{"id":"https://openalex.org/W2052275446","doi":"https://doi.org/10.1016/j.jbiomech.2007.12.008","title":"Coupled modeling of blood perfusion in intravascular, interstitial spaces in tumor microvasculature","display_name":"Coupled modeling of blood perfusion in intravascular, interstitial spaces in tumor microvasculature","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2052275446","doi":"https://doi.org/10.1016/j.jbiomech.2007.12.008","mag":"2052275446","pmid":"https://pubmed.ncbi.nlm.nih.gov/18222455"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbiomech.2007.12.008","doi":"https://doi.org/10.1016/j.jbiomech.2007.12.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jbiomech.2007.12.008","pdf_url":null,"source":{"id":"https://openalex.org/S181675524","display_name":"Journal of Biomechanics","issn_l":"0021-9290","issn":["0021-9290","1873-2380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101808427","display_name":"Jie Wu","orcid":"https://orcid.org/0000-0003-4245-875X","observed_orcids":["https://orcid.org/0000-0003-4245-875X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Wu","raw_affiliation_strings":["Department of Mechanics and Engineering Science, Fudan University, Handan Road 220, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanics and Engineering Science, Fudan University, Handan Road 220, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103446380","display_name":"Shixiong Xu","orcid":"https://orcid.org/0009-0007-1818-7773","observed_orcids":["https://orcid.org/0009-0007-1818-7773"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shixiong Xu","raw_affiliation_strings":["Department of Mechanics and Engineering Science, Fudan University, Handan Road 220, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanics and Engineering Science, Fudan University, Handan Road 220, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013709160","display_name":"Quan Long","orcid":"https://orcid.org/0000-0002-9631-1457","observed_orcids":["https://orcid.org/0000-0002-9631-1457"]},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Quan Long","raw_affiliation_strings":["Brunel Institute for Bioengineering, School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UK","Brunel Institute for Bioengineering,School of Engineering and Design,Brunel University,Uxbridge,Middlesex,UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brunel Institute for Bioengineering, School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UK","institution_ids":["https://openalex.org/I59433898"]},{"raw_affiliation_string":"Brunel Institute for Bioengineering,School of Engineering and Design,Brunel University,Uxbridge,Middlesex,UK)","institution_ids":["https://openalex.org/I59433898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016797957","display_name":"Michael W. Collins","orcid":"https://orcid.org/0000-0002-9937-1447","observed_orcids":["https://orcid.org/0000-0002-9937-1447"]},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael W. Collins","raw_affiliation_strings":["Brunel Institute for Bioengineering, School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UK","Brunel Institute for Bioengineering,School of Engineering and Design,Brunel University,Uxbridge,Middlesex,UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brunel Institute for Bioengineering, School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UK","institution_ids":["https://openalex.org/I59433898"]},{"raw_affiliation_string":"Brunel Institute for Bioengineering,School of Engineering and Design,Brunel University,Uxbridge,Middlesex,UK)","institution_ids":["https://openalex.org/I59433898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013434015","display_name":"Carola S. K\u00f6nig","orcid":"https://orcid.org/0000-0002-9289-3154","observed_orcids":["https://orcid.org/0000-0002-9289-3154"]},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carola S. K\u00f6nig","raw_affiliation_strings":["Brunel Institute for Bioengineering, School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UK","Brunel Institute for Bioengineering,School of Engineering and Design,Brunel University,Uxbridge,Middlesex,UK)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brunel Institute for Bioengineering, School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UK","institution_ids":["https://openalex.org/I59433898"]},{"raw_affiliation_string":"Brunel Institute for Bioengineering,School of Engineering and Design,Brunel University,Uxbridge,Middlesex,UK)","institution_ids":["https://openalex.org/I59433898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068301262","display_name":"Gaiping Zhao","orcid":"https://orcid.org/0009-0006-5676-2284","observed_orcids":["https://orcid.org/0009-0006-5676-2284"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaiping Zhao","raw_affiliation_strings":["Department of Mechanics and Engineering Science, Fudan University, Handan Road 220, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanics and Engineering Science, Fudan University, Handan Road 220, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102716965","display_name":"Yuping Jiang","orcid":"https://orcid.org/0000-0003-2538-973X","observed_orcids":["https://orcid.org/0000-0003-2538-973X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159575","display_name":"Huashan