{"id":"https://openalex.org/W2052267735","doi":"https://doi.org/10.1371/journal.pone.0033475","title":"Differential Expression of Vegfr-2 and Its Soluble Form in Preeclampsia","display_name":"Differential Expression of Vegfr-2 and Its Soluble Form in Preeclampsia","publication_year":2012,"publication_date":"2012-03-12","ids":{"openalex":"https://openalex.org/W2052267735","doi":"https://doi.org/10.1371/journal.pone.0033475","mag":"2052267735","pmid":"https://pubmed.ncbi.nlm.nih.gov/22428059","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3299790"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0033475","doi":"https://doi.org/10.1371/journal.pone.0033475","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033475","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033475&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2052267735"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033475&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002651600","display_name":"Carine Munaut","orcid":"https://orcid.org/0000-0003-4952-9637","observed_orcids":["https://orcid.org/0000-0003-4952-9637"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Carine Munaut","raw_affiliation_strings":["Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium. c.munaut@ulg.ac.be","Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium. c.munaut@ulg.ac.be","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]},{"raw_affiliation_string":"Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015604035","display_name":"Sophie Lorquet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210159123","display_name":"Centre hospitalier r\u00e9gional de la Citadelle","ror":"https://ror.org/059kfmf89","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210159123"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sophie Lorquet","raw_affiliation_strings":["Department of Obstetrics and Gynecology, H\u00f4pital la Citadelle, Li\u00e8ge, Belgium","Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, H\u00f4pital la Citadelle, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210159123"]},{"raw_affiliation_string":"Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051690225","display_name":"Christel P\u00e9queux","orcid":"https://orcid.org/0000-0001-8275-1489","observed_orcids":["https://orcid.org/0000-0001-8275-1489"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christel Pequeux","raw_affiliation_strings":["Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065713082","display_name":"C. Coulon","orcid":"https://orcid.org/0000-0002-9457-9564","observed_orcids":["https://orcid.org/0000-0002-9457-9564"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210104040","display_name":"H\u00f4pital Jeanne de Flandre","ror":"https://ror.org/01e8kn913","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210104040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Capucine Coulon","raw_affiliation_strings":["Maternit\u00e9 Jeanne de Flandre, CHRU, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternit\u00e9 Jeanne de Flandre, CHRU, Lille, France","institution_ids":["https://openalex.org/I3018718406","https://openalex.org/I4210104040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034732019","display_name":"Jeanne Le Goarant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210104040","display_name":"H\u00f4pital Jeanne de Flandre","ror":"https://ror.org/01e8kn913","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210104040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jeanne Le Goarant","raw_affiliation_strings":["Maternit\u00e9 Jeanne de Flandre, CHRU, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternit\u00e9 Jeanne de Flandre, CHRU, Lille, France","institution_ids":["https://openalex.org/I3018718406","https://openalex.org/I4210104040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052797735","display_name":"Fr\u00e9d\u00e9ric Chantraine","orcid":"https://orcid.org/0000-0001-9639-7038","observed_orcids":["https://orcid.org/0000-0001-9639-7038"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210159123","display_name":"Centre hospitalier r\u00e9gional de la Citadelle","ror":"https://ror.org/059kfmf89","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210159123"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Chantraine","raw_affiliation_strings":["Department of Obstetrics and Gynecology, H\u00f4pital la Citadelle, Li\u00e8ge, Belgium","Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, H\u00f4pital la Citadelle, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210159123"]},{"raw_affiliation_string":"Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084744120","display_name":"Agn\u00e8s No\u00ebl","orcid":"https://orcid.org/0000-0002-7670-6179","observed_orcids":["https://orcid.org/0000-0002-7670-6179"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Agn\u00e8s No\u00ebl","raw_affiliation_strings":["Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015368054","display_name":"Fr\u00e9d\u00e9ric Goffin","orcid":"https://orcid.org/0000-0001-9327-9204","observed_orcids":["https://orcid.org/0000-0001-9327-9204","https://orcid.org/0009-0007-6934-1881"]},"institutions":[{"id":"https://openalex.org/I4210159123","display_name":"Centre hospitalier r\u00e9gional de la Citadelle","ror":"https://ror.org/059kfmf89","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210159123"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Goffin","raw_affiliation_strings":["Department of Obstetrics and Gynecology, H\u00f4pital la Citadelle, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, H\u00f4pital la Citadelle, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210159123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029642865","display_name":"Vassilis Tsatsaris","orcid":"https://orcid.org/0000-0002-7650-6660","observed_orcids":["https://orcid.org/0000-0002-7650-6660"]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210097533","display_name":"Maternit\u00e9 