{"id":"https://openalex.org/W205237139","doi":"https://doi.org/10.1007/978-3-319-02970-2_12","title":"NMR and Computational Methods in the Structural and Dynamic Characterization of Ligand-Receptor Interactions","display_name":"NMR and Computational Methods in the Structural and Dynamic Characterization of Ligand-Receptor Interactions","publication_year":2013,"publication_date":"2013-12-16","ids":{"openalex":"https://openalex.org/W205237139","doi":"https://doi.org/10.1007/978-3-319-02970-2_12","mag":"205237139","pmid":"https://pubmed.ncbi.nlm.nih.gov/24446366"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-02970-2_12","doi":"https://doi.org/10.1007/978-3-319-02970-2_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-02970-2_12","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W626438322","display_name":"Protein Conformational Dynamics"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089347292","display_name":"Michela Ghitti","orcid":"https://orcid.org/0000-0003-4059-0095","observed_orcids":["https://orcid.org/0000-0003-4059-0095"]},"institutions":[{"id":"https://openalex.org/I4210091790","display_name":"Dulbecco Telethon Institute","ror":"https://ror.org/00f7kfd14","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210091790","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Ghitti","raw_affiliation_strings":["Dulbecco Telethon Institute c/o Biomolecular NMR Laboratory S. Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dulbecco Telethon Institute c/o Biomolecular NMR Laboratory S. Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy","institution_ids":["https://openalex.org/I4210091790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002901056","display_name":"Giovanna Musco","orcid":"https://orcid.org/0000-0002-0469-2994","observed_orcids":["https://orcid.org/0000-0002-0469-2994"]},"institutions":[{"id":"https://openalex.org/I4210091790","display_name":"Dulbecco Telethon Institute","ror":"https://ror.org/00f7kfd14","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210091790","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giovanna Musco","raw_affiliation_strings":["Dulbecco Telethon Institute c/o Biomolecular NMR Laboratory S. Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dulbecco Telethon Institute c/o Biomolecular NMR Laboratory S. Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy","institution_ids":["https://openalex.org/I4210091790"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049162857","display_name":"Andrea Spitaleri","orcid":"https://orcid.org/0000-0003-3012-3557","observed_orcids":["https://orcid.org/0000-0003-3012-3557"]},"institutions":[{"id":"https://openalex.org/I4210091790","display_name":"Dulbecco Telethon Institute","ror":"https://ror.org/00f7kfd14","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210091790","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Spitaleri","raw_affiliation_strings":["Dulbecco Telethon Institute c/o Biomolecular NMR Laboratory S. Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dulbecco Telethon Institute c/o Biomolecular NMR Laboratory S. Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy","institution_ids":["https://openalex.org/I4210091790"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002901056"],"corresponding_institution_ids":["https://openalex.org/I4210091790"],"apc_list":null,"apc_paid":null,"fwci":2.9307,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.89568345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"805","issue":null,"first_page":"271","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.4616999924182892,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.4616999924182892,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.3237000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.13169999420642853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligand-receptor-interactions","display_name":"ligand-receptor interactions","score":0.9990000128746033},{"id":"https://openalex.org/keywords/molecular-recognition","display_name":"molecular recognition","score":0.9440000057220459},{"id":"https://openalex.org/keywords/conformational-dynamics","display_name":"conformational dynamics","score":0.7639999985694885},{"id":"https://openalex.org/keywords/lock-and-key-model","display_name":"lock-and-key model","score":0.7559999823570251},{"id":"https://openalex.org/keywords/nmr-spectroscopy","display_name":"NMR spectroscopy","score":0.7429999709129333},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.968999981880188},{"id":"https://openalex.org/keywords/conformational-analysis","display_name":"conformational analysis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.8370000123977661},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5869224071502686},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5411549806594849},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5369448661804199},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.519307553768158},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4948565363883972},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4712579548358917},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.44121965765953064},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4337500333786011},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4153721332550049},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.34523141384124756},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.344079852104187},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.24301224946975708},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24294859170913696},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.22170084714889526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21382814645767212},