{"id":"https://openalex.org/W2052293298","doi":"https://doi.org/10.1007/s00535-013-0780-7","title":"Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis","display_name":"Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis","publication_year":2013,"publication_date":"2013-03-19","ids":{"openalex":"https://openalex.org/W2052293298","doi":"https://doi.org/10.1007/s00535-013-0780-7","mag":"2052293298","pmid":"https://pubmed.ncbi.nlm.nih.gov/23512345","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3925298"},"language":"en","primary_location":{"id":"doi:10.1007/s00535-013-0780-7","doi":"https://doi.org/10.1007/s00535-013-0780-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00535-013-0780-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00535-013-0780-7.pdf","source":{"id":"https://openalex.org/S41046285","display_name":"Journal of Gastroenterology","issn_l":"0944-1174","issn":["0944-1174","1435-5922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00535-013-0780-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051560242","display_name":"Mina Hamano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mina Hamano","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013801548","display_name":"Hisao Ezaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisao Ezaki","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113945818","display_name":"Shinichi Kiso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinichi Kiso","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025096054","display_name":"Kunimaro Furuta","orcid":"https://orcid.org/0000-0001-6440-5929","observed_orcids":["https://orcid.org/0000-0001-6440-5929"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunimaro Furuta","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066105203","display_name":"Mayumi Egawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayumi Egawa","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047519369","display_name":"Takashi Kizu","orcid":"https://orcid.org/0009-0007-4025-5197","observed_orcids":["https://orcid.org/0009-0007-4025-5197"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Kizu","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114014784","display_name":"Norihiro Chatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norihiro Chatani","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064909021","display_name":"Yoshihiro Kamada","orcid":"https://orcid.org/0000-0001-5485-902X","observed_orcids":["https://orcid.org/0000-0001-5485-902X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Kamada","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024410377","display_name":"Yuichi Yoshida","orcid":"https://orcid.org/0000-0001-8855-4099","observed_orcids":["https://orcid.org/0000-0001-8855-4099"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Yoshida","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040891927","display_name":"Tetsuo Takehara","orcid":"https://orcid.org/0000-0001-5036-3457","observed_orcids":["https://orcid.org/0000-0001-5036-3457"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Takehara","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine, 2-2 K1, Yamada-oka, Suita, Osaka, 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology; Osaka University Graduate School of Medicine; Suita Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113945818"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":2.006,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.86151146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"49","issue":"2","first_page":"305","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.7670000195503235},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9200000166893005},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7689999938011169},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.871999979019165},{"id":"https://openalex.org/keywords/tauroursodeoxycholic-acid","display_name":"tauroursodeoxycholic acid","score":0.9710000157356262},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.871999979019165},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.7120000123977661},{"id":"https://openalex.org/keywords/intrahepatic-triglyceride","display_name":"intrahepatic triglyceride","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.8723400831222534},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.8291350603103638},{"id":"https://openalex.org/C2777422422","wikidata":"https://www.wikidata.org/wiki/Q7688907","display_name":"Tauroursodeoxycholic acid","level":4,"score":0.827799916267395},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6741206645965576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6618229746818542},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.565215528011322},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5394244194030762},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5251826047897339},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.474581241607666},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.45252034068107605},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.44405925273895264},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.2642146646976471},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21877583861351013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1878400444984436},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.18145692348480225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13114020228385925},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071701","descriptor_name":"Regulatory Factor X Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072278","descriptor_name":"Forkhead Box Protein M1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002756","descriptor_name":"Cholagogues and Choleretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013655","descriptor_name":"Taurochenodeoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056744","descriptor_name":"Cyclin B1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056751","descriptor_name":"Cyclin