842","observed_orcids":["https://orcid.org/0000-0003-4545-4842"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Caskey","raw_affiliation_strings":["[University of California, Davis, CA~, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of California, Davis, CA~, USA]","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065379732","display_name":"Julie R. Beegle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Beegle","raw_affiliation_strings":["[University of California, Davis, CA~, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of California, Davis, CA~, USA]","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041838058","display_name":"Dustin E. Kruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dustin Kruse","raw_affiliation_strings":["[University of California, Davis, CA~, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of California, Davis, CA~, USA]","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070672238","display_name":"Joshua J. Rychak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162680","display_name":"Targeson (United States)","ror":"https://ror.org/0570hc946","country_code":"US","type":"company","lineage":["https://openalex.org/I4210162680"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Rychak","raw_affiliation_strings":["University of California Davis, CA, USA","Targeson, Inc., San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Targeson, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210162680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087646802","display_name":"Patrick L. Sutcliffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162680","display_name":"Targeson (United States)","ror":"https://ror.org/0570hc946","country_code":"US","type":"company","lineage":["https://openalex.org/I4210162680"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Sutcliffe","raw_affiliation_strings":["Targeson, Inc., San Diego, CA, USA","[University of California, Davis, CA~, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Targeson, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210162680"]},{"raw_affiliation_string":"[University of California, Davis, CA~, USA]","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013037422","display_name":"Katherine W. Ferrara","orcid":"https://orcid.org/0000-0002-4976-9107","observed_orcids":["https://orcid.org/0000-0002-4976-9107"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Ferrara","raw_affiliation_strings":["[University of California, Davis, CA~, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of California, Davis, CA~, USA]","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1739668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":null,"first_page":"1618","last_page":"1621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasound-molecular-imaging","display_name":"ultrasound molecular imaging","score":0.9480000138282776},{"id":"https://openalex.org/keywords/targeted-microbubbles","display_name":"targeted microbubbles","score":0.9929999709129333},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.6129999756813049},{"id":"https://openalex.org/keywords/tumor-vascular-targeting","display_name":"tumor vascular targeting","score":0.4020000100135803},{"id":"https://openalex.org/keywords/3d-ultrasound","display_name":"3D ultrasound","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.7152765989303589},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.5402519106864929},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.5070452690124512},{"id":"https://openalex.org/C183816354","wikidata":"https://www.wikidata.org/wiki/Q665617","display_name":"Infinite impulse response","level":4,"score":0.4909534752368927},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.4854469895362854},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47661033272743225},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4720768928527832},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4602813124656677},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.429061621427536},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.4234151840209961},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.42324894666671753},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4095332622528076},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3369729518890381},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3119015097618103},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.25091978907585144},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.2396927773952484},{"id":"https://openalex.org/C36390408","wikidata":"https://www.wikidata.org/wiki/Q1163067","display_name":"Digital filter","level":3,"score":0.1924515962600708},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.1757166087627411},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14142945408821106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12427690625190735},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ultsym.2011.0402","doi":"https://doi.org/10.1109/ultsym.2011.0402","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ultsym.2011.0402","pdf_url":null,"source":{"id":"https://openalex.org/S4393917990","display_name":"IEEE International Ultrasonics Symposium","issn_l":"1948-5719","issn":["1948-5719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Ultrasonics Symposium","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1983218679","https://openalex.org/W1990938811","https://openalex.org/W2059507143","https://openalex.org/W2093804120","https://openalex.org/W2116551025","https://openalex.org/W2146391103","https://openalex.org/W2146869864","https://openalex.org/W2156270047","https://openalex.org/W2161549257"],"related_works":["https://openalex.org/W7067796940","https://openalex.org/W44825215","https://openalex.org/W2059507143","https://openalex.org/W2107558659","https://openalex.org/W2019156009","https://openalex.org/W2123736266","https://openalex.org/W2058352372","https://openalex.org/W7114797222","https://openalex.org/W4308099571","https://openalex.org/W1995112465"],"abstract_inverted_index":{"Using":[0],"targeted":[1,199],"microbubbles":[2],"(MBs),":[3],"ultrasound":[4],"molecular":[5],"imaging":[6,143],"can":[7,47],"be":[8,48],"used":[9],"to":[10,20,99,105,163],"selectively":[11],"and":[12,64,91],"specifically":[13],"visualize":[14],"upregulated":[15],"vascular":[16],"receptors.":[17],"In":[18],"order":[19],"acquire":[21],"bound":[22,110,206],"MB":[23],"echoes,":[24],"a":[25,80,92,127,146],"delay":[26],"of":[27,36,58,84,109,114,119,122,205,229],"~7-15":[28],"minutes":[29],"is":[30],"commonly":[31],"required":[32],"for":[33,75],"the":[34,51,56,73,100,107,120,140,159,164,177,187,191,203,209,211,227],"clearance":[35],"freely":[37],"circulating":[38],"MBs.":[39,116,207,231],"Here,":[40],"we":[41],"test":[42],"whether":[43],"echoes":[44,172],"from":[45,50,112,173,215],"MBs":[46,111,125,175,219],"distinguished":[49],"surrounding":[52,178],"tissue,":[53],"based":[54],"on":[55],"transmission":[57],"pulses":[59],"at":[60,66,169],"low":[61],"(1.5":[62],"MHz)":[63,69],"reception":[65],"high":[67],"(5.5":[68],"frequencies":[70],"(TLRH),":[71],"without":[72],"requirement":[74],"destructive":[76],"pulses.":[77],"Pulses":[78],"with":[79],"peak":[81],"negative":[82],"pressure":[83],"230":[85],"kPa":[86],"were":[87,132,181],"transmitted":[88],"(10":[89],"fps)":[90],"7thorder":[93,160],"IIR":[94,161],"pulse-to-pulse":[95],"filter":[96,162],"was":[97,193,220],"applied":[98],"TLRH":[101,165],"radiofrequency":[102],"(RF)":[103],"data":[104,167],"distinguish":[106],"signature":[108],"that":[113,139,225],"flowing":[115,174],"3D":[117],"images":[118,200],"accumulation":[121],"intravenously-administrated":[123],"integrin-targeted":[124],"in":[126,135,176],"Met-1":[128],"mouse":[129],"tumor":[130,192],"model":[131],"acquired.":[133],"An":[134],"vitro":[136],"study":[137],"demonstrated":[138],"T2R15":[141],"contrast":[142,152],"technique":[144],"has":[145],"~2-fold":[147],"resolution":[148],"improvement":[149],"over":[150],"2MHz":[151],"pulse":[153],"sequencing":[154],"(CPS)":[155],"imaging.":[156],"By":[157],"applying":[158],"RF":[166],"acquired":[168],"2":[170],"minutes,":[171],"tissue":[179],"region":[180],"suppressed":[182,194],"by":[183,195],"26\u00b12":[184],"dB,":[185],"while":[186],"signal":[188,212],"intensity":[189,213],"within":[190],"4\u00b11":[196],"dB.":[197],"The":[198],"correctly":[201],"represented":[202],"distribution":[204],"After":[208],"filter,":[210],"resulting":[214],"cyclic":[216],"RGD":[217],"bearing":[218],"25\u00b12":[221],"dB":[222],"higher":[223],"than":[224],"after":[226],"injection":[228],"non-targeted":[230]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
