{"id":"https://openalex.org/W2052228988","doi":"https://doi.org/10.1007/bf00266277","title":"Continuous production of oxytetracycline by immobilized growing Streptomyces rimosus cells","display_name":"Continuous production of oxytetracycline by immobilized growing Streptomyces rimosus cells","publication_year":1986,"publication_date":"1986-04-01","ids":{"openalex":"https://openalex.org/W2052228988","doi":"https://doi.org/10.1007/bf00266277","mag":"2052228988"},"language":"en","primary_location":{"id":"doi:10.1007/bf00266277","doi":"https://doi.org/10.1007/bf00266277","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00266277","pdf_url":null,"source":{"id":"https://openalex.org/S70979998","display_name":"Applied Microbiology and Biotechnology","issn_l":"0175-7598","issn":["0175-7598","1432-0614"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Microbiology and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048928282","display_name":"Mamoru Ogaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Ogaki","raw_affiliation_strings":["Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan","Laboratory of Industrial Biochemistry, Department of Industrial Chemistry,. Faculty of Engineering, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of Industrial Biochemistry, Department of Industrial Chemistry,. Faculty of Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022291195","display_name":"Kenji Sonomoto","orcid":"https://orcid.org/0000-0002-7171-6343","observed_orcids":["https://orcid.org/0000-0002-7171-6343"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Sonomoto","raw_affiliation_strings":["Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan","Laboratory of Industrial Biochemistry, Department of Industrial Chemistry,. Faculty of Engineering, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of Industrial Biochemistry, Department of Industrial Chemistry,. Faculty of Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023958655","display_name":"Hiroki Nakajima","orcid":"https://orcid.org/0000-0003-0518-8156","observed_orcids":["https://orcid.org/0000-0003-0518-8156"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Nakajima","raw_affiliation_strings":["Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan","Laboratory of Industrial Biochemistry, Department of Industrial Chemistry,. Faculty of Engineering, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of Industrial Biochemistry, Department of Industrial Chemistry,. Faculty of Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108369741","display_name":"Atsuo Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuo Tanaka","raw_affiliation_strings":["Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan","Laboratory of Industrial Biochemistry, Department of Industrial Chemistry,. Faculty of Engineering, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Laboratory of Industrial Biochemistry, Department of Industrial Chemistry,. Faculty of Engineering, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":4.7577,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.94976153,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.5414999723434448,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.5414999723434448,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.23720000684261322,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxytetracycline","display_name":"oxytetracycline","score":0.9210000038146973},{"id":"https://openalex.org/keywords/streptomyces-rimosus","display_name":"Streptomyces rimosus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-immobilization","display_name":"cell immobilization","score":0.9179999828338623},{"id":"https://openalex.org/keywords/urethane-prepolymer","display_name":"urethane prepolymer","score":0.8410000205039978},{"id":"https://openalex.org/keywords/polyurethane-gel","display_name":"polyurethane gel","score":0.828000009059906},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.8669999837875366},{"id":"https://openalex.org/keywords/continuous-fermentation","display_name":"continuous fermentation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/glucose-free-medium","display_name":"glucose-free medium","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cell-leakage","display_name":"cell leakage","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antibiotic-production","display_name":"antibiotic production","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2776671240","wikidata":"https://www.wikidata.org/wiki/Q411646","display_name":"Oxytetracycline","level":3,"score":0.927900493144989},{"id":"https://openalex.org/C2779498867","wikidata":"https://www.wikidata.org/wiki/Q2402182","display_name":"Prepolymer","level":3,"score":0.6496237516403198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6388557553291321},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.6162042021751404},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.5411239862442017},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5259371399879456},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3898357152938843},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.20030885934829712},{"id":"https://openalex.org/C2779578285","wikidata":"https://www.wikidata.org/wiki/Q146322","display_name":"Polyurethane","level":2,"score":0.12735027074813843},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09038406610488892}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/bf00266277","doi":"https://doi.org/10.1007/bf00266277","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00266277","pdf_url":null,"source":{"id":"https://openalex.org/S70979998","display_name":"Applied Microbiology and Biotechnology","issn_l":"0175-7598","issn":["0175-7598","1432-0614"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Microbiology and Biotechnology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W142879232","https://openalex.org/W1470126433","https://openalex.org/W1578501396","https://openalex.org/W1637381032","https://openalex.org/W1976932704","https://openalex.org/W1977012634","https://openalex.org/W1980592046","https://openalex.org/W1985729139","https://openalex.org/W2010234574","https://openalex.org/W2013617357","https://openalex.org/W2037210230","https://openalex.org/W2045896989","https://openalex.org/W2049518682","https://openalex.org/W2061612154","https://openalex.org/W2065185619","https://openalex.org/W2077813388","https://openalex.org/W2087963849","https://openalex.org/W2092537787","https://openalex.org/W2098717965","https://openalex.org/W2141957171","https://openalex.org/W2156484224","https://openalex.org/W2158216280","https://openalex.org/W2158854932","https://openalex.org/W2159603802","https://openalex.org/W2314539549"],"related_works":["https://openalex.org/W1549344589","https://openalex.org/W2005765580","https://openalex.org/W2346576044","https://openalex.org/W1972793267","https://openalex.org/W2072941581","https://openalex.org/W2018624989","https://openalex.org/W2011753327","https://openalex.org/W2045896989","https://openalex.org/W2745755481","https://openalex.org/W1967762154"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}