Hospital","ror":"https://ror.org/05201qm87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuping Jiang","raw_affiliation_strings":["Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","Department of neurology, Huashan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]},{"raw_affiliation_string":"Department of neurology, Huashan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043512230","display_name":"Anwar R. Padhani","orcid":"https://orcid.org/0000-0002-5830-5777","observed_orcids":["https://orcid.org/0000-0002-5830-5777"]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anwar R. Padhani","raw_affiliation_strings":["Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, UK","institution_ids":["https://openalex.org/I2801038905"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103446380"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":3.2525,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90617284,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"41","issue":"5","first_page":"996","last_page":"1004"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microcirculation","display_name":"tumor microcirculation","score":0.996999979019165},{"id":"https://openalex.org/keywords/interstitial-fluid-flow","display_name":"interstitial fluid flow","score":0.9039999842643738},{"id":"https://openalex.org/keywords/vascular-leakage","display_name":"vascular leakage","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/microvascular-networks","display_name":"microvascular networks","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hemorheology","display_name":"hemorheology","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hematocrit-distribution","display_name":"hematocrit distribution","score":0.925000011920929},{"id":"https://openalex.org/keywords/vessel-compliance","display_name":"vessel compliance","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5009999871253967},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.7637516260147095},{"id":"https://openalex.org/C150489694","wikidata":"https://www.wikidata.org/wiki/Q6057172","display_name":"Interstitial space","level":2,"score":0.7585057020187378},{"id":"https://openalex.org/C2779822359","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Interstitial fluid","level":2,"score":0.5824272632598877},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5218114852905273},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5200412273406982},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.45081645250320435},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38165226578712463},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3678819537162781},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3328809440135956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2039477527141571},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12105491757392883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.087647944688797}],"mesh":[{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jbiomech.2007.12.008","doi":"https://doi.org/10.1016/j.jbiomech.2007.12.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jbiomech.2007.12.008","pdf_url":null,"source":{"id":"https://openalex.org/S181675524","display_name":"Journal of Biomechanics","issn_l":"0021-9290","issn":["0021-9290","1873-2380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanics","raw_type":"journal-article"},{"id":"pmid:18222455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18222455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomechanics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5182945866","display_name":"\u80bf\u7624\u8840\u6db2\u52a8\u529b\u5b66\u548c\u836f\u7269\u4f20\u9012","funder_award_id":"10372026","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8050254941","display_name":null,"funder_award_id":"2007100861","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W655106915","https://openalex.org/W1502576854","https://openalex.org/W1504011557","https://openalex.org/W1651729475","https://openalex.org/W1751852575","https://openalex.org/W1966445054","https://openalex.org/W1978550123","https://openalex.org/W2007924064","https://openalex.org/W2008718474","https://openalex.org/W2030653490","https://openalex.org/W2048195900","https://openalex.org/W2064701790","https://openalex.org/W2066374954","https://openalex.org/W2066724170","https://openalex.org/W2086356330","https://openalex.org/W2104888958","https://openalex.org/W2104903940","https://openalex.org/W2122913894","https://openalex.org/W2126410943","https://openalex.org/W2164522304","https://openalex.org/W2170952917","https://openalex.org/W2371056779","https://openalex.org/W2506145790","https://openalex.org/W2521157257","https://openalex.org/W6630228406"],"related_works":["https://openalex.org/W1984310646","https://openalex.org/W2031047412","https://openalex.org/W2075884354","https://openalex.org/W2358670732","https://openalex.org/W1095729226","https://openalex.org/W2986898479","https://openalex.org/W404125903","https://openalex.org/W1843966557","https://openalex.org/W1485124972","https://openalex.org/W2385327185"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
