{"id":"https://openalex.org/W2052425671","doi":"https://doi.org/10.1160/th06-04-0224","title":"A novel mechanism of transcriptional repression of p27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells","display_name":"A novel mechanism of transcriptional repression of p27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2052425671","doi":"https://doi.org/10.1160/th06-04-0224","mag":"2052425671","pmid":"https://pubmed.ncbi.nlm.nih.gov/16953280"},"language":"en","primary_location":{"id":"doi:10.1160/th06-04-0224","doi":"https://doi.org/10.1160/th06-04-0224","is_oa":false,"landing_page_url":"https://doi.org/10.1160/th06-04-0224","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091707594","display_name":"Matthew C. Havrda","orcid":"https://orcid.org/0000-0002-4411-382X","observed_orcids":["https://orcid.org/0000-0002-4411-382X"]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Havrda","raw_affiliation_strings":["Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074, USA","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014152060","display_name":"Michael Joseph Johnson","orcid":"https://orcid.org/0009-0006-2959-0122","observed_orcids":["https://orcid.org/0009-0006-2959-0122"]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Johnson","raw_affiliation_strings":["Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091494402","display_name":"Christine F. O\u2019Neill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine O\u2019Neill","raw_affiliation_strings":["Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA","institution_ids":["https://openalex.org/I4210146345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001736006","display_name":"Lucy Liaw","orcid":"https://orcid.org/0000-0003-3341-0156","observed_orcids":["https://orcid.org/0000-0003-3341-0156"]},"institutions":[{"id":"https://openalex.org/I4210146345","display_name":"Maine Medical Center Research Institute","ror":"https://ror.org/03d1wq758","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102705","https://openalex.org/I4210123774","https://openalex.org/I4210146345"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lucy Liaw","raw_affiliation_strings":["Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA","institution_ids":["https://openalex.org/I4210146345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001736006"],"corresponding_institution_ids":["https://openalex.org/I4210146345"],"apc_list":null,"apc_paid":null,"fwci":1.3498,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.77823597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"09","first_page":"361","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.8939999938011169},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/g1-s-checkpoint","display_name":"G1/S checkpoint","score":0.9210000038146973},{"id":"https://openalex.org/keywords/smooth-muscle-cell-proliferation","display_name":"smooth muscle cell proliferation","score":0.746999979019165},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.8709999918937683},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/restenosis","display_name":"restenosis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.8080000281333923},{"id":"https://openalex.org/keywords/notch4","display_name":"Notch4","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.8229858875274658},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.802497148513794},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7247399091720581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6130603551864624},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5853729248046875},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.55540931224823},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5508008599281311},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.5464157462120056},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5017821788787842},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4880460500717163},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47216007113456726},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28685706853866577},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2509680390357971},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15666693449020386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13801074028015137},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.13450604677200317},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1160/th06-04-0224","doi":"https://doi.org/10.1160/th06-04-0224","is_oa":false,"landing_page_url":"https://doi.org/10.1160/th06-04-0224","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:16953280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16953280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3587210076","display_name":null,"funder_award_id":"R01HL070865 and P20RR15555","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5529095544","display_name":"COBRE