{"id":"https://openalex.org/W2052287368","doi":"https://doi.org/10.1097/01.mpa.0000335359.09266.f7","title":"LY6Chi MONOCYTES MIGRATE TO THE PANCREAS DURING PANCREATITIS AND REGULATE ITS SEVERITY","display_name":"LY6Chi MONOCYTES MIGRATE TO THE PANCREAS DURING PANCREATITIS AND REGULATE ITS SEVERITY","publication_year":2008,"publication_date":"2008-10-22","ids":{"openalex":"https://openalex.org/W2052287368","doi":"https://doi.org/10.1097/01.mpa.0000335359.09266.f7","mag":"2052287368"},"language":"en","primary_location":{"id":"doi:10.1097/01.mpa.0000335359.09266.f7","doi":"https://doi.org/10.1097/01.mpa.0000335359.09266.f7","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpa.0000335359.09266.f7","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042075267","display_name":"George Perides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Perides","raw_affiliation_strings":["Department of Surgery, Tufts Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tufts Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006288518","display_name":"Johanna Laukkarinen","orcid":"https://orcid.org/0000-0002-8239-4861","observed_orcids":["https://orcid.org/0000-0002-8239-4861"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Laukkarinen","raw_affiliation_strings":["Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080575738","display_name":"Jeremy S. Duffield","orcid":"https://orcid.org/0000-0002-3838-0630","observed_orcids":["https://orcid.org/0000-0002-3838-0630"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Duffield","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089990723","display_name":"Michael L. Steer","orcid":"https://orcid.org/0000-0002-5365-8215","observed_orcids":["https://orcid.org/0000-0002-5365-8215"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Steer","raw_affiliation_strings":["Department of Surgery, Tufts Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tufts Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19511524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"4","first_page":"489","last_page":"489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ly6c-high-monocytes","display_name":"Ly6Chi monocytes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.746999979019165},{"id":"https://openalex.org/keywords/monocyte-depletion","display_name":"monocyte depletion","score":0.8629999756813049},{"id":"https://openalex.org/keywords/monocyte-trafficking","display_name":"monocyte trafficking","score":0.7739999890327454},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.609000027179718},{"id":"https://openalex.org/keywords/bone-marrow-cells","display_name":"bone marrow cells","score":0.6610000133514404},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/diphtheria-toxin-receptor","display_name":"diphtheria toxin receptor","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cerulein-induced-pancreatitis","display_name":"cerulein-induced pancreatitis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/inflammation-severity","display_name":"inflammation severity","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.7514761686325073},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.6913257837295532},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6767575740814209},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5999200940132141},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5834671258926392},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.5457857847213745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5370612740516663},{"id":"https://openalex.org/C33057221","wikidata":"https://www.wikidata.org/wiki/Q421580","display_name":"Diphtheria toxin","level":3,"score":0.4921559691429138},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44777509570121765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3261171579360962},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3195357918739319},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.29607197642326355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2651321291923523},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.09137332439422607},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07905185222625732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.mpa.0000335359.09266.f7","doi":"https://doi.org/10.1097/01.mpa.0000335359.09266.f7","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.mpa.0000335359.09266.f7","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077619015","https://openalex.org/W2016895203","https://openalex.org/W2922701142","https://openalex.org/W4303968649","https://openalex.org/W4312123402","https://openalex.org/W2042496647","https://openalex.org/W4411152155","https://openalex.org/W2582999715","https://openalex.org/W3194808817","https://openalex.org/W2075708296"],"abstract_inverted_index":{"Introduction:":[0],"Monocyte":[1,91],"depletion":[2,92],"reduces":[3],"pancreatitis":[4,69,94,177,206],"severity":[5,95,105,119,178],"but":[6,96],"the":[7,26,33,66,113,124,134,140,148,166,182,186,190,200,203],"cell":[8,115],"sub-type":[9],"and":[10],"mechanisms":[11],"responsible":[12],"for":[13],"this":[14],"effect":[15],"are":[16,197],"unknown.":[17],"Methods:":[18],"We":[19,71],"gave":[20],"diphtheria":[21,28],"toxin":[22,29],"to":[23,32,36,45,123,139,161,181],"mice":[24],"expressing":[25],"human":[27],"receptor":[30],"coupled":[31],"CD11b":[34],"promoter":[35],"deplete":[37],"monocytes.":[38],"Caerulein":[39],"was":[40,61,120],"given":[41],"16":[42],"hrs":[43,64],"later":[44],"induce":[46],"pancreatitis.":[47],"Adoptive":[48],"transfer":[49,98,156],"of":[50,68,99,118,126,133,151,157,169,193,205],"peripheral":[51],"blood":[52],"mononuclear":[53],"cells":[54,59,78,86,108,159,195],"(PBMC)":[55],"or":[56,82,101],"bone":[57],"marrow":[58],"(BMC)":[60],"performed":[62],"4-6":[63],"after":[65],"start":[67],"induction.":[70,207],"monitored":[72],"monocyte":[73],"trafficking":[74],"by":[75,83,143,179],"pre-labelling":[76],"donor":[77],"with":[79],"CFSE,":[80],"111In,":[81],"transferring":[84],"CD45.1":[85],"into":[87,189],"CD45.2":[88],"recipients.":[89],"Results:":[90],"reduced":[93],"adoptive":[97,155],"PBMCs":[100],"BMCs":[102,137],"restored":[103],"that":[104,196],"unless":[106],"Ly6Chi":[107,129,153,171,174],"had":[109],"been":[110],"removed":[111],"from":[112],"transferred":[114,128,136],"pool.":[116],"Restoration":[117],"directly":[121],"proportional":[122],"number":[125,168],"adoptively":[127],"cells.":[130,172],"Only":[131],"3-4%":[132],"donor-derived,":[135],"trafficked":[138],"pancreas":[141,183,201],"but,":[142],"triggering":[144,185],"an":[145],"increase":[146,164],"in":[147,165,199],"pancreatic":[149],"content":[150],"recipient-derived":[152],"cells,":[154],"Ly-6Chi":[158,191],"led":[160],"a":[162],"large":[163],"total":[167],"intrapancreatic":[170],"Conclusions:":[173],"monocytes":[175],"regulate":[176],"migrating":[180],"and/or":[184],"phenotypic":[187],"transformation,":[188],"subset,":[192],"other":[194],"already":[198],"at":[202],"time":[204]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
