{"id":"https://openalex.org/W2052257207","doi":"https://doi.org/10.1371/journal.pone.0112831","title":"Primary Murine CD4+ T Cells Fail to Acquire the Ability to Produce Effector Cytokines When Active Ras Is Present during Th1/Th2 Differentiation","display_name":"Primary Murine CD4+ T Cells Fail to Acquire the Ability to Produce Effector Cytokines When Active Ras Is Present during Th1/Th2 Differentiation","publication_year":2014,"publication_date":"2014-11-14","ids":{"openalex":"https://openalex.org/W2052257207","doi":"https://doi.org/10.1371/journal.pone.0112831","mag":"2052257207","pmid":"https://pubmed.ncbi.nlm.nih.gov/25397617"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0112831","doi":"https://doi.org/10.1371/journal.pone.0112831","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112831","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112831&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112831&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015968071","display_name":"Sujit V. Janardhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujit V. Janardhan","raw_affiliation_strings":["Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107562083","display_name":"Reinhard Marks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reinhard Marks","raw_affiliation_strings":["Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085317448","display_name":"Thomas Frank Gajewski","orcid":"https://orcid.org/0000-0001-5727-3972","observed_orcids":["https://orcid.org/0000-0001-5727-3972"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas F. Gajewski","raw_affiliation_strings":["Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America; Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America","Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America","Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America; Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Pathology, The University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085317448"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.10559821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"11","first_page":"e112831","last_page":"e112831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/th1-th2-differentiation","display_name":"Th1/Th2 differentiation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.890999972820282},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.8510000109672546},{"id":"https://openalex.org/keywords/stat4","display_name":"STAT4","score":0.7020000219345093},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-bet","display_name":"T-bet","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gata3","display_name":"GATA3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.828000009059906},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9629999995231628},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6533735990524292},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6452168226242065},{"id":"https://openalex.org/C65439459","wikidata":"https://www.wikidata.org/wiki/Q14914618","display_name":"STAT4","level":5,"score":0.5862642526626587},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5407995581626892},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.5300295948982239},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49071037769317627},{"id":"https://openalex.org/C120642132","wikidata":"https://www.wikidata.org/wiki/Q14907110","display_name":"ZAP70","level":5,"score":0.46924781799316406},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.45607808232307434},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.45364710688591003},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44202178716659546},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.4303813576698303},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4197740852832794},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4016614556312561},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39530128240585327},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3561999499797821},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2612183094024658},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.12941068410873413},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10254725813865662},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062727","descriptor_name":"Coxsackie and Adenovirus Receptor-Like Membrane Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062727","descriptor_name":"Coxsackie and Adenovirus Receptor-Like Membrane Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062727","descriptor_name":"Coxsackie and Adenovirus Receptor-Like Membrane Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0112831","doi":"https://doi.org/10.1371/journal.pone.0112831","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112831","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112831&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:25397617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25397617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4232516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4232516","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.4349","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.4349","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a6/60/pone.0112831.PMC4232516.pdf","raw_type":"text"},{"id":"pmh:oai:uchicago.tind.io:10549","doi":null,"is_oa":true,"landing_page_url":"http://knowledge.uchicago.edu/record/10549","pdf_url":null,"source":{"id":"https://openalex.org/S4306402460","display_name":"Knowledge@UChicago (University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40347166","host_organization_name":"University of Chicago","host_organization_lineage":["https://openalex.org/I40347166"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://knowledge.uchicago.edu/record/10549","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3a2a62deedee4159b4bd417362f15adb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3a2a62deedee4159b4bd417362f15adb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 11, p e112831 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1241839","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Primary_Murine_CD4_T_Cells_Fail_to_Acquire_the_Ability_to_Produce_Effector_Cytokines_When_Active_Ras_Is_Present_during_Th1_Th2_Differentiation/1241839","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6082/5aa62-35w29","doi":"https://doi.org/10.6082/5aa62-35w29","is_oa":true,"landing_page_url":"https://doi.org/10.6082/5aa62-35w29","pdf_url":null,"source":{"id":"https://openalex.org/S7407053018","display_name":"University