{"id":"https://openalex.org/W2052391290","doi":"https://doi.org/10.1089/aid.2009.0022","title":"Short Communication: Association of HLA-A*1101 with Resistance and B*4006 with Susceptibility to HIV and HIV-TB: An in Silico Analysis of Promiscuous T Cell Epitopes","display_name":"Short Communication: Association of HLA-A*1101 with Resistance and B*4006 with Susceptibility to HIV and HIV-TB: An in Silico Analysis of Promiscuous T Cell Epitopes","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2052391290","doi":"https://doi.org/10.1089/aid.2009.0022","mag":"2052391290","pmid":"https://pubmed.ncbi.nlm.nih.gov/19803716"},"language":"en","primary_location":{"id":"doi:10.1089/aid.2009.0022","doi":"https://doi.org/10.1089/aid.2009.0022","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.2009.0022","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066794848","display_name":"Sampathkumar Raghavan","orcid":"https://orcid.org/0000-0003-3500-9083","observed_orcids":["https://orcid.org/0000-0003-3500-9083"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. Raghavan","raw_affiliation_strings":["Department of Immunology, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai-600 031, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai-600 031, India","institution_ids":["https://openalex.org/I37048141"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Selvaraj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"P. Selvaraj","raw_affiliation_strings":["Department of Immunology, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai-600 031, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai-600 031, India","institution_ids":["https://openalex.org/I37048141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076624513","display_name":"Soumya Swaminathan","orcid":"https://orcid.org/0009-0004-2233-7250","observed_orcids":["https://orcid.org/0009-0004-2233-7250"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. Swaminathan","raw_affiliation_strings":["Department of Clinical Research, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai-600 031, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai-600 031, India","institution_ids":["https://openalex.org/I37048141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021873932","display_name":"Gopalan Narendran","orcid":"https://orcid.org/0000-0002-8049-7541","observed_orcids":["https://orcid.org/0000-0002-8049-7541"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G. Narendran","raw_affiliation_strings":["Department of Clinical Research, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai-600 031, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai-600 031, India","institution_ids":["https://openalex.org/I37048141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I37048141"],"apc_list":null,"apc_paid":null,"fwci":0.4382,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.61679174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"25","issue":"10","first_page":"1023","last_page":"1028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.09229999780654907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-a-11-01","display_name":"HLA-A*11:01","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hla-a11","display_name":"HLA-A11","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hla-b40","display_name":"HLA-B40","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hla-dr2","display_name":"HLA-DR2","score":0.859000027179718},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hiv-susceptibility","display_name":"HIV susceptibility","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hiv-tb-co-infection","display_name":"HIV/TB coinfection","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tuberculosis-susceptibility","display_name":"tuberculosis susceptibility","score":0.7720000147819519},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hiv-1-subtype-c","display_name":"HIV-1 subtype C","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.6990854740142822},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6384750008583069},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6237431168556213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5619917511940002},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5485438108444214},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5377035737037659},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5273628830909729},{"id":"https://openalex.org/C2910492473","wikidata":"https://www.wikidata.org/wiki/Q18026920","display_name":"HLA-B Antigens","level":4,"score":0.4564213752746582},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.41071081161499023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30583399534225464},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.20720124244689941},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18637865781784058},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08187034726142883},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059870","descriptor_name":"HLA-A11 