{"id":"https://openalex.org/W2052397467","doi":"https://doi.org/10.1371/journal.ppat.1002100","title":"HIV-1 Efficient Entry in Inner Foreskin Is Mediated by Elevated CCL5/RANTES that Recruits T Cells and Fuels Conjugate Formation with Langerhans Cells","display_name":"HIV-1 Efficient Entry in Inner Foreskin Is Mediated by Elevated CCL5/RANTES that Recruits T Cells and Fuels Conjugate Formation with Langerhans Cells","publication_year":2011,"publication_date":"2011-06-30","ids":{"openalex":"https://openalex.org/W2052397467","doi":"https://doi.org/10.1371/journal.ppat.1002100","mag":"2052397467","pmid":"https://pubmed.ncbi.nlm.nih.gov/21738469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3128116"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1002100","doi":"https://doi.org/10.1371/journal.ppat.1002100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1002100","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002100&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002100&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050828277","display_name":"Zhicheng Zhou","orcid":"https://orcid.org/0000-0001-9137-7951","observed_orcids":["https://orcid.org/0000-0001-9137-7951"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zhicheng Zhou","raw_affiliation_strings":["Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France","INSERM, U1016, Paris, France","Universit\u00e9 Paris Descartes, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"INSERM, U1016, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086718204","display_name":"Nicolas Barry Delongchamps","orcid":"https://orcid.org/0000-0001-5827-9567","observed_orcids":["https://orcid.org/0000-0001-5827-9567"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Barry de Longchamps","raw_affiliation_strings":["Electron Microscopy Platform, Cochin Institute, CNRS (UMR 8104), Paris, France","Universit\u00e9 Paris Descartes, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electron Microscopy Platform, Cochin Institute, CNRS (UMR 8104), Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027231771","display_name":"Alain Schmitt","orcid":"https://orcid.org/0000-0002-8011-2277","observed_orcids":["https://orcid.org/0000-0002-8011-2277","https://orcid.org/0000-0002-3565-8692"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Schmitt","raw_affiliation_strings":["Electron Microscopy Platform, Cochin Institute, CNRS (UMR 8104), Paris, France","INSERM, U1016, Paris, France","Universit\u00e9 Paris Descartes, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electron Microscopy Platform, Cochin Institute, CNRS (UMR 8104), Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"INSERM, U1016, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050255590","display_name":"Marc Zerbib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Zerbib","raw_affiliation_strings":["Universit\u00e9 Paris Descartes, Paris, France","Urology Service, GH Cochin-St Vincent de Paul, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Urology Service, GH Cochin-St Vincent de Paul, Paris, France","institution_ids":["https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111581795","display_name":"Marie\u2010C\u00e9cile Vacher\u2010Lavenu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-C\u00e9cile Vacher-Lavenu","raw_affiliation_strings":["Department of Pathology, GH Cochin-St Vincent de Paul, Paris, France","Universit\u00e9 Paris Descartes, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, GH Cochin-St Vincent de Paul, Paris, France","institution_ids":["https://openalex.org/I4210092774"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030948367","display_name":"Morgane Bomsel","orcid":"https://orcid.org/0000-0002-9577-7474","observed_orcids":["https://orcid.org/0000-0002-9577-7474"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Morgane Bomsel","raw_affiliation_strings":["INSERM, U1016, Paris, France","Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France","Universit\u00e9 Paris Descartes, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U1016, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010855767","display_name":"Yonatan Ganor","orcid":"https://orcid.org/0000-0003-4430-7744","observed_orcids":["https://orcid.org/0000-0003-4430-7744"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yonatan Ganor","raw_affiliation_strings":["INSERM, U1016, Paris, France","Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France","Universit\u00e9 Paris Descartes, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U1016, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Mucosal Entry of HIV-1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS (UMR 