in Stem Cell Biology and Regenerative Medicine","funder_award_id":"5p20rr018789-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G696278999","display_name":null,"funder_award_id":"P20-RR18789","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W61556301","https://openalex.org/W1596659824","https://openalex.org/W1956254370","https://openalex.org/W1963058400","https://openalex.org/W1965927288","https://openalex.org/W1968068296","https://openalex.org/W1969091160","https://openalex.org/W1971397534","https://openalex.org/W1983322974","https://openalex.org/W1991122929","https://openalex.org/W1993363599","https://openalex.org/W2005744028","https://openalex.org/W2006556286","https://openalex.org/W2019688531","https://openalex.org/W2025010136","https://openalex.org/W2039260492","https://openalex.org/W2043180327","https://openalex.org/W2050635677","https://openalex.org/W2056916102","https://openalex.org/W2058734213","https://openalex.org/W2071196711","https://openalex.org/W2076890216","https://openalex.org/W2078125708","https://openalex.org/W2082533282","https://openalex.org/W2083800064","https://openalex.org/W2091403769","https://openalex.org/W2091643606","https://openalex.org/W2092034939","https://openalex.org/W2097466570","https://openalex.org/W2098817749","https://openalex.org/W2099673075","https://openalex.org/W2100979164","https://openalex.org/W2109380828","https://openalex.org/W2118702666","https://openalex.org/W2124892165","https://openalex.org/W2126659307","https://openalex.org/W2144458244","https://openalex.org/W2146220316","https://openalex.org/W2147135997","https://openalex.org/W2147435977","https://openalex.org/W2152637226","https://openalex.org/W2153360321","https://openalex.org/W2155690700","https://openalex.org/W2166444258","https://openalex.org/W2172060727"],"related_works":["https://openalex.org/W1543402492","https://openalex.org/W4320492283","https://openalex.org/W4214695225","https://openalex.org/W3197607994","https://openalex.org/W2064085750","https://openalex.org/W2783284266","https://openalex.org/W4380992933","https://openalex.org/W4309090929","https://openalex.org/W3020059968","https://openalex.org/W2171209136"],"abstract_inverted_index":{"Vascular":[0],"smooth":[1,25,63],"muscle":[2,26,64],"cell":[3,59,105,219],"(VSMC)":[4],"proliferation":[5],"occurs":[6],"in":[7,24,62,80,93,169,233],"vascular":[8,29,237],"obstructive":[9],"events":[10],"such":[11],"as":[12],"atherosclerosis":[13],"and":[14,48,56,66,101,117,143,212,239],"restenosis.":[15],"We":[16,223],"previously":[17],"showed":[18],"that":[19,120,147,160,214,225],"Notch":[20,40,161,187,215],"receptors":[21],"are":[22],"induced":[23,50],"cells":[27],"during":[28,236],"remodeling.":[30],"Our":[31,157],"goal":[32],"was":[33,75,111],"to":[34,42,68,113,128,164,230],"determine":[35],"the":[36,51,83,98,104,125,135,174,186,193,197],"mechanisms":[37],"employed":[38],"by":[39,171,184],"signaling":[41,162],"regulate":[43],"proliferation.":[44],"Activation":[45],"of":[46,70,82,90,97,173,196,210],"Notch1":[47],"Notch4":[49],"VSMC-selective":[52],"target":[53,209],"genes":[54],"HRT1":[55],"HRT2,":[57,189,211],"promoted":[58],"cycle":[60,220],"transit":[61],"cells,":[65],"led":[67],"loss":[69],"density-dependent":[71],"growth":[72],"inhibition.":[73],"This":[74],"associated":[76],"with":[77,124,192],"a":[78,94,153,166,181,206],"reduction":[79],"levels":[81],"cyclin-dependent":[84],"kinase":[85],"inhibitor":[86],"(cdk)":[87],"p27(kip1).":[88],"Over-expression":[89],"p27(kip1)":[91,126,140,198],"resulted":[92],"dose-dependent":[95],"rescue":[96],"Notch-induced":[99],"phenotype":[100,168],"exit":[102],"from":[103],"cycle.":[106],"In":[107,177],"addition,":[108,178],"HRT2":[109,121],"expression":[110],"sufficient":[112],"promote":[114,165],"S-phase":[115],"entry,":[116],"we":[118,179],"demonstrate":[119],"interacts":[122,190],"directly":[123,191,217],"promoter":[127,141],"repress":[129],"transcription.":[130],"Transcriptional":[131],"repression":[132,148],"occurred":[133],"within":[134],"approximately":[136],"774":[137],"bp":[138],"minimal":[139],"region":[142],"mutational":[144],"analysis":[145],"demonstrated":[146],"is":[149,228],"largely":[150],"dependent":[151],"on":[152],"conserved":[154],"class-C":[155,194],"domain.":[156],"data":[158],"show":[159,213],"acts":[163],"proliferative":[167],"VSMC":[170,234],"modulation":[172],"G1/S-phase":[175],"checkpoint.":[176],"define":[180],"novel":[182,207],"mechanism":[183,227],"which":[185],"effector,":[188],"domain":[195],"promoter,":[199],"repressing":[200],"its":[201],"expression.":[202],"These":[203],"studies":[204],"identify":[205],"transcriptional":[208],"effectors":[216],"control":[218],"regulatory":[221],"components.":[222],"suggest":[224],"this":[226],"relevant":[229],"hyperproliferative":[231],"states":[232],"seen":[235],"remodeling":[238],"repair.":[240]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2025-10-10T00:00:00"}