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/aid.2009.0022","doi":"https://doi.org/10.1089/aid.2009.0022","is_oa":false,"landing_page_url":"https://doi.org/10.1089/aid.2009.0022","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},{"id":"pmid:19803716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19803716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS research and human retroviruses","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.nirt.res.in:975","doi":null,"is_oa":false,"landing_page_url":"https://eprints.nirt.res.in//975/1/200958.pdf","pdf_url":"https://eprints.nirt.res.in//975/1/200958.pdf","source":{"id":"https://openalex.org/S4377196491","display_name":"NIRT Institutional Scholarship Repository (National Institute of Research in Tuberculosis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140595","host_organization_name":"National Institute of Research in Tuberculosis","host_organization_lineage":["https://openalex.org/I4210140595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1933948779","https://openalex.org/W1957434785","https://openalex.org/W1983967166","https://openalex.org/W1994193221","https://openalex.org/W2004075583","https://openalex.org/W2011033037","https://openalex.org/W2041643036","https://openalex.org/W2042434530","https://openalex.org/W2053014294","https://openalex.org/W2058894986","https://openalex.org/W2076225720","https://openalex.org/W2088400322","https://openalex.org/W2099182602","https://openalex.org/W2115673224","https://openalex.org/W2132609988","https://openalex.org/W2134182833","https://openalex.org/W2135709828","https://openalex.org/W2142636897","https://openalex.org/W2151214905","https://openalex.org/W2170430128","https://openalex.org/W3043115433"],"related_works":["https://openalex.org/W7043001205","https://openalex.org/W1994193221","https://openalex.org/W6991443409","https://openalex.org/W1983967166","https://openalex.org/W7064129558","https://openalex.org/W3131878140","https://openalex.org/W2591627884","https://openalex.org/W2028885572","https://openalex.org/W3099136865","https://openalex.org/W2768362911"],"abstract_inverted_index":{"We":[0],"have":[1],"shown":[2],"the":[3,20,33,38,185,213],"association":[4],"of":[5,27,47,81,132,137,143,153,166,187,215,217,221],"HLA-A*11":[6,28],"with":[7,13,180,197],"resistance":[8],"and":[9,11,17,29,64,111,140,157,184,201],"HLA-B*40":[10],"-DR2":[12],"susceptibility":[14,198],"to":[15,31,75,125,163,199],"HIV":[16,53,87,183,190,200,205],"HIV-TB.":[18],"In":[19],"present":[21,208],"study,":[22],"we":[23],"performed":[24],"high-resolution":[25],"subtyping":[26],"-B*40":[30],"identify":[32],"subtype":[34,145,223],"level":[35],"association,":[36],"using":[37],"polymerase":[39],"chain":[40],"reaction-based":[41],"sequence-specific":[42],"oligonucleotide":[43],"probe":[44],"method.":[45],"Underrepresentation":[46],"HLA-A*1101":[48,176],"was":[49],"observed":[50,84],"in":[51,85,129,161,189,204],"overall":[52,86],"[p(c)":[54,66],"=":[55,67,89,92,101,104,114,117],"0.012,":[56],"OR":[57,69,94,106,119],"0.42":[58],"(95%":[59,71,96,108,121],"confidence":[60],"interval":[61],"(CI)":[62],"0.24-0.72)]":[63],"HIV(+)TB(+)":[65,112],"0.001,":[68],"0.18":[70],"CI":[72,97,109,122],"0.06-0.46)]":[73],"compared":[74,124],"healthy":[76,126],"controls.":[77,127],"Significantly":[78],"higher":[79,151],"frequencies":[80],"HLA-B*4006":[82,193],"were":[83],"[p":[88,100,113],"0.0001,":[90],"p(c)":[91,103,116],"0.004,":[93],"2.71":[95],"1.58-4.75)],":[98],"HIV(+)TB(-)":[99],"0.0003,":[102],"0.008,":[105],"2.82":[107],"1.56-5.17)],":[110],"0.003,":[115],"0.086,":[118],"2.56":[120],"1.33-4.95)]":[123],"An":[128],"silico":[130],"analysis":[131],"potential":[133],"T":[134,218],"cell":[135,219],"epitopes":[136,160,220],"consensus":[138],"Gag":[139],"Pol":[141],"sequences":[142],"HIV-1":[144,222],"C":[146,224],"Indian":[147],"strains":[148],"revealed":[149],"relatively":[150],"number":[152],"promiscuous":[154,167],"HLA-B40,":[155],"HLA-DRB1*1501,":[156],"-DRB1*1502":[158],"(HLA-DR2)-restricted":[159],"contrast":[162],"limited":[164],"numbers":[165],"binders":[168],"restricted":[169,225],"by":[170,226],"HLA-A*1101.":[171],"The":[172,207],"results":[173],"suggest":[174],"that":[175,212],"may":[177,194],"be":[178,195],"associated":[179,196],"protection":[181],"against":[182],"development":[186,203],"TB":[188,202],"patients":[191],"while":[192],"patients.":[206],"study":[209],"also":[210],"suggests":[211],"extent":[214],"promiscuity":[216],"HLA":[227],"alleles":[228],"exerting":[229],"opposing":[230],"effects":[231],"might":[232],"differ.":[233]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}