8104), Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes, Paris, France","institution_ids":["https://openalex.org/I4387156284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030948367"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210141964","https://openalex.org/I4387156284"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":3.0071,"has_fulltext":true,"cited_by_count":103,"citation_normalized_percentile":{"value":0.92062315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"7","issue":"6","first_page":"e1002100","last_page":"e1002100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-entry","display_name":"HIV-1 entry","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ccl5-rantes","display_name":"CCL5/RANTES","score":0.9779999852180481},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7590000033378601},{"id":"https://openalex.org/keywords/langerhans-cells","display_name":"Langerhans cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/t-cell-recruitment","display_name":"T cell recruitment","score":0.9639999866485596},{"id":"https://openalex.org/keywords/male-circumcision","display_name":"male circumcision","score":0.6439999938011169},{"id":"https://openalex.org/keywords/hiv-1-transmission","display_name":"HIV-1 transmission","score":0.7570000290870667},{"id":"https://openalex.org/keywords/chemokine-gradients","display_name":"chemokine gradients","score":0.5180000066757202},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2781140480","wikidata":"https://www.wikidata.org/wiki/Q673203","display_name":"Foreskin","level":3,"score":0.9805909395217896},{"id":"https://openalex.org/C116484652","wikidata":"https://www.wikidata.org/wiki/Q3492926","display_name":"CCL5","level":5,"score":0.6047301888465881},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.42624416947364807},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4122336506843567},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.38891398906707764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37343525886535645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36185747385025024},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35651451349258423},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3411791920661926},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3397057056427002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3333067297935486},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2817617654800415},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.24182772636413574},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.09048861265182495},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07463613152503967},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002944","descriptor_name":"Circumcision, Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D052816","descriptor_name":"Foreskin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D052816","descriptor_name":"Foreskin","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054418","descriptor_name":"Chemokine CCL20","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.ppat.1002100","doi":"https://doi.org/10.1371/journal.ppat.1002100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1002100","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002100&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmid:21738469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21738469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3128116","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3128116/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3a582dda664b4b6895530438b59c1d1d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3a582dda664b4b6895530438b59c1d1d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 7, Iss 6, p e1002100 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1002100","doi":"https://doi.org/10.1371/journal.ppat.1002100","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1002100","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002100&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307875","display_name":"Styrelsen f\u00f6r Internationellt Utvecklingssamarbete","ror":"https://ror.org/01fn7me06"},{"id":"https://openalex.org/F4320310985","display_name":"Sidaction","ror":"https://ror.org/04z6q9z55"},{"id":"https://openalex.org/F4320322292","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052397467.pdf","grobid_xml":"https://content.openalex.org/works/W2052397467.