{"id":"https://openalex.org/W2052349674","doi":"https://doi.org/10.3171/2009.11.jns081052","title":"Molecular mechanisms of microvascular failure in central nervous system injury\u2014synergistic roles of NKCC1 and SUR1/TRPM4","display_name":"Molecular mechanisms of microvascular failure in central nervous system injury\u2014synergistic roles of NKCC1 and SUR1/TRPM4","publication_year":2009,"publication_date":"2009-12-25","ids":{"openalex":"https://openalex.org/W2052349674","doi":"https://doi.org/10.3171/2009.11.jns081052","mag":"2052349674","pmid":"https://pubmed.ncbi.nlm.nih.gov/20035575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3032917"},"language":"en","primary_location":{"id":"doi:10.3171/2009.11.jns081052","doi":"https://doi.org/10.3171/2009.11.jns081052","is_oa":false,"landing_page_url":"https://doi.org/10.3171/2009.11.jns081052","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3032917","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073844022","display_name":"J. Marc Simard","orcid":"https://orcid.org/0000-0002-5373-1988","observed_orcids":["https://orcid.org/0000-0002-5373-1988","https://orcid.org/0000-0003-1161-3729"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Marc Simard","raw_affiliation_strings":["Departments of Neurosurgery,","Pathology, University of Maryland School of Medicine, Baltimore, Maryland; and","Physiology, and","3Pathology, University of Maryland School of Medicine, Baltimore, Maryland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery,","institution_ids":[]},{"raw_affiliation_string":"Pathology, University of Maryland School of Medicine, Baltimore, Maryland; and","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Physiology, and","institution_ids":[]},{"raw_affiliation_string":"3Pathology, University of Maryland School of Medicine, Baltimore, Maryland; and","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058936141","display_name":"Kristopher Thomas Kahle","orcid":"https://orcid.org/0000-0002-5922-7547","observed_orcids":["https://orcid.org/0000-0002-5922-7547"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristopher T. Kahle","raw_affiliation_strings":["Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","4Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"4Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039689256","display_name":"Volodymyr Gerzanich","orcid":"https://orcid.org/0000-0002-6714-1946","observed_orcids":["https://orcid.org/0000-0002-6714-1946"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Volodymyr Gerzanich","raw_affiliation_strings":["Departments of Neurosurgery,","1Departments of Neurosurgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery,","institution_ids":[]},{"raw_affiliation_string":"1Departments of Neurosurgery,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073844022"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":null,"apc_paid":null,"fwci":0.8148,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.59588299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"113","issue":"3","first_page":"622","last_page":"629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.16419999301433563,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nkcc1","display_name":"NKCC1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/capillary-permeability","display_name":"capillary permeability","score":0.7630000114440918},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ischemia-reperfusion","display_name":"ischemia-reperfusion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bumetanide","display_name":"bumetanide","score":0.8500000238418579},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2778212192","wikidata":"https://www.wikidata.org/wiki/Q275926","display_name":"Bumetanide","level":4,"score":0.8063945770263672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6847481727600098},{"id":"https://openalex.org/C2779493303","wikidata":"https://www.wikidata.org/wiki/Q979168","display_name":"Cerebral edema","level":2,"score":0.5531455874443054},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5187930464744568},{"id":"https://openalex.org/C90420996","wikidata":"https://www.wikidata.org/wiki/Q15324120","display_name":"TRPV4","level":4,"score":0.48580169677734375},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4781932830810547},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.4596092700958252},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4414820671081543},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.43195435404777527},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.4267219007015228},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.41297513246536255},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36069774627685547},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.34037452936172485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32143130898475647},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3151700794696808},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.2034757137298584},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18920236825942993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1753765046596527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1505565345287323},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10453858971595764},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024661","descriptor_name":"Potassium Channels, Inwardly Rectifying","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D028021","descriptor_name":"Sodium-Potassium-Chloride Symporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050053","descriptor_name":"TRPM Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064233","descriptor_name":"Sulfonylurea Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064506","descriptor_name":"Solute Carrier Family 12, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3171/2009.11.jns081052","doi":"https://doi.org/10.3171/2009.11.jns081052","is_oa":false,"landing_page_url":"https://doi.org/10.3171/2009.11.jns081052","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},{"id":"pmid:20035575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20035575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgery","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2038952","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3032917","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3032917","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3032917/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosurg","raw_type":"Text"},{"id":"mag:2389902710","doi":null,"is_oa":false,"landing_page_url":"https://thejns.org/doi/pdf/10.3171/2009.11.JNS081052","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2038952","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3032917","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5360641798","display_name":"Astrocyte