{"id":"https://openalex.org/W2052426317","doi":"https://doi.org/10.1097/00003246-200112000-00002","title":"Effects of burn with and without Escherichia coli infection in rats on intestinal vs. splenic T-cell responses","display_name":"Effects of burn with and without Escherichia coli infection in rats on intestinal vs. splenic T-cell responses","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2052426317","doi":"https://doi.org/10.1097/00003246-200112000-00002","mag":"2052426317","pmid":"https://pubmed.ncbi.nlm.nih.gov/11801815"},"language":"en","primary_location":{"id":"doi:10.1097/00003246-200112000-00002","doi":"https://doi.org/10.1097/00003246-200112000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00003246-200112000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054936080","display_name":"Thyyar M. Ravindranath","orcid":"https://orcid.org/0000-0002-0712-2065","observed_orcids":["https://orcid.org/0000-0002-0712-2065"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thyyar Ravindranath","raw_affiliation_strings":["Department of Pediatrics, Ronald McDonald Children's' Hospital, Loyola University Medical Center, Maywood, IL 60153, USA","Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ronald McDonald Children's' Hospital, Loyola University Medical Center, Maywood, IL 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052285767","display_name":"Walid M. Al\u2010Ghoul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walid Al-Ghoul","raw_affiliation_strings":["the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078338886","display_name":"Shahla Namak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahla Namak","raw_affiliation_strings":["the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029386613","display_name":"Nadeem Fazal","orcid":"https://orcid.org/0000-0002-9826-4391","observed_orcids":["https://orcid.org/0000-0002-9826-4391"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadeem Fazal","raw_affiliation_strings":["the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026140526","display_name":"Ram\u00f3n Durazo-Arviz\u00fa","orcid":"https://orcid.org/0000-0001-6563-7107","observed_orcids":["https://orcid.org/0000-0001-6563-7107"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramon Durazo-Arvizu","raw_affiliation_strings":["the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","institution_ids":[]},{"raw_affiliation_string":"Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084027124","display_name":"Mashkoor A. Choudhry","orcid":"https://orcid.org/0000-0002-1152-7145","observed_orcids":["https://orcid.org/0000-0002-1152-7145"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mashkoor Choudhry","raw_affiliation_strings":["the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. E-mail: [email\u00a0protected]","From the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","Our studies provide evidence that the changes in T-cell functions in both Peyer\u2019s patch and splenic T cells with burn alone or burn plus infection (3-day postburn) are accompanied by alterations in T-cell Ca2+ signaling, which is a major determinant of the intracellular mechanism for T-cell activation and, thus, of the regulation of T-cell interleukin-2 production and proliferative functions","Supported, in part, by grants GM 53235 and GM 56865 from the National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Surgery (WA-G, SN, NF, MC, MMS), Physiology (MMS), Pediatrics (TR), and Preventive Medicine & Epidemiology (RD-A), the Burn & Shock Trauma Institute (WA-G, NF, MC, MMS), and Ronald McDonald Children\u2019s\u2019 Hospital (TR), Loyola University Medical Center, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Address requests for reprints to: Mohammed M. Sayeed, PhD, Department of Surgery, Burn & Shock Trauma Institute, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153. 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