{"id":"https://openalex.org/W2052277746","doi":"https://doi.org/10.1016/0002-9343(60)90082-6","title":"A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog","display_name":"A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog","publication_year":1960,"publication_date":"1960-12-01","ids":{"openalex":"https://openalex.org/W2052277746","doi":"https://doi.org/10.1016/0002-9343(60)90082-6","mag":"2052277746","pmid":"https://pubmed.ncbi.nlm.nih.gov/13710014"},"language":"en","primary_location":{"id":"doi:10.1016/0002-9343(60)90082-6","doi":"https://doi.org/10.1016/0002-9343(60)90082-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0002-9343(60)90082-6","pdf_url":null,"source":{"id":"https://openalex.org/S186920367","display_name":"The American Journal of Medicine","issn_l":"0002-9343","issn":["0002-9343","1555-7162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113728964","display_name":"Aron Gutman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.B. Gutman","raw_affiliation_strings":["New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110005204","display_name":"Peter G. Dayton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.G. Dayton","raw_affiliation_strings":["New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065730009","display_name":"Tzu\u2010Ying Yu","orcid":"https://orcid.org/0000-0002-6724-6043","observed_orcids":["https://orcid.org/0000-0002-6724-6043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T.F. Y\u00fc","raw_affiliation_strings":["New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Berger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Berger","raw_affiliation_strings":["New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056508868","display_name":"W. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Chen","raw_affiliation_strings":["New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033433357","display_name":"Leonardo E. Sicam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L.E. Sicam","raw_affiliation_strings":["New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, New York, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111721573","display_name":"John Joseph Burns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.J. Burns","raw_affiliation_strings":["New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, New York, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3770,"currency":"USD","value_usd":3770},"apc_paid":null,"fwci":6.8925,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.96550459,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"29","issue":"6","first_page":"1017","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.21400000154972076,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pka","display_name":"pKa","score":0.8199999928474426},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.9850000143051147},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tubular-secretion","display_name":"renal tubular secretion","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tubular-reabsorption","display_name":"tubular reabsorption","score":0.968999981880188},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.7310000061988831},{"id":"https://openalex.org/keywords/urine-ph","display_name":"urine pH","score":0.6349999904632568},{"id":"https://openalex.org/keywords/organic-acids","display_name":"organic acids","score":0.5809999704360962},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.47200000286102295},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.527999997138977},{"id":"https://openalex.org/keywords/lipid-solubility","display_name":"lipid solubility","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.3269999921321869},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9463847875595093},{"id":"https://openalex.org/C2775844104","wikidata":"https://www.wikidata.org/wiki/Q421342","display_name":"Phenylbutazone","level":2,"score":0.7765527963638306},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6461050510406494},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.5352231860160828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4642542004585266},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4635927081108093},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34943801164627075},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.28662240505218506}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010653","descriptor_name":"Phenylbutazone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D065667","descriptor_name":"Renal Elimination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0002-9343(60)90082-6","doi":"https://doi.org/10.1016/0002-9343(60)90082-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0002-9343(60)90082-6","pdf_url":null,"source":{"id":"https://openalex.org/S186920367","display_name":"The American Journal of Medicine","issn_l":"0002-9343","issn":["0002-9343","1555-7162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:13710014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13710014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W82613300","https://openalex.org/W157997765","https://openalex.org/W1498869307","https://openalex.org/W1513525944","https://openalex.org/W1581995910","https://openalex.org/W1829487208","https://openalex.org/W1843613368","https://openalex.org/W1888612597","https://openalex.org/W1980147496","https://openalex.org/W1986588578","https://openalex.org/W1991600879","https://openalex.org/W2004958716","https://openalex.org/W2008663663","https://openalex.org/W2029289710","https://openalex.org/W2035448276","https://openalex.org/W2053622155","https://openalex.org/W2057831580","https://openalex.org/W2067411920","https://openalex.org/W2067424614","https://openalex.org/W2069102079","https://openalex.org/W2070983787","https://openalex.org/W2081627040","https://openalex.org/W2083114543","https://openalex.org/W2090872409","https://openalex.org/W2093445350","https://openalex.org/W2124374455","https://openalex.org/W2134113911","https://openalex.org/W2146351587","https://openalex.org/W2147926047","https://openalex.org/W2159871255","https://openalex.org/W2247938431","https://openalex.org/W2252991923","https://openalex.org/W2257292246","https://openalex.org/W2278143602","https://openalex.org/W2300601496","https://openalex.org/W2300616727","https://openalex.org/W2316251246","https://openalex.org/W2332795709","https://openalex.org/W2396550745","https://openalex.org/W2408448812","https://openalex.org/W2410628152","https://openalex.org/W2413457088","https://openalex.org/W2414172363","https://openalex.org/W2436627099","https://openalex.org/W2474633938","https://openalex.org/W2531898096","https://openalex.org/W2566021413","https://openalex.org/W2967230300","https://openalex.org/W3120938738","https://openalex.org/W4205141573","https://openalex.org/W4244587520","https://openalex.org/W4255252515","https://openalex.org/W4298190585","https://openalex.org/W6639285605","https://openalex.org/W6647183209"],"related_works":["https://openalex.org/W2300651443","https://openalex.org/W1915680045","https://openalex.org/W2346149805","https://openalex.org/W2415840495","https://openalex.org/W2056961183","https://openalex.org/W2411096030","https://openalex.org/W1993408284","https://openalex.org/W2462802811","https://openalex.org/W2305880550","https://openalex.org/W2167478227"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