A2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00535-013-0780-7","doi":"https://doi.org/10.1007/s00535-013-0780-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00535-013-0780-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00535-013-0780-7.pdf","source":{"id":"https://openalex.org/S41046285","display_name":"Journal of Gastroenterology","issn_l":"0944-1174","issn":["0944-1174","1435-5922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2911916","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3925298","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3925298","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3925298","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gastroenterol","raw_type":"Text"},{"id":"pmid:23512345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23512345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00535-013-0780-7","doi":"https://doi.org/10.1007/s00535-013-0780-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00535-013-0780-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00535-013-0780-7.pdf","source":{"id":"https://openalex.org/S41046285","display_name":"Journal of Gastroenterology","issn_l":"0944-1174","issn":["0944-1174","1435-5922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G423129873","display_name":"Identification of Gab1 as a novel therapeutic target for hepatocellular carcinoma","funder_award_id":"23590974","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052293298.pdf","grobid_xml":"https://content.openalex.org/works/W2052293298.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1503173790","https://openalex.org/W1510533458","https://openalex.org/W1513453933","https://openalex.org/W1703945133","https://openalex.org/W1909027985","https://openalex.org/W1963788394","https://openalex.org/W1964231591","https://openalex.org/W1971988944","https://openalex.org/W1976461381","https://openalex.org/W1983833034","https://openalex.org/W1999228501","https://openalex.org/W2000595541","https://openalex.org/W2001218848","https://openalex.org/W2001837599","https://openalex.org/W2007987759","https://openalex.org/W2012168390","https://openalex.org/W2013813851","https://openalex.org/W2024257349","https://openalex.org/W2030901818","https://openalex.org/W2038360824","https://openalex.org/W2041044388","https://openalex.org/W2042386759","https://openalex.org/W2047855070","https://openalex.org/W2048456744","https://openalex.org/W2054128877","https://openalex.org/W2056739101","https://openalex.org/W2057256337","https://openalex.org/W2062657417","https://openalex.org/W2063614264","https://openalex.org/W2066600483","https://openalex.org/W2068691871","https://openalex.org/W2070630275","https://openalex.org/W2072318850","https://openalex.org/W2080120151","https://openalex.org/W2088637473","https://openalex.org/W2090839709","https://openalex.org/W2091459334","https://openalex.org/W2101951251","https://openalex.org/W2110878347","https://openalex.org/W2120242770","https://openalex.org/W2120565320","https://openalex.org/W2128057304","https://openalex.org/W2145631502","https://openalex.org/W2149972103","https://openalex.org/W2157177585","https://openalex.org/W2168526937","https://openalex.org/W2171293990","https://openalex.org/W2247149472","https://openalex.org/W2253575964","https://openalex.org/W4254164242"],"related_works":["https://openalex.org/W2804159773","https://openalex.org/W2512579147","https://openalex.org/W2810948203","https://openalex.org/W1972889183","https://openalex.org/W2084668010","https://openalex.org/W2110878347","https://openalex.org/W2774082396","https://openalex.org/W2088637473","https://openalex.org/W1703945133","https://openalex.org/W4327857182"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIM:":[2],"Impaired":[3],"fatty":[4],"liver":[5,30,43,60,94,124,171,198,221,232],"regeneration":[6,31,44,95,199,233],"has":[7],"already":[8],"been":[9],"reported":[10],"in":[11,17,45,151,154,165,178,191,203,217,241],"many":[12],"genetic":[13],"modification":[14],"models.":[15],"However,":[16],"diet-induced":[18,48],"simple":[19,49,225],"hepatic":[20,50,226],"steatosis,":[21,51,227],"which":[22,113],"showed":[23],"similar":[24],"phenotype":[25],"with":[26,47,106,210],"clinical":[27],"pathology,":[28],"whether":[29],"is":[32],"impaired":[33],"or":[34,70],"not":[35],"remains":[36],"unclear.":[37],"In":[38,99,206,224],"this":[39],"study,":[40],"we":[41,119],"evaluated":[42],"mice":[46,103,180],"and":[52,83,90,117,142,215,239],"focused":[53],"on":[54,123],"excess":[55],"lipid":[56,79,228],"accumulation":[57],"occurring":[58,230],"during":[59,93,197,231],"regeneration.":[61,125,222],"METHODS:":[62],"Mice":[63],"were":[64,104,149,173],"fed":[65],"high":[66],"fat":[67],"diet":[68,72],"(HFD)":[69],"control":[71],"for":[73],"9-10":[74],"weeks.":[75],"We":[76],"analyzed":[77],"intrahepatic":[78],"accumulation,":[80],"DNA":[81,244],"replication,":[82],"various":[84],"signaling":[85],"pathways":[86],"including":[87],"cell":[88,137,146],"proliferation":[89,136],"ER":[91,115,194,213,237],"stress":[92,195,214,238],"after":[96],"partial":[97],"hepatectomy.":[98],"addition,":[100],"some":[101],"of":[102,129,135,145,159,170,219],"pretreated":[105],"tauroursodeoxycholic":[107],"acid":[108,187],"(TUDCA),":[109],"a":[110],"chemical":[111],"chaperone":[112],"alleviates":[114],"stress,":[116],"then":[118],"estimated":[120],"TUDCA":[121,211],"effects":[122],"RESULTS:":[126],"The":[127,157,168],"peak":[128],"hepatocyte":[130,243],"BrdU":[131],"incorporation,":[132],"the":[133,143],"expression":[134,158],"nuclear":[138],"antigen":[139],"(PCNA)":[140],"protein,":[141],"expressions":[144],"cycle-related":[147],"genes":[148],"observed":[150],"delayed":[152,164,220,242],"time":[153,183],"HFD":[155,166,179,192,204,207],"mice.":[156,167,193,205],"phosphorylated":[160],"Erk1/2":[161],"was":[162,188,200],"also":[163],"amounts":[169],"triglyceride":[172],"at":[174,181],"least":[175],"twofold":[176],"higher":[177,202],"each":[182],"point.":[184],"Intrahepatic":[185],"palmitic":[186],"increased":[189],"especially":[190],"induced":[196],"significantly":[201],"mice,":[208],"pretreatment":[209],"reduced":[212],"resulted":[216],"improvement":[218],"CONCLUSION:":[223],"overloading":[229],"might":[234],"be":[235],"caused":[236],"results":[240],"replication.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}