regulation of the blood-brain barrier in intracerebral hemorrhage","funder_award_id":"R01HL082517","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7337410801","display_name":"TrpM4 channel in spinal cord injury","funder_award_id":"R01NS061934","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8925550715","display_name":"Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel","funder_award_id":"R01NS060801","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G961501906","display_name":"Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara","funder_award_id":"R01NS061808","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W178434341","https://openalex.org/W1561824693","https://openalex.org/W1822516711","https://openalex.org/W1902460967","https://openalex.org/W1910864442","https://openalex.org/W1927077456","https://openalex.org/W1936849452","https://openalex.org/W1957958801","https://openalex.org/W1964221757","https://openalex.org/W1975716726","https://openalex.org/W1978505795","https://openalex.org/W1978669570","https://openalex.org/W1982312219","https://openalex.org/W1990514899","https://openalex.org/W1996003447","https://openalex.org/W2000845410","https://openalex.org/W2003890250","https://openalex.org/W2009662334","https://openalex.org/W2016300886","https://openalex.org/W2019286511","https://openalex.org/W2020554150","https://openalex.org/W2025547429","https://openalex.org/W2034679108","https://openalex.org/W2035363671","https://openalex.org/W2036465941","https://openalex.org/W2037703396","https://openalex.org/W2041557159","https://openalex.org/W2043161274","https://openalex.org/W2043178444","https://openalex.org/W2047747930","https://openalex.org/W2051097680","https://openalex.org/W2051214272","https://openalex.org/W2057041797","https://openalex.org/W2064189557","https://openalex.org/W2068210639","https://openalex.org/W2068946296","https://openalex.org/W2079787007","https://openalex.org/W2087640478","https://openalex.org/W2097182515","https://openalex.org/W2099771668","https://openalex.org/W2100590935","https://openalex.org/W2103230981","https://openalex.org/W2105196805","https://openalex.org/W2105443363","https://openalex.org/W2106274476","https://openalex.org/W2117339662","https://openalex.org/W2118687598","https://openalex.org/W2119856586","https://openalex.org/W2125612952","https://openalex.org/W2136830984","https://openalex.org/W2137590176","https://openalex.org/W2142918726","https://openalex.org/W2143341711","https://openalex.org/W2148992136","https://openalex.org/W2166505057","https://openalex.org/W2167037697","https://openalex.org/W2187515179","https://openalex.org/W6639833409","https://openalex.org/W6640336333","https://openalex.org/W6644955968","https://openalex.org/W6650509828","https://openalex.org/W6652574008","https://openalex.org/W6656607015","https://openalex.org/W6659385618","https://openalex.org/W6660824228","https://openalex.org/W6661351499","https://openalex.org/W6663363618","https://openalex.org/W6672363613","https://openalex.org/W6676039242","https://openalex.org/W6677639878","https://openalex.org/W6684719246","https://openalex.org/W6684766092","https://openalex.org/W7168261170"],"related_works":["https://openalex.org/W2560014610","https://openalex.org/W2620694208","https://openalex.org/W2025547429","https://openalex.org/W2282035195","https://openalex.org/W1519585367","https://openalex.org/W2009662334","https://openalex.org/W2083581277","https://openalex.org/W7100090785","https://openalex.org/W2098678041","https://openalex.org/W1994134888"],"abstract_inverted_index":{"Microvascular":[0],"failure":[1],"largely":[2],"underlies":[3],"the":[4,20,65,72,104,141,166,192,201,206],"damaging":[5],"secondary":[6,36],"events":[7],"that":[8,101,162],"accompany":[9],"traumatic":[10],"brain":[11,56],"injury":[12],"(TBI).":[13],"Changes":[14],"in":[15,19,41,55,120,140,180,222],"capillary":[16,149,225],"permeability":[17],"result":[18],"extravasation":[21],"of":[22,44,62,86,117,125,136,144,183,209],"extracellular":[23],"fluid,":[24],"inflammatory":[25],"cells,":[26,146],"and":[27,34,46,71,113,151,154,165,185,189,194,200,216],"blood,":[28],"thereby":[29],"producing":[30],"cerebral":[31,187],"edema,":[32],"inflammation,":[33],"progressive":[35],"hemorrhage":[37],"(PSH).":[38],"Recent":[39],"work":[40],"rat":[42],"models":[43,182],"TBI":[45],"stroke":[47],"have":[48,175],"implicated":[49],"2":[50,157],"ion":[51],"transport":[52],"proteins":[53],"expressed":[54,67],"endothelial":[57,145],"cells":[58],"as":[59,109],"critical":[60,131,220],"mediators":[61],"edema":[63,122,188],"formation:":[64],"constitutively":[66],"Na(+)-K(+)-2Cl(-)":[68],"cotransporter,":[69],"NKCC1,":[70],"trauma/ischemia-induced":[73],"SUR1-regulated":[74],"NC(Ca-ATP)":[75],"(SUR1/TRPM4)":[76],"channel.":[77],"Whereas":[78],"NKCC1":[79,164,199],"function":[80],"requires":[81],"adenosine":[82],"5'-triphosphate":[83],"(ATP),":[84],"activation":[85],"SUR1/TRPM4":[87,137,167,202],"occurs":[88],"only":[89],"after":[90],"ATP":[91,98,110,132],"depletion.":[92],"This":[93],"opposite":[94],"dependence":[95],"on":[96],"intracellular":[97],"levels":[99],"implies":[100],"one":[102],"or":[103],"other":[105],"mechanism":[106],"will":[107],"activate/deactivate":[108],"concentrations":[111],"rise":[112],"fall":[114],"during":[115],"periods":[116],"ischemia/reperfusion,":[118],"resulting":[119],"continuous":[121],"formation":[123],"regardless":[124],"cellular":[126],"energy":[127],"status.":[128],"Moreover,":[129],"with":[130,214],"depletion,":[133],"sustained":[134],"opening":[135],"channels":[138],"results":[139],"oncotic":[142],"death":[143],"leading":[147],"to":[148,205],"fragmentation":[150],"PSH.":[152,190],"Bumetanide":[153],"glibenclamide":[155,217],"are":[156],"well-characterized,":[158],"safe,":[159],"FDA-approved":[160],"drugs":[161,174],"inhibit":[163],"channel,":[168],"respectively.":[169],"When":[170],"used":[171],"alone,":[172],"these":[173,210],"provided":[176],"documented":[177],"beneficial":[178],"effects":[179],"animal":[181],"TBI-":[184],"ischemiaassociated":[186],"Given":[191],"mechanistic":[193],"temporal":[195],"differences":[196],"by":[197],"which":[198],"channel":[203],"contribute":[204],"pathophysiological":[207],"mechanisms":[208],"events,":[211],"combination":[212],"therapy":[213],"bumetanide":[215],"may":[218],"yield":[219],"synergy":[221],"preventing":[223],"injury-associated":[224],"failure.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
