{"id":"https://openalex.org/W2052279754","doi":"https://doi.org/10.1073/pnas.171308498","title":"Identification of a family of Fc receptor homologs with preferential B cell expression","display_name":"Identification of a family of Fc receptor homologs with preferential B cell expression","publication_year":2001,"publication_date":"2001-08-07","ids":{"openalex":"https://openalex.org/W2052279754","doi":"https://doi.org/10.1073/pnas.171308498","mag":"2052279754","pmid":"https://pubmed.ncbi.nlm.nih.gov/11493702"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.171308498","doi":"https://doi.org/10.1073/pnas.171308498","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.171308498","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/55528","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012147802","display_name":"Randall S. Davis","orcid":"https://orcid.org/0000-0003-1906-8219","observed_orcids":["https://orcid.org/0000-0003-1906-8219"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall S. Davis","raw_affiliation_strings":["Divisions of Hematology/Oncology and Developmental and Clinical Immunology, Departments of Medicine, Pathology, Pediatrics, and Microbiology, and Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology/Oncology and Developmental and Clinical Immunology, Departments of Medicine, Pathology, Pediatrics, and Microbiology, and Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I17301866","https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054742445","display_name":"Yui\u2010Hsi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yui-Hsi Wang","raw_affiliation_strings":["Divisions of Hematology/Oncology and Developmental and Clinical Immunology, Departments of Medicine, Pathology, Pediatrics, and Microbiology, and Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology/Oncology and Developmental and Clinical Immunology, Departments of Medicine, Pathology, Pediatrics, and Microbiology, and Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I17301866","https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086631715","display_name":"Hiromi Kubagawa","orcid":"https://orcid.org/0000-0001-7195-706X","observed_orcids":["https://orcid.org/0000-0001-7195-706X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiromi Kubagawa","raw_affiliation_strings":["Divisions of Hematology/Oncology and Developmental and Clinical Immunology, Departments of Medicine, Pathology, Pediatrics, and Microbiology, and Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology/Oncology and Developmental and Clinical Immunology, Departments of Medicine, Pathology, Pediatrics, and Microbiology, and Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I17301866","https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031308976","display_name":"Max D. Cooper","orcid":"https://orcid.org/0000-0003-0887-8785","observed_orcids":["https://orcid.org/0000-0003-0887-8785"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max D. Cooper","raw_affiliation_strings":["Divisions of Hematology/Oncology and Developmental and Clinical Immunology, Departments of Medicine, Pathology, Pediatrics, and Microbiology, and Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Hematology/Oncology and Developmental and Clinical Immunology, Departments of Medicine, Pathology, Pediatrics, and Microbiology, and Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294-3300","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I17301866","https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.229,"has_fulltext":false,"cited_by_count":217,"citation_normalized_percentile":{"value":0.98959274,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"98","issue":"17","first_page":"9772","last_page":"9777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.12300000339746475,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.7089999914169312},{"id":"https://openalex.org/keywords/immunoglobulin-superfamily","display_name":"immunoglobulin superfamily","score":0.8339999914169312},{"id":"https://openalex.org/keywords/chromosome-1q21","display_name":"chromosome 1q21","score":0.9340000152587891},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.6729999780654907},{"id":"https://openalex.org/keywords/b-cell-lineage","display_name":"B-cell lineage","score":0.6940000057220459},{"id":"https://openalex.org/keywords/itam","display_name":"ITAM","score":0.8450000286102295},{"id":"https://openalex.org/keywords/itim","display_name":"ITIM","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gene-family-evolution","display_name":"gene family evolution","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7762817740440369},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6897651553153992},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.6626971364021301},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6476101875305176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5730310082435608},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5426559448242188},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.5368154048919678},{"id":"https://openalex.org/C29907709","wikidata":"https://www.wikidata.org/wiki/Q6005558","display_name":"Immunoreceptor tyrosine-based activation motif","level":5,"score":0.448057621717453},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4299657344818115},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3667217493057251},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3550613522529602},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.1745796501636505},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.11181443929672241}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002888","descriptor_name":"Chromosomes, Human, Pair 