{"id":"https://openalex.org/W2052227078","doi":"https://doi.org/10.1177/0194599814541627a171","title":"Efficacy of L\u2010N\u2010Acetyl Cysteine in the Prevention of Gentamicin Vestibulotoxicity in Rats","display_name":"Efficacy of L\u2010N\u2010Acetyl Cysteine in the Prevention of Gentamicin Vestibulotoxicity in Rats","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W2052227078","doi":"https://doi.org/10.1177/0194599814541627a171","mag":"2052227078"},"language":"en","primary_location":{"id":"doi:10.1177/0194599814541627a171","doi":"https://doi.org/10.1177/0194599814541627a171","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0194599814541627a171","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016744305","display_name":"Venkatakarthikeyan Chokkalingam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Venkatakarthikeyan Chokkalingam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055557790","display_name":"Esperanza Bas","orcid":"https://orcid.org/0000-0002-2359-365X","observed_orcids":["https://orcid.org/0000-0002-2359-365X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esperanza Bas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022198589","display_name":"Stefania Goncalves","orcid":"https://orcid.org/0000-0003-3330-0918","observed_orcids":["https://orcid.org/0000-0003-3330-0918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefania Goncalves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michelle Adams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle Adams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078437564","display_name":"Suhrud M. Rajguru","orcid":"https://orcid.org/0000-0001-5953-8516","observed_orcids":["https://orcid.org/0000-0001-5953-8516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suhrud Rajguru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027146792","display_name":"Thomas R. Van De Water","orcid":"https://orcid.org/0000-0002-5051-9041","observed_orcids":["https://orcid.org/0000-0002-5051-9041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas R. Van De Water","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086980934","display_name":"Simon Ignacio Angeli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon I. Angeli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12526955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"151","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.34060001373291016,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.984000027179718},{"id":"https://openalex.org/keywords/vestibular-toxicity","display_name":"vestibular toxicity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ototoxicity-prevention","display_name":"ototoxicity prevention","score":0.7239999771118164},{"id":"https://openalex.org/keywords/vestibular-evoked-myogenic-potentials","display_name":"vestibular evoked myogenic potentials","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vestibular-hair-cells","display_name":"vestibular hair cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/saccule","display_name":"saccule","score":0.9350000023841858},{"id":"https://openalex.org/keywords/inner-ear-morphology","display_name":"inner ear morphology","score":0.800000011920929},{"id":"https://openalex.org/keywords/intratympanic-administration","display_name":"intratympanic administration","score":0.7580000162124634},{"id":"https://openalex.org/keywords/aminoglycoside-toxicity","display_name":"aminoglycoside toxicity","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2778039178","wikidata":"https://www.wikidata.org/wiki/Q3494094","display_name":"Saccule","level":3,"score":0.9241857528686523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7520349621772766},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6271090507507324},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.5803631544113159},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5575804114341736},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.5529579520225525},{"id":"https://openalex.org/C2776837582","wikidata":"https://www.wikidata.org/wiki/Q7923451","display_name":"Vestibular evoked myogenic potential","level":3,"score":0.5259801745414734},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.43368983268737793},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35954707860946655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35820332169532776},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34646034240722656},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.21317872405052185},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.12799900770187378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11827009916305542},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.11278232932090759},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.10499787330627441},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1177/0194599814541627a171","doi":"https://doi.org/10.1177/0194599814541627a171","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0194599814541627a171","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7128485002","https://openalex.org/W2405368985","https://openalex.org/W1045245205","https://openalex.org/W2339795915","https://openalex.org/W2374004699","https://openalex.org/W2037575079","https://openalex.org/W4283076313","https://openalex.org/W1992310586","https://openalex.org/W2060738674","https://openalex.org/W2072248989"],"abstract_inverted_index":{"Objectives:":[0],"Determine":[1],"the":[2,109,121,142,151,159,183,202],"effect":[3,243],"of":[4,108,182,191,201,220,222,237,244],"L\u2010N\u2010acetylcysteine":[5],"(LNAC)":[6],"on":[7],"gentamicin":[8],"(GM)":[9],"initiated":[10],"vestibulotoxicity.":[11],"Methods:":[12],"Wistar":[13],"rats":[14,192,211,223],"were":[15,86,120,162],"divided":[16],"into":[17],"4":[18],"groups:":[19],"Group":[20],"A":[21],"(n":[22,36,59,76],"=":[23,37,60,77],"7)":[24],"had":[25,39,62,79,196],"intratympanic":[26],"(IT)":[27],"GM":[28,41,55,64,226],"(20":[29],"mg":[30,69],"in":[31,70,124,141,154,180,186,210,228,231,246],"40":[32,71],"\u00b5L);":[33,72],"group":[34,57,74],"B":[35],"6)":[38,61,78],"IT":[40,63,66,81,148,177,218],"and":[42,51,65,73,90,98,102,137,176,217,234,251],"intraperitoneal":[43],"(IP)":[44],"LNAC":[45,67,149,178,195,221,245],"(350":[46],"mg/kg)":[47],"at":[48,99,114,128,171],"24":[49],"hours":[50],"1":[52,100,103,115,172],"hour":[53],"before":[54],"administration;":[56],"C":[58],"(5":[68],"D":[75],"only":[80],"saline":[82],"(40":[83],"\u00b5L).":[84],"Rats":[85,145],"tested":[87],"by":[88],"ABR":[89],"cervical":[91],"vestibular":[92,238],"evoked":[93],"myogenic":[94],"potentials":[95],"(VEMP)":[96],"pretreatment,":[97],"week":[101,173],"month":[104],"posttreatment.":[105,174],"Morphological":[106,199],"analysis":[107,200],"inner":[110],"ears":[111],"was":[112],"performed":[113],"month.":[116],"Main":[117],"outcome":[118],"measures":[119],"mean":[122,155,206],"change":[123,153],"VEMP":[125,156,184,232],"P1":[126],"latency":[127],"sound":[129],"stimulation":[130,170],"from":[131],"80":[132,168],"to":[133],"110":[134],"dB":[135,169],"SPL,":[136],"hair":[138,207,239],"cell":[139,208],"count":[140],"saccule.":[143],"Results:":[144],"treated":[146,224],"with":[147,225],"exhibited":[150],"least":[152],"latencies,":[157],"although":[158],"intergroup":[160],"differences":[161],"not":[163,193,212],"statistically":[164],"significant":[165],"except":[166],"for":[167],"IP":[175],"resulted":[179,227],"preservation":[181,236],"response":[185],"all":[187],"rats,":[188],"whereas":[189],"42%":[190],"receiving":[194,213],"absent":[197],"responses.":[198],"saccule":[203],"revealed":[204],"lower":[205],"counts":[209],"LNAC.":[214],"Conclusions:":[215],"Systemic":[216],"administration":[219],"minimal":[229],"variations":[230],"latencies":[233],"greater":[235],"cells.":[240],"The":[241],"protective":[242],"GM\u2010initiated":[247],"vestibulotoxicity":[248],"is":[249],"promising":[250],"warrants":[252],"further":[253],"research.":[254]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
