{"id":"https://openalex.org/W205226821","doi":null,"title":"[Granulocyte colony-stimulating factor in the newborn neutropenic patient].","display_name":"[Granulocyte colony-stimulating factor in the newborn neutropenic patient].","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W205226821","mag":"205226821","pmid":"https://pubmed.ncbi.nlm.nih.gov/9972625"},"language":"es","primary_location":{"id":"pmid:9972625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9972625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales espanoles de pediatria","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041329565","display_name":"F\u00e9lix Castillo Salinas","orcid":"https://orcid.org/0000-0003-3155-6290","observed_orcids":["https://orcid.org/0000-0003-3155-6290"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F Castillo Salinas","raw_affiliation_strings":["Servicio de Neonatolog\u00eda, Hospital Universitario Materno-Infantil Valle Hebr\u00f3n, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Neonatolog\u00eda, Hospital Universitario Materno-Infantil Valle Hebr\u00f3n, Barcelona","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058907877","display_name":"Cristina D\u00edaz de Heredia","orcid":"https://orcid.org/0000-0001-8086-296X","observed_orcids":["https://orcid.org/0000-0001-8086-296X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C D\u00edaz de Heredia Rubio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069370895","display_name":"Salvador Salcedo","orcid":"https://orcid.org/0009-0006-4606-2639","observed_orcids":["https://orcid.org/0009-0006-4606-2639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Salcedo Abizanda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071420174","display_name":"A Ferrer Comalat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Ferrer Comalat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Bastida Vila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Bastida Vila","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113717146","display_name":"J.J. Ortega Aramburu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Ortega Aramburu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074110505","display_name":"G. Peguero Monforte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Peguero Monforte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"6","first_page":"615","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.4487000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":1.0},{"id":"https://openalex.org/keywords/neonatal-neutropenia","display_name":"neonatal neutropenia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.7009999752044678},{"id":"https://openalex.org/keywords/neonatal-sepsis","display_name":"neonatal sepsis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bone-marrow-aspirate","display_name":"bone marrow aspirate","score":0.8539999723434448},{"id":"https://openalex.org/keywords/sepsis-prevention","display_name":"sepsis prevention","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7039373517036438},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7026898860931396}],"mesh":[{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9972625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9972625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales espanoles de pediatria","raw_type":"Clinical Trial"},{"id":"mag:205226821","doi":null,"is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/articulo?codigo=4412443","pdf_url":null,"source":{"id":"https://openalex.org/S136590224","display_name":"Anales de Pediatr\u00eda","issn_l":"1695-4033","issn":["1695-4033","1695-9531"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Anales de Pediatr\u00eda","raw_type":null},{"id":"mag:2474015508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9972625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2474015508","https://openalex.org/W4229805647","https://openalex.org/W2582314275","https://openalex.org/W2085616231","https://openalex.org/W3036049806","https://openalex.org/W2025821897","https://openalex.org/W1983519463","https://openalex.org/W4385789753","https://openalex.org/W3018335416","https://openalex.org/W2122555521"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,32,120,135,142],"therapeutic":[4],"effect":[5],"of":[6,16,43,56,122,139],"G-CSF":[7,34,85,101,106,133],"in":[8,24,31,63,69,111,115,119,134,141],"newborns":[9],"with":[10,14,117],"neutropenia.":[11],"METHODS:":[12],"Newborn":[13],"evidence":[15],"both":[17],"peripheral":[18,74,112],"neutropenia":[19],"and":[20,66,137],"decreased":[21],"granulocytic":[22],"precursors":[23],"tibial":[25],"bone":[26],"marrow":[27],"aspirate":[28],"were":[29,50,103],"included":[30],"study.":[33],"was":[35,87],"perfused":[36],"intravenously":[37],"over":[38],"2":[39],"hours":[40],"at":[41],"dose":[42,55],"10":[44],"micrograms/kg/day,":[45],"during":[46],"4-8":[47],"days.":[48],"CBC":[49],"obtained":[51],"immediately":[52],"before":[53],"each":[54],"G-CSF.":[57],"RESULTS:":[58],"Neutropenia":[59],"followed":[60],"neonatal":[61],"sepsis":[62,140],"four":[64],"cases":[65],"maternal":[67],"pre-eclampsia":[68],"three.":[70],"Prior":[71],"to":[72,82,91,100],"treatment,":[73],"blood":[75],"granulocyte":[76],"(PMNL)":[77],"counts":[78,89,114],"ranged":[79],"from":[80],"420":[81],"1,073/mm3.":[83],"Once":[84],"infusion":[86],"started,":[88],"returned":[90],"normal":[92],"within":[93],"24-48":[94],"hours.":[95],"No":[96],"adverse":[97],"effects":[98],"related":[99],"administration":[102],"noticed.":[104],"CONCLUSIONS:":[105],"induces":[107],"a":[108,129],"significant":[109,123],"increase":[110],"PMNL":[113],"newborn":[116],"neutropenia,":[118],"absence":[121],"toxic":[124],"effects.":[125],"Our":[126],"date":[127],"suggest":[128],"potential":[130],"role":[131],"for":[132],"prophylaxis":[136],"treatment":[138],"neutropenic":[143],"newborn,":[144],"although":[145],"widespread":[146],"recommendation":[147],"must":[148],"await":[149],"further,":[150],"controlled":[151],"studies.":[152]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}