19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002888","descriptor_name":"Chromosomes, Human, Pair 19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002888","descriptor_name":"Chromosomes, Human, Pair 19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.171308498","doi":"https://doi.org/10.1073/pnas.171308498","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.171308498","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:11493702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11493702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:55528","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/55528","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:55528","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/55528","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1155497208","display_name":null,"funder_award_id":"AI39816","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1315744253","display_name":null,"funder_award_id":"R01 AI042127","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1535630676","display_name":null,"funder_award_id":"AI42127","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4349163744","display_name":"Comparison of B Cell Differentiation in Mice and Humans","funder_award_id":"R37AI039816","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G622398293","display_name":null,"funder_award_id":"R01 AI039816","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1503502817","https://openalex.org/W1529827491","https://openalex.org/W1530763286","https://openalex.org/W1551029743","https://openalex.org/W1574117887","https://openalex.org/W1591208477","https://openalex.org/W1763097249","https://openalex.org/W1827966419","https://openalex.org/W1903287340","https://openalex.org/W1907937104","https://openalex.org/W1966930760","https://openalex.org/W1968902433","https://openalex.org/W1973249742","https://openalex.org/W1974753304","https://openalex.org/W1976358306","https://openalex.org/W1981036521","https://openalex.org/W1984724325","https://openalex.org/W1989237539","https://openalex.org/W1999932257","https://openalex.org/W2001943758","https://openalex.org/W2008973880","https://openalex.org/W2014284991","https://openalex.org/W2017504214","https://openalex.org/W2030793757","https://openalex.org/W2031209863","https://openalex.org/W2037150903","https://openalex.org/W2055043387","https://openalex.org/W2062028511","https://openalex.org/W2077111637","https://openalex.org/W2086368089","https://openalex.org/W2087383120","https://openalex.org/W2091943511","https://openalex.org/W2106258670","https://openalex.org/W2110036277","https://openalex.org/W2114083522","https://openalex.org/W2116611972","https://openalex.org/W2120256127","https://openalex.org/W2120553565","https://openalex.org/W2136078012","https://openalex.org/W2138879032","https://openalex.org/W2143923297","https://openalex.org/W2147246240","https://openalex.org/W2151536565","https://openalex.org/W2154901790","https://openalex.org/W2158449767","https://openalex.org/W2161243339","https://openalex.org/W2171091522","https://openalex.org/W2172180689","https://openalex.org/W2172393633","https://openalex.org/W4249736906"],"related_works":["https://openalex.org/W3099772455","https://openalex.org/W3172198228","https://openalex.org/W1986078734","https://openalex.org/W2129301794","https://openalex.org/W1540599686","https://openalex.org/W2016396528","https://openalex.org/W2768023669","https://openalex.org/W2261012589","https://openalex.org/W4377101717","https://openalex.org/W1925092754"],"abstract_inverted_index":{"Investigation":[0],"of":[1,16,23,26,54,69,144,154,163],"human":[2],"genome":[3],"sequences":[4],"with":[5,80,112,120],"a":[6,24,47],"consensus":[7,89],"sequence":[8],"derived":[9],"from":[10],"receptors":[11],"for":[12],"the":[13,21,34,52,63,148,161],"Fc":[14,35],"region":[15,50],"Igs":[17],"(FcR)":[18],"led":[19],"to":[20],"identification":[22],"subfamily":[25],"five":[27,98],"Ig":[28],"superfamily":[29],"members":[30,68,162],"that":[31,160],"we":[32],"term":[33],"receptor":[36],"homologs":[37],"(FcRHs).":[38],"The":[39,97,125],"closely":[40],"linked":[41],"FcRH":[42,99,126,165],"genes":[43,100,127],"are":[44,101,128],"located":[45],"in":[46,51,173],"chromosome":[48],"1q21":[49],"midst":[53],"previously":[55],"recognized":[56],"FcR":[57,123],"genes.":[58],"This":[59],"report":[60],"focuses":[61],"on":[62],"FcRH1,":[64],"FcRH2,":[65],"and":[66,85,104,147,150,175],"FcRH3":[67],"this":[70,164],"gene":[71],"family.":[72],"Their":[73,139],"cDNAs":[74],"encode":[75],"type":[76],"I":[77],"transmembrane":[78,156],"glycoproteins":[79],"3-6":[81],"Ig-like":[82],"extracellular":[83,110],"domains":[84,87],"cytoplasmic":[86],"containing":[88],"immunoreceptor":[90],"tyrosine-based":[91],"activating":[92,151],"and/or":[93],"inhibitory":[94,149],"signaling":[95,152],"motifs.":[96],"structurally":[102],"related,":[103],"their":[105,121,155],"protein":[106,157],"products":[107,158],"share":[108,117],"28-60%":[109],"identity":[111,119],"each":[113],"other.":[114],"They":[115],"also":[116],"15-31%":[118],"closest":[122],"relatives.":[124],"expressed":[129],"primarily,":[130],"although":[131],"not":[132],"exclusively,":[133],"by":[134],"mature":[135],"B":[136,177],"lineage":[137],"cells.":[138],"conserved":[140],"structural":[141],"features,":[142],"patterns":[143],"cellular":[145],"expression,":[146],"potential":[153],"suggest":[159],"multigene":[166],"family":[167],"may":[168],"serve":[169],"important":[170],"regulatory":[171],"roles":[172],"normal":[174],"neoplastic":[176],"cell":[178],"development.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}