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1522057669","https://openalex.org/W1653335370","https://openalex.org/W1891279436","https://openalex.org/W1964463879","https://openalex.org/W1974616965","https://openalex.org/W1977408485","https://openalex.org/W1986132830","https://openalex.org/W2000698869","https://openalex.org/W2022280258","https://openalex.org/W2023923364","https://openalex.org/W2025346994","https://openalex.org/W2027344845","https://openalex.org/W2028100045","https://openalex.org/W2032337083","https://openalex.org/W2039062327","https://openalex.org/W2040026254","https://openalex.org/W2053601970","https://openalex.org/W2054564712","https://openalex.org/W2062561488","https://openalex.org/W2074620757","https://openalex.org/W2074673603","https://openalex.org/W2075847325","https://openalex.org/W2078489697","https://openalex.org/W2081116633","https://openalex.org/W2087166273","https://openalex.org/W2089381270","https://openalex.org/W2091514999","https://openalex.org/W2098615501","https://openalex.org/W2101072866","https://openalex.org/W2105694909","https://openalex.org/W2110673598","https://openalex.org/W2115373328","https://openalex.org/W2121750736","https://openalex.org/W2122215095","https://openalex.org/W2123626917","https://openalex.org/W2125121115","https://openalex.org/W2127766835","https://openalex.org/W2134326405","https://openalex.org/W2141635380","https://openalex.org/W2143071104","https://openalex.org/W2145359348","https://openalex.org/W2145718464","https://openalex.org/W2146428988","https://openalex.org/W2149317992","https://openalex.org/W2154463442","https://openalex.org/W2155881222","https://openalex.org/W2156643487","https://openalex.org/W2161024777","https://openalex.org/W2161358581","https://openalex.org/W2171453333","https://openalex.org/W6639627161"],"related_works":["https://openalex.org/W7096235967","https://openalex.org/W2000698869","https://openalex.org/W1966298371","https://openalex.org/W2041250745","https://openalex.org/W2980628047","https://openalex.org/W2945581457","https://openalex.org/W2032337083","https://openalex.org/W1891279436","https://openalex.org/W2141635380","https://openalex.org/W2123626917"],"abstract_inverted_index":{"Male":[0],"circumcision":[1],"reduces":[2],"acquisition":[3],"of":[4,30,33,110,142,170,209,215,230],"HIV-1":[5,13,24,82,216,225,248],"by":[6,68,98,153,182,218],"60%.":[7],"Hence,":[8],"the":[9,34,59,64,69,76,99,122,145,148,167,175,186,206,213,235],"foreskin":[10,39,61,81,84,100,237],"is":[11,151,239],"an":[12],"entry":[14,249],"portal":[15],"during":[16],"sexual":[17],"transmission.":[18],"We":[19],"recently":[20],"reported":[21],"that":[22,120,224,238],"efficient":[23,247],"transmission":[25],"occurs":[26],"following":[27],"1":[28,179],"h":[29],"polarized":[31],"exposure":[32],"inner,":[35],"but":[36,43],"not":[37,44],"outer,":[38],"to":[40,45,174],"HIV-1-infected":[41,127,160],"cells,":[42],"cell-free":[46],"virus.":[47,70],"At":[48],"this":[49,200,251],"early":[50],"time":[51,201],"point,":[52],"Langerhans":[53],"cells":[54,66,90,128,161,232],"(LCs)":[55],"and":[56,102,107,112,133],"T-cells":[57,111,143],"within":[58],"inner":[60,80,123,236],"epidermis":[62],"are":[63],"first":[65],"targeted":[67],"To":[71],"gain":[72],"in-depth":[73],"insight":[74],"into":[75,147],"molecular":[77],"mechanisms":[78],"governing":[79],"entry,":[83],"explants":[85],"were":[86,114],"inoculated":[87],"with":[88,126,196,241],"HIV-1-infeceted":[89],"for":[91],"4":[92,192],"h.":[93],"The":[94],"chemokine/cytokine":[95],"milieu":[96],"secreted":[97],"tissue,":[101],"resulting":[103],"modifications":[104],"in":[105,121,166,194,234],"density":[106],"spatial":[108,168],"distribution":[109,169],"LCs,":[113],"then":[115],"investigated.":[116],"Our":[117],"studies":[118],"show":[119],"foreskin,":[124],"inoculation":[125],"induces":[129,226],"increased":[130],"CCL5/RANTES":[131,139,156],"(1.63-fold)":[132],"decreased":[134],"CCL20/MIP-3-alpha":[135,198],"(0.62-fold)":[136],"secretion.":[137],"Elevated":[138],"mediates":[140],"recruitment":[141,204],"from":[144],"dermis":[146],"epidermis,":[149],"which":[150,245],"blocked":[152],"a":[154,163,227],"neutralizing":[155],"Ab.":[157],"In":[158],"parallel,":[159],"mediate":[162],"bi-phasic":[164],"modification":[165],"epidermal":[171],"LCs:":[172],"attraction":[173],"apical":[176],"surface":[177],"at":[178,191,199,250],"h,":[180,193],"followed":[181],"migration":[183],"back":[184],"towards":[185],"basement":[187],"membrane":[188],"later":[189],"on":[190],"correlation":[195],"reduced":[197],"point.":[202],"T-cell":[203],"fuels":[205],"continuous":[207],"formation":[208],"LC-T-cell":[210],"conjugates,":[211],"permitting":[212],"transfer":[214],"captured":[217],"LCs.":[219],"Together,":[220],"these":[221],"results":[222],"reveal":[223],"dynamic":[228],"process":[229],"immune":[231],"relocation":[233],"associated":[240],"specific":[242],"chemokines":[243],"secretion,":[244],"favors":[246],"site.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