Port Royal","ror":"https://ror.org/00x72gm71","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097533"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vassilis Tsatsaris","raw_affiliation_strings":["Maternit\u00e9 Port-Royal, H\u00f4pital Cochin\u2013Saint-Vincent-de-Paul, AP-HP, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternit\u00e9 Port-Royal, H\u00f4pital Cochin\u2013Saint-Vincent-de-Paul, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210097533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107893355","display_name":"Damien Subtil","orcid":"https://orcid.org/0000-0002-7049-4566","observed_orcids":["https://orcid.org/0000-0002-7049-4566"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210104040","display_name":"H\u00f4pital Jeanne de Flandre","ror":"https://ror.org/01e8kn913","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210104040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Damien Subtil","raw_affiliation_strings":["Maternit\u00e9 Jeanne de Flandre, CHRU, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternit\u00e9 Jeanne de Flandre, CHRU, Lille, France","institution_ids":["https://openalex.org/I3018718406","https://openalex.org/I4210104040"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062387212","display_name":"Jean\u2010Michel Foidart","orcid":"https://orcid.org/0000-0001-8285-3573","observed_orcids":["https://orcid.org/0000-0001-8285-3573"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210159123","display_name":"Centre hospitalier r\u00e9gional de la Citadelle","ror":"https://ror.org/059kfmf89","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210159123"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean-Michel Foidart","raw_affiliation_strings":["Department of Obstetrics and Gynecology, H\u00f4pital la Citadelle, Li\u00e8ge, Belgium","Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, H\u00f4pital la Citadelle, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210159123"]},{"raw_affiliation_string":"Laboratory of Tumor and Development Biology, CHU, GIGA-Cancer, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5002651600"],"corresponding_institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.717,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93709377,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"3","first_page":"e33475","last_page":"e33475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":1.0},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.9409999847412109},{"id":"https://openalex.org/keywords/soluble-fms-like-tyrosine-kinase-1","display_name":"soluble fms-like tyrosine kinase-1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/soluble-endoglin","display_name":"soluble endoglin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/antiangiogenic-factors","display_name":"anti-angiogenic factors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.9279999732971191},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8019999861717224},{"id":"https://openalex.org/keywords/postpartum-period","display_name":"postpartum period","score":0.5099999904632568},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5059999823570251},{"id":"https://openalex.org/keywords/lymphangiogenesis","display_name":"lymphangiogenesis","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.7316851019859314},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.5879555940628052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5608460903167725},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.5283154845237732},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5240278840065002},{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.5080544948577881},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.49006330966949463},{"id":"https://openalex.org/C3017575891","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma levels","level":2,"score":0.47717443108558655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43813854455947876},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41749921441078186},{"id":"https://openalex.org/C2776871010","wikidata":"https://www.wikidata.org/wiki/Q18030500","display_name":"Placental growth factor","level":4,"score":0.41363397240638733},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.41260504722595215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38052648305892944},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3378174901008606},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.31169238686561584},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2678242325782776},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.23372143507003784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17494440078735352},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16348257660865784},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.16084390878677368},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.1096470057964325},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09168136119842529},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.07533922791481018},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071063","descriptor_name":"Endoglin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005602","descriptor_name":"France","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040281","descriptor_name":"Vascular Endothelial Growth Factor Receptor-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0033475","doi":"https://doi.org/10.1371/journal.pone.0033475","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033475","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033475&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:22428059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22428059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3299790","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3299790/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/124720","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/124720","pdf_url":"https://orbi.uliege.be/bitstream/2268/124720/1/Munaut%20C%20Plos%20one%202012.pdf","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 7 (3), e33475 (2012-03)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.271.2955","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.271.2955","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a5/c4/PLoS_One_2012_Mar_12_7(3)_e33475.