{"id":"https://openalex.org/W2052337706","doi":"https://doi.org/10.1056/nejm197505012921803","title":"Pancreatic Cholera: Beneficial Effects of Treatment with Streptozotocin","display_name":"Pancreatic Cholera: Beneficial Effects of Treatment with Streptozotocin","publication_year":1975,"publication_date":"1975-05-01","ids":{"openalex":"https://openalex.org/W2052337706","doi":"https://doi.org/10.1056/nejm197505012921803","mag":"2052337706","pmid":"https://pubmed.ncbi.nlm.nih.gov/163965"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197505012921803","doi":"https://doi.org/10.1056/nejm197505012921803","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197505012921803","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051737440","display_name":"C. Ronald Kahn","orcid":"https://orcid.org/0000-0002-7583-9228","observed_orcids":["https://orcid.org/0000-0002-7583-9228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Ronald Kahn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103543899","display_name":"Arnold G. Levy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnold G. Levy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010478795","display_name":"Jerry D. Gardner","orcid":"https://orcid.org/0000-0001-9642-864X","observed_orcids":["https://orcid.org/0000-0001-9642-864X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerry D. Gardner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049825346","display_name":"James V. Miller","orcid":"https://orcid.org/0000-0003-1877-7881","observed_orcids":["https://orcid.org/0000-0003-1877-7881"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James V. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070064147","display_name":"Phillip G\u00f6rden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip Gorden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062682753","display_name":"Philip S. Schein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip S. Schein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":20.3997,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.99518304,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"292","issue":"18","first_page":"941","last_page":"945"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.6807000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.6807000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.20559999346733093,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-cell-carcinoma","display_name":"islet cell carcinoma","score":0.890999972820282},{"id":"https://openalex.org/keywords/streptozotocin","display_name":"streptozotocin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/intra-arterial-chemotherapy","display_name":"intra-arterial chemotherapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.6370000243186951},{"id":"https://openalex.org/keywords/serum-potassium","display_name":"serum potassium","score":0.7229999899864197},{"id":"https://openalex.org/keywords/vasoactive-intestinal-peptide","display_name":"vasoactive intestinal peptide","score":0.9079999923706055},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/drug-extraction","display_name":"drug extraction","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8815057277679443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7251123189926147},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5729705691337585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5694131255149841},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.5411983132362366},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5263123512268066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47224658727645874},{"id":"https://openalex.org/C2781025020","wikidata":"https://www.wikidata.org/wiki/Q419935","display_name":"Octreotide","level":3,"score":0.4651094079017639},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45574474334716797},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.4418366849422455},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2719022035598755},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.08241012692451477},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000126","descriptor_name":"Achlorhydria","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002771","descriptor_name":"Cholera","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005768","descriptor_name":"Gastrointestinal Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007008","descriptor_name":"Hypokalemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007008","descriptor_name":"Hypokalemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007516","descriptor_name":"Adenoma, Islet Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007516","descriptor_name":"Adenoma, Islet Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm197505012921803","doi":"https://doi.org/10.1056/nejm197505012921803","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197505012921803","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:163965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/163965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1418093389","https://openalex.org/W1706803842","https://openalex.org/W1967612457","https://openalex.org/W1974820558","https://openalex.org/W1981696346","https://openalex.org/W1989233175","https://openalex.org/W2000879076","https://openalex.org/W2002853556","https://openalex.org/W2003356491","https://openalex.org/W2004433669","https://openalex.org/W2008574207","https://openalex.org/W2016798908","https://openalex.org/W2017539979","https://openalex.org/W2018746261","https://openalex.org/W2029112103","https://openalex.org/W2034328928","https://openalex.org/W2035715345","https://openalex.org/W2044936843","https://openalex.org/W2048074326","https://openalex.org/W2051488512","https://openalex.org/W2058650437","https://openalex.org/W2066959642","https://openalex.org/W2072093345","https://openalex.org/W2079110761","https://openalex.org/W2081349055","https://openalex.org/W2092169341","https://openalex.org/W2113358892","https://openalex.org/W2121880370","https://openalex.org/W2138243399","https://openalex.org/W2158734750","https://openalex.org/W2180146579","https://openalex.org/W2226892380","https://openalex.org/W2328267622","https://openalex.org/W2339772562","https://openalex.org/W2405381356","https://openalex.org/W2417117315","https://openalex.org/W2436394423","https://openalex.org/W4230528518","https://openalex.org/W4299148858","https://openalex.org/W4300010464","https://openalex.org/W4318445359"],"related_works":["https://openalex.org/W2022891862","https://openalex.org/W1987679857","https://openalex.org/W1488906966","https://openalex.org/W4289995467","https://openalex.org/W2008963171","https://openalex.org/W2009059575","https://openalex.org/W1979515830","https://openalex.org/W1964984587","https://openalex.org/W2031676065","https://openalex.org/W2414957540"],"abstract_inverted_index":{"Two":[0],"patients":[1],"with":[2,10,84],"pancreatic":[3],"cholera":[4],"and":[5,26,51,53,106,143],"islet-cell":[6],"carcinoma":[7],"were":[8],"treated":[9],"intra-arterial":[11],"streptozotocin.":[12],"Before":[13],"therapy,":[14],"they":[15],"had":[16,63,72],"stool":[17,49,79],"volumes":[18],"from":[19],"2":[20],"to":[21,29,39,92,147],"8":[22],"liters":[23],"per":[24,32,45,75],"day":[25,33],"required":[27],"200":[28],"800":[30],"mEq":[31],"of":[34,42,55,138],"supplemental":[35],"potassium.":[36],"After":[37,116],"three":[38],"five":[40],"doses":[41],"streptozotocin":[43,139],"(1.5":[44],"square":[46],"meter),":[47],"both":[48],"volume":[50,80],"number":[52],"size":[54],"hepatic":[56,134],"metastases":[57],"decreased":[58,144],"markedly.":[59],"One":[60],"patient":[61],"has":[62],"normally":[64],"formed":[65],"stools":[66],"for":[67,81,96],"12":[68],"months;":[69],"the":[70],"other":[71],"a":[73],"90":[74],"cent":[76],"reduction":[77],"in":[78,104,113],"13":[82],"months":[83],"additional":[85],"therapy.":[86],"Both":[87],"patients'":[88],"serum":[89],"potassium":[90],"returned":[91],"normal":[93,103],"without":[94],"need":[95],"supplementation.":[97],"Jejunal":[98],"adenylate":[99],"cyclase":[100],"activity":[101],"was":[102,111],"both,":[105],"plasma":[107],"vasoactive":[108],"intestinal":[109],"peptide":[110],"detectable":[112],"only":[114],"one.":[115],"chemotherapy,":[117],"these":[118],"findings":[119],"showed":[120],"no":[121],"consistent":[122],"change.":[123],"Pharmacologic":[124],"studies":[125],"suggest":[126],"that":[127],"arterial":[128],"administration":[129],"increased":[130],"either":[131],"tumor":[132],"or":[133],"extraction":[135],"(or":[136],"both)":[137],"by":[140,151],"two":[141],"times":[142],"renal":[145],"exposure":[146],"this":[148],"nephrotoxic":[149],"drug":[150],"one":[152],"third.":[153]},"counts_by_year":[{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