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.16173315048217773},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1521875560283661},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14501705765724182},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-319-02970-2_12","doi":"https://doi.org/10.1007/978-3-319-02970-2_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-02970-2_12","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:24446366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24446366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W20452789","https://openalex.org/W60468736","https://openalex.org/W78154441","https://openalex.org/W1580849631","https://openalex.org/W1646794664","https://openalex.org/W1874531505","https://openalex.org/W1966496513","https://openalex.org/W1969875513","https://openalex.org/W1972091733","https://openalex.org/W1973191530","https://openalex.org/W1974879154","https://openalex.org/W1975416940","https://openalex.org/W1983166043","https://openalex.org/W1986240377","https://openalex.org/W1986426155","https://openalex.org/W1987048011","https://openalex.org/W1990627326","https://openalex.org/W1995850373","https://openalex.org/W1996765646","https://openalex.org/W1997477098","https://openalex.org/W1998412941","https://openalex.org/W1999202878","https://openalex.org/W1999350919","https://openalex.org/W2000582473","https://openalex.org/W2001137370","https://openalex.org/W2003108724","https://openalex.org/W2003330684","https://openalex.org/W2003582562","https://openalex.org/W2003719817","https://openalex.org/W2005415465","https://openalex.org/W2007905703","https://openalex.org/W2009008563","https://openalex.org/W2012683574","https://openalex.org/W2012691080","https://openalex.org/W2013156594","https://openalex.org/W2013290808","https://openalex.org/W2013979082","https://openalex.org/W2014860988","https://openalex.org/W2018423148","https://openalex.org/W2018462893","https://openalex.org/W2020446183","https://openalex.org/W2024060531","https://openalex.org/W2025344323","https://openalex.org/W2026750808","https://openalex.org/W2027384625","https://openalex.org/W2029112828","https://openalex.org/W2030728145","https://openalex.org/W2031822741","https://openalex.org/W2035185380","https://openalex.org/W2036125311","https://openalex.org/W2036233893","https://openalex.org/W2037080421","https://openalex.org/W2037959733","https://openalex.org/W2038462292","https://openalex.org/W2038552179","https://openalex.org/W2039974355","https://openalex.org/W2040809566","https://openalex.org/W2041046009","https://openalex.org/W2042821667","https://openalex.org/W2043922597","https://openalex.org/W2049816773","https://openalex.org/W2050112352","https://openalex.org/W2052170989","https://openalex.org/W2055154361","https://openalex.org/W2059518315","https://openalex.org/W2059998193","https://openalex.org/W2062393760","https://openalex.org/W2064719064","https://openalex.org/W2066926304","https://openalex.org/W2067455153","https://openalex.org/W2067836657","https://openalex.org/W2068128475","https://openalex.org/W2068261875","https://openalex.org/W2069514727","https://openalex.org/W2069777230","https://openalex.org/W2072730567","https://openalex.org/W2073055599","https://openalex.org/W2075058728","https://openalex.org/W2075691196","https://openalex.org/W2088906583","https://openalex.org/W2089165578","https://openalex.org/W2090431249","https://openalex.org/W2092175995","https://openalex.org/W2093113767","https://openalex.org/W2093221728","https://openalex.org/W2093239283","https://openalex.org/W2094415940","https://openalex.org/W2097519353","https://openalex.org/W2099490136","https://openalex.org/W2099745384","https://openalex.org/W2100284567","https://openalex.org/W2105668062","https://openalex.org/W2107268230","https://openalex.org/W2110217865","https://openalex.org/W2112315506","https://openalex.org/W2113994268","https://openalex.org/W2114935976","https://openalex.org/W2118733486","https://openalex.org/W2125304058","https://openalex.org/W2125792789","https://openalex.org/W2126018286","https://openalex.org/W2126947308","https://openalex.org/W2127639267","https://openalex.org/W2131124255","https://openalex.org/W2132180320","https://openalex.org/W2132589721","https://openalex.org/W2133620840","https://openalex.org/W2134224798","https://openalex.org/W2134528197","https://openalex.org/W2135717332","https://openalex.org/W2136472469","https://openalex.org/W2137824087","https://openalex.org/W2139574393","https://openalex.org/W2140716023","https://openalex.org/W2140889378","https://openalex.org/W2147000598","https://openalex.org/W2149655632","https://openalex.org/W2149830121","https://openalex.org/W2150547387","https://openalex.org/W2152630148","https://openalex.org/W2153046090","https://openalex.org/W2153049516","https://openalex.org/W2153983456","https://openalex.org/W2154192340","https://openalex.org/W2156973770","https://openalex.org/W2161018624","https://openalex.org/W2161087912","https://openalex.org/W2161535104","https://openalex.org/W2171606151","https://openalex.org/W2312260719","https://openalex.org/W2313674236","https://openalex.org/W2331174375","https://openalex.org/W2334664985","https://openalex.org/W2962895620","https://openalex.org/W2979245741","https://openalex.org/W4241182524","https://openalex.org/W4244370844","https://openalex.org/W4253345956"],"related_works":["https://openalex.org/W72117016","https://openalex.org/W2031493333","https://openalex.org/W4391911943","https://openalex.org/W1997862371","https://openalex.org/W1988320118","https://openalex.org/W2801953116","https://openalex.org/W3154850684","https://openalex.org/W4253608990","https://openalex.org/W3111438036","https://openalex.org/W2157469564"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}