{"id":"https://openalex.org/W2052289281","doi":"https://doi.org/10.1055/s-0034-1367060","title":"Triiodothyronine Induces Proliferation of Pancreatic \u03b2-cells through the MAPK/ERK Pathway","display_name":"Triiodothyronine Induces Proliferation of Pancreatic \u03b2-cells through the MAPK/ERK Pathway","publication_year":2014,"publication_date":"2014-03-12","ids":{"openalex":"https://openalex.org/W2052289281","doi":"https://doi.org/10.1055/s-0034-1367060","mag":"2052289281","pmid":"https://pubmed.ncbi.nlm.nih.gov/24623499"},"language":"en","primary_location":{"id":"doi:10.1055/s-0034-1367060","doi":"https://doi.org/10.1055/s-0034-1367060","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1367060","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology & Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"T. Kim","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416292","display_name":"Ji Hoon Lee","orcid":"https://orcid.org/0000-0002-7488-3999","observed_orcids":["https://orcid.org/0000-0002-7488-3999"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"J. Lee","raw_affiliation_strings":["Paik Institute for Clinical Research, Molecular Therapy Lab, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paik Institute for Clinical Research, Molecular Therapy Lab, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101908658","display_name":"Hye Sook Jung","orcid":"https://orcid.org/0000-0001-7940-7249","observed_orcids":["https://orcid.org/0000-0001-7940-7249"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"H. Jung","raw_affiliation_strings":["Paik Institute for Clinical Research, Molecular Therapy Lab, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paik Institute for Clinical Research, Molecular Therapy Lab, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101414022","display_name":"Trung Quang Ha","orcid":"https://orcid.org/0000-0001-7980-3700","observed_orcids":["https://orcid.org/0000-0001-7980-3700"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"T. Ha","raw_affiliation_strings":["Department of General Surgery, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016285288","display_name":"Tae Nyun Kim","orcid":"https://orcid.org/0000-0001-6568-2469","observed_orcids":["https://orcid.org/0000-0001-6568-2469"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. Kim","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"N. Han","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364598","display_name":"Eun\u2010Ju Lee","orcid":"https://orcid.org/0000-0001-9446-1059","observed_orcids":["https://orcid.org/0000-0001-9446-1059"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"E. Lee","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"T. Kim","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027011598","display_name":"Min Jeong Kwon","orcid":"https://orcid.org/0000-0002-9616-870X","observed_orcids":["https://orcid.org/0000-0002-9616-870X"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"M. Kwon","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. Lee","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100646687","display_name":"Mi-Kyung Kim","orcid":"https://orcid.org/0000-0003-1111-9122","observed_orcids":["https://orcid.org/0000-0003-1111-9122"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"M. Kim","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018157819","display_name":"Byoung Doo Rhee","orcid":"https://orcid.org/0000-0002-9459-3227","observed_orcids":["https://orcid.org/0000-0002-9459-3227"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"B. Rhee","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100667208","display_name":"Junho Park","orcid":"https://orcid.org/0000-0002-0776-3188","observed_orcids":["https://orcid.org/0000-0002-0776-3188"]},"institutions":[{"id":"https://openalex.org/I104338594","display_name":"Inje University","ror":"https://ror.org/04xqwq985","country_code":"KR","type":"education","lineage":["https://openalex.org/I104338594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"J. Park","raw_affiliation_strings":["Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","Paik Institute for Clinical Research, Molecular Therapy Lab, Inje University, Busan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, College of Medicine, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]},{"raw_affiliation_string":"Paik Institute for Clinical Research, Molecular Therapy Lab, Inje