of Chicago","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6082/sr5h2-je327","doi":"https://doi.org/10.6082/sr5h2-je327","is_oa":true,"landing_page_url":"https://doi.org/10.6082/sr5h2-je327","pdf_url":null,"source":{"id":"https://openalex.org/S7407053018","display_name":"University of Chicago","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0112831","doi":"https://doi.org/10.1371/journal.pone.0112831","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112831","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112831&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1873961559","display_name":null,"funder_award_id":"R01 CA118153","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2862788858","display_name":null,"funder_award_id":"R21 AI059818","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4139430459","display_name":null,"funder_award_id":"R21AI59818","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G898378059","display_name":null,"funder_award_id":"UL1 TR000430","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052257207.pdf","grobid_xml":"https://content.openalex.org/works/W2052257207.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1504215273","https://openalex.org/W1522861336","https://openalex.org/W1544291870","https://openalex.org/W1788605047","https://openalex.org/W1915573821","https://openalex.org/W1967261754","https://openalex.org/W1987589866","https://openalex.org/W1995872633","https://openalex.org/W1996294295","https://openalex.org/W1997283150","https://openalex.org/W2004032966","https://openalex.org/W2008261028","https://openalex.org/W2008844540","https://openalex.org/W2011386690","https://openalex.org/W2012964934","https://openalex.org/W2015069573","https://openalex.org/W2020096790","https://openalex.org/W2022447132","https://openalex.org/W2022680308","https://openalex.org/W2027359667","https://openalex.org/W2027699993","https://openalex.org/W2029149519","https://openalex.org/W2029860358","https://openalex.org/W2031513892","https://openalex.org/W2031967183","https://openalex.org/W2037061225","https://openalex.org/W2045500858","https://openalex.org/W2052371969","https://openalex.org/W2055825597","https://openalex.org/W2059810240","https://openalex.org/W2063950156","https://openalex.org/W2066331485","https://openalex.org/W2070210483","https://openalex.org/W2075517727","https://openalex.org/W2078459253","https://openalex.org/W2080484121","https://openalex.org/W2082610530","https://openalex.org/W2086368962","https://openalex.org/W2090831287","https://openalex.org/W2091301099","https://openalex.org/W2092263607","https://openalex.org/W2093902610","https://openalex.org/W2101548741","https://openalex.org/W2107243002","https://openalex.org/W2107351229","https://openalex.org/W2112001206","https://openalex.org/W2116399340","https://openalex.org/W2122659156","https://openalex.org/W2134202806","https://openalex.org/W2148013423","https://openalex.org/W2153683741","https://openalex.org/W2595452534","https://openalex.org/W2886978647","https://openalex.org/W4239155095","https://openalex.org/W4241210960"],"related_works":["https://openalex.org/W2104899797","https://openalex.org/W2072502005","https://openalex.org/W1534159754","https://openalex.org/W2002809032","https://openalex.org/W4235353359","https://openalex.org/W1515040786","https://openalex.org/W2126519126","https://openalex.org/W2099633403","https://openalex.org/W2075052419","https://openalex.org/W2344342494"],"abstract_inverted_index":{"Constitutive":[0],"Ras":[1,33,64,88,113,190,222],"signaling":[2,191,224],"has":[3],"been":[4],"shown":[5],"to":[6,107,121,136,199,220,240],"augment":[7],"IL-2":[8,90],"production,":[9],"reverse":[10],"anergy,":[11],"and":[12,156],"functionally":[13],"replace":[14],"many":[15],"aspects":[16],"of":[17,31,46,62,117,154,172,185,195,214],"CD28":[18],"co-stimulation":[19],"in":[20,40,43,65,92,163,207,225,228,244],"CD4+":[21,69,94,118,196],"T":[22,36,47,67,70,95,119,187,197,226],"cells.":[23,96],"These":[24],"data":[25],"raise":[26],"the":[27,59,115,173,193],"possibility":[28],"that":[29],"introduction":[30],"active":[32,63,83,87,112,164],"into":[34,202],"primary":[35,66],"cells":[37,71,99,120,166,198,227],"might":[38],"result":[39],"improved":[41],"functionality":[42],"pathologic":[44],"situations":[45],"cell":[48,110],"dysfunction,":[49],"such":[50],"as":[51,236],"cancer":[52],"or":[53,125,139,144],"chronic":[54],"viral":[55],"infection.":[56],"To":[57],"test":[58],"biologic":[60],"effects":[61],"cells,":[68,188,206],"from":[72],"Coxsackie-Adenovirus":[73],"Receptor":[74],"Transgenic":[75],"mice":[76],"were":[77,100],"transduced":[78],"with":[79,151,169,211],"an":[80],"adenovirus":[81],"encoding":[82],"Ras.":[84],"As":[85],"expected,":[86],"augmented":[89],"production":[91,162],"naive":[93],"However,":[97],"when":[98],"cultured":[101],"for":[102],"4":[103],"days":[104],"under":[105],"conditions":[106],"promote":[108],"effector":[109,127,160,204,215],"differentiation,":[111],"inhibited":[114],"ability":[116,194],"acquire":[122],"a":[123,229,237],"Th1":[124],"Th2":[126],"cytokine":[128,161],"profile.":[129],"This":[130],"differentiation":[131],"defect":[132],"was":[133,148,167],"not":[134],"due":[135],"deficient":[137,152,170],"STAT4":[138],"STAT6":[140],"activation":[141,184],"by":[142,209],"IL-12":[143],"IL-4,":[145],"respectively,":[146],"nor":[147],"it":[149],"associated":[150,168],"induction":[153],"T-bet":[155],"GATA-3":[157],"expression.":[158],"Impaired":[159],"Ras-transduced":[165],"demethylation":[171],"IL-4":[174],"gene":[175,216],"locus.":[176],"Our":[177],"results":[178],"indicate":[179],"that,":[180],"despite":[181],"augmenting":[182],"acute":[183],"na\u00efve":[186],"constitutive":[189],"inhibits":[192],"properly":[200],"differentiate":[201],"Th1/Th2":[203],"cytokine-producing":[205],"part":[208],"interfering":[210],"epigenetic":[212],"modification":[213],"loci.":[217],"Alternative":[218],"strategies":[219],"potentiate":[221],"pathway":[223],"more":[230],"regulated":[231],"fashion":[232],"should":[233],"be":[234],"considered":[235],"therapeutic":[238],"approach":[239],"improve":[241],"immune":[242],"responses":[243],"vivo.":[245]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}