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d07771b927044f0fb97b94e77484769b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d07771b927044f0fb97b94e77484769b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e33475 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0033475","doi":"https://doi.org/10.1371/journal.pone.0033475","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033475","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033475&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052267735.pdf","grobid_xml":"https://content.openalex.org/works/W2052267735.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1502896205","https://openalex.org/W1973918329","https://openalex.org/W1983186128","https://openalex.org/W1983388032","https://openalex.org/W1985043086","https://openalex.org/W1992740425","https://openalex.org/W2002730408","https://openalex.org/W2005748070","https://openalex.org/W2017904618","https://openalex.org/W2030764821","https://openalex.org/W2034797581","https://openalex.org/W2037626596","https://openalex.org/W2040089666","https://openalex.org/W2041999129","https://openalex.org/W2042086323","https://openalex.org/W2053976090","https://openalex.org/W2057531505","https://openalex.org/W2068629155","https://openalex.org/W2075694732","https://openalex.org/W2091774189","https://openalex.org/W2101410165","https://openalex.org/W2102881826","https://openalex.org/W2105632053","https://openalex.org/W2116806083","https://openalex.org/W2119084006","https://openalex.org/W2129158647","https://openalex.org/W2129206669","https://openalex.org/W2134473118","https://openalex.org/W2137974862","https://openalex.org/W2142551707","https://openalex.org/W2143180984","https://openalex.org/W2149962573","https://openalex.org/W2166156136","https://openalex.org/W2168250718","https://openalex.org/W2169958477","https://openalex.org/W4211054086","https://openalex.org/W4236182870","https://openalex.org/W4244433662","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2002730408","https://openalex.org/W2955618051","https://openalex.org/W2160962743","https://openalex.org/W1484751511","https://openalex.org/W2142935918","https://openalex.org/W2101410165","https://openalex.org/W2399375425","https://openalex.org/W2028131307","https://openalex.org/W2070525486"],"abstract_inverted_index":{"BACKGROUND:":[0],"Several":[1],"studies":[2],"have":[3],"suggested":[4],"that":[5,70,108,168,210,233],"the":[6,66,73,79,87,109,125,137,149,160,169,181,207,226,234,263,266],"main":[7],"features":[8],"of":[9,14,54,63,68,76,81,90,152,172,183,191,237,262,265,272,279,295],"preeclampsia":[10],"(PE)":[11],"are":[12],"consequences":[13],"endothelial":[15,277,296],"dysfunction":[16],"related":[17],"to":[18,38,85,96,258],"excess":[19],"circulating":[20,270],"anti-angiogenic":[21,238],"factors,":[22,239],"most":[23],"notably,":[24],"soluble":[25,32,42],"sVEGFR-1":[26,174],"(also":[27],"known":[28],"as":[29,35,37,50,194,196,292],"sFlt-1)":[30],"and":[31,95,127,154,175,242],"endoglin":[33],"(sEng),":[34],"well":[36,195],"decreased":[39,156,283],"PlGF.":[40],"Recently,":[41],"VEGF":[43],"type":[44],"2":[45],"receptor":[46],"(sVEGFR-2)":[47],"has":[48],"emerged":[49],"a":[51,61,211,260,275,293],"crucial":[52],"regulator":[53],"lymphangiogenesis.":[55],"To":[56],"date,":[57],"however,":[58],"there":[59],"is":[60],"paucity":[62],"information":[64],"on":[65],"changes":[67],"VEGFR-2":[69,91,98,110,155,192,216,273,284],"occur":[71],"during":[72,115,159],"clinical":[74],"onset":[75],"PE.":[77,187],"Therefore,":[78],"aim":[80],"our":[82],"study":[83],"was":[84,219],"characterize":[86],"plasma":[88,111,129,150,235,254,285],"levels":[89,112,130,139,151,171,190,224,236,256,271,286],"in":[92,100,136,180,201,225,245,253,287],"PE":[93,116],"patients":[94],"perform":[97],"immunolocalization":[99],"placenta.":[101,267],"METHODOLOGY/PRINCIPAL":[102],"FINDINGS:":[103],"By":[104],"ELISA,":[105],"we":[106],"observed":[107],"were":[113,131,178,199],"reduced":[114],"compared":[117],"with":[118,185],"normal":[119],"gestational":[120],"age":[121],"matched":[122],"pregnancies,":[123],"whereas":[124],"VEGFR-1":[126,138,241,255],"Eng":[128,153,176],"increased.":[132],"The":[133,188,250,268,282],"dramatic":[134],"drop":[135],"shortly":[140],"after":[141,248],"delivery":[142,264],"confirmed":[143],"its":[144],"placental":[145],"origin.":[146],"In":[147],"contrast,":[148],"only":[157],"moderately":[158],"early":[161],"postpartum":[162],"period.":[163],"An":[164],"RT-PCR":[165],"analysis":[166],"showed":[167],"relative":[170,189,223],"VEGFR-1,":[173],"mRNA":[177,193,217],"increased":[179],"placentas":[182],"women":[184,289],"severe":[186],"expressing":[197],"cells,":[198],"similar":[200],"both":[202],"groups.":[203],"We":[204],"also":[205],"made":[206],"novel":[208],"finding":[209],"recently":[212],"described":[213],"alternatively":[214],"spliced":[215],"variant":[218],"present":[220],"at":[221],"lower":[222],"preeclamptic":[227,288],"placentas.":[228],"CONCLUSIONS/SIGNIFICANCE:":[229],"Our":[230],"results":[231],"indicate":[232],"particularly":[240],"VEGFR-2,":[243],"behave":[244],"different":[246],"ways":[247],"delivery.":[249],"rapid":[251],"decrease":[252],"appears":[257],"be":[259],"consequence":[261],"persistent":[269],"suggest":[274],"maternal":[276],"origin":[278],"this":[280],"peptide.":[281],"may":[290],"serve":[291],"marker":[294],"dysfunction.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