University, Busan, Korea","institution_ids":["https://openalex.org/I104338594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I104338594"],"apc_list":null,"apc_paid":null,"fwci":4.1934,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.93948932,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"122","issue":"04","first_page":"240","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/beta-cell-proliferation","display_name":"beta-cell proliferation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.984000027179718},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-alpha","display_name":"thyroid hormone receptor alpha","score":0.7559999823570251},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-beta","display_name":"thyroid hormone receptor beta","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ins-1-cells","display_name":"INS-1 cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8930000066757202},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9700000286102295},{"id":"https://openalex.org/keywords/akt-pathway","display_name":"AKT pathway","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8234755396842957},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6406211256980896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47649258375167847},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46283984184265137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4572027623653412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44015198945999146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37864845991134644},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3617978096008301},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3328068256378174},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1571180522441864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1285775899887085}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0034-1367060","doi":"https://doi.org/10.1055/s-0034-1367060","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1367060","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology & Diabetes","raw_type":"journal-article"},{"id":"pmid:24623499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24623499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2361792103","https://openalex.org/W2589983708","https://openalex.org/W2137969630","https://openalex.org/W2749399223","https://openalex.org/W2009037891","https://openalex.org/W1521411817","https://openalex.org/W2360066506","https://openalex.org/W1982459028","https://openalex.org/W2367042309","https://openalex.org/W772272767"],"abstract_inverted_index":{"BACKGROUND:":[0],"3,5,3'-Triiodothyronine":[1],"(T3)":[2],"has":[3],"a":[4,66,161,167],"stimulatory":[5],"effect":[6],"on":[7],"cellular":[8],"growth":[9],"via":[10,170],"thyroid":[11],"hormone":[12],"receptors":[13],"(TRs)":[14],"in":[15,21,73,84,166,189],"several":[16],"cell":[17,28,48,125,146,158,195],"lines.":[18],"TR":[19],"expression":[20,120],"the":[22,51,171,190],"pancreas":[23],"suggests":[24],"that":[25,43,182],"pancreatic":[26,46,193],"beta":[27,47,194],"proliferation":[29,49,115,159],"might":[30],"be":[31],"induced":[32,192],"by":[33,123,142,150],"T3.":[34],"The":[35,133],"purpose":[36],"of":[37,70,111,163],"this":[38],"study":[39],"was":[40,148],"to":[41,93,98],"demonstrate":[42,181],"T3":[44,96,155,191],"induces":[45],"through":[50],"mitogen":[52],"activated":[53],"protein":[54],"kinase/extracellular":[55],"regulated":[56],"kinase":[57],"(MAPK/ERK)":[58],"pathway.":[59],"METHODS:":[60],"INS-1":[61,157],"cells":[62,102],"were":[63,91,103,121,140],"plated":[64],"as":[65],"monolayer":[67],"at":[68,160],"densities":[69],"4\u00d7104,":[71],"cultured":[72],"RPMI":[74],"1,640":[75],"with":[76,81],"10%":[77],"fetal":[78],"bovine":[79],"serum":[80],"2-mercaptoethanol,":[82],"respectively,":[83],"6-well":[85],"multiplates.":[86],"After":[87],"48":[88],"h,":[89],"they":[90],"exposed":[92],"10-7":[94,164],"M":[95,165],"or":[97],"vehicle":[99],"alone.":[100],"Viable":[101],"harvested":[104],"after":[105],"24,":[106],"48,":[107],"and":[108,116,118,130,137,174],"72":[109],"h":[110],"continuous":[112],"exposure.":[113],"Cell":[114],"TR\u03b11":[117],"TR\u03b21":[119],"analyzed":[122,141],"flow-assisted":[124],"sorting":[126],"analysis,":[127],"Ki-67":[128],"staining,":[129],"Western":[131,143],"blotting.":[132,144],"p38":[134],"MAPK,":[135],"ERK,":[136],"Akt":[138],"pathways":[139],"Beta":[145],"function":[147],"evaluated":[149],"assaying":[151],"insulin":[152,176],"secretion.":[153,177],"RESULTS:":[154],"enhanced":[156],"dose":[162],"time-dependent":[168],"manner":[169],"MAPK/ERK":[172,183],"pathway":[173,184],"promoted":[175],"CONCLUSIONS:":[178],"Our":[179],"results":[180],"plays":[185],"an":[186],"important":[187],"role":[188],"proliferation.":[196]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}