{"id":"https://openalex.org/W2052225843","doi":"https://doi.org/10.1074/jbc.m105274200","title":"Mechanisms for Reversible Regulation between G13 and Rho Exchange Factors","display_name":"Mechanisms for Reversible Regulation between G13 and Rho Exchange Factors","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2052225843","doi":"https://doi.org/10.1074/jbc.m105274200","mag":"2052225843","pmid":"https://pubmed.ncbi.nlm.nih.gov/11698392"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m105274200","doi":"https://doi.org/10.1074/jbc.m105274200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m105274200","pdf_url":"http://www.jbc.org/article/S0021925820879095/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820879095/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046419007","display_name":"Clark D. Wells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clark D. Wells","raw_affiliation_strings":["Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041, USA","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109164541","display_name":"Mu-Ya Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mu-Ya Liu","raw_affiliation_strings":["Hybrigen Inc., Dallas, Texas 75207-2307","Hybrigen Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hybrigen Inc., Dallas, Texas 75207-2307","institution_ids":[]},{"raw_affiliation_string":"Hybrigen Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057066783","display_name":"M. T. Jackson","orcid":"https://orcid.org/0000-0002-3374-0086","observed_orcids":["https://orcid.org/0000-0002-3374-0086"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mandy Jackson","raw_affiliation_strings":["Department of Neurology and Neuroscience, Johns Hopkins University, Baltimore, Maryland 21287","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Johns Hopkins University, Baltimore, Maryland 21287","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018298625","display_name":"Stephen Gutowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Gutowski","raw_affiliation_strings":["Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090915378","display_name":"Pamela M. Sternweis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pamela M. Sternweis","raw_affiliation_strings":["Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pamela M. Sternweis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela M. Sternweis","raw_affiliation_strings":["Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","Hybrigen Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Hybrigen Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045098375","display_name":"Jeffrey D. Rothstein","orcid":"https://orcid.org/0000-0003-2001-8470","observed_orcids":["https://orcid.org/0000-0003-2001-8470"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Rothstein","raw_affiliation_strings":["Department of Neurology and Neuroscience, Johns Hopkins University, Baltimore, Maryland 21287","Johns Hopkins University","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Johns Hopkins University, Baltimore, Maryland 21287","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083797018","display_name":"Tohru Kozasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tohru Kozasa","raw_affiliation_strings":["Department of Pharmacology and the Department of Anatomy and Cell Biology, University of Illinois, Chicago, Illinois 60612","Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and the Department of Anatomy and Cell Biology, University of Illinois, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001377302","display_name":"Paul C. Sternweis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul C. Sternweis","raw_affiliation_strings":["Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001377302","display_name":"Paul C. Sternweis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul C. Sternweis","raw_affiliation_strings":["Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001377302","https://openalex.org/A5090915378"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.9681,"has_fulltext":true,"cited_by_count":120,"citation_normalized_percentile":{"value":0.96309238,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"277","issue":"2","first_page":"1174","last_page":"1181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.6949999928474426},{"id":"https://openalex.org/keywords/galpha13","display_name":"G\u03b113","score":0.7570000290870667},{"id":"https://openalex.org/keywords/galpha12","display_name":"G\u03b112","score":0.7450000047683716},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dbl-homology-domain","display_name":"Dbl homology domain","score":0.8059999942779541},{"id":"https://openalex.org/keywords/ph-domain","display_name":"pleckstrin homology domain","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heterotrimeric-g-proteins","display_name":"heterotrimeric G proteins","score":0.8610000014305115},{"id":"https://openalex.org/keywords/rho-gtpase-signaling","display_name":"Rho GTPase signaling","score":0.5709999799728394},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.9069546461105347},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.863117516040802},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.8431648015975952},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.8126558661460876},{"id":"https://openalex.org/C49658373","wikidata":"https://www.wikidata.org/wiki/Q24776397","display_name":"Pleckstrin homology domain","level":3,"score":0.7711458206176758},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.7123175859451294},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.583096444606781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.574320375919342},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5108029842376709},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.5016992092132568},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.4914025068283081},{"id":"https://openalex.org/C66135807","wikidata":"https://www.wikidata.org/wiki/Q24726231","display_name":"Gq alpha subunit","level":4,"score":0.48276105523109436},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28704380989074707}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020962","descriptor_name":"Heterotrimeric GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020962","descriptor_name":"Heterotrimeric GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020962","descriptor_name":"Heterotrimeric GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020962","descriptor_name":"Heterotrimeric GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020962","descriptor_name":"Heterotrimeric GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020962","descriptor_name":"Heterotrimeric GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064067","descriptor_name":"Rho Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064067","descriptor_name":"Rho Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064067","descriptor_name":"Rho Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m105274200","doi":"https://doi.org/10.1074/jbc.m105274200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m105274200","pdf_url":"http://www.jbc.org/article/S0021925820879095/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11698392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11698392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m105274200","doi":"https://doi.org/10.1074/jbc.m105274200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m105274200","pdf_url":"http://www.jbc.org/article/S0021925820879095/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1224273964","display_name":"Mechanisms of Drug Action and Disposition","funder_award_id":"T32GM007062","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2915134793","display_name":null,"funder_award_id":"GM 31954","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3890485823","display_name":"Regulation of Rho family GTPases by heterotrimeric G proteins","funder_award_id":"R01GM061454","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6840634800","display_name":"Signal Transduction Via Receptors and G Proteins","funder_award_id":"5r01gm031954-32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G89440504","display_name":null,"funder_award_id":"GM61454","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000259311","display_name":null,"funder_award_id":"GM31954","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G976019114","display_name":null,"funder_award_id":"GM07062","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052225843.pdf","grobid_xml":"https://content.openalex.org/works/W2052225843.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W154314917","https://openalex.org/W1522435301","https://openalex.org/W1545026312","https://openalex.org/W1554400373","https://openalex.org/W1574617342","https://openalex.org/W1614895539","https://openalex.org/W1750989123","https://openalex.org/W1953109900","https://openalex.org/W1965307343","https://openalex.org/W1966732663","https://openalex.org/W1968137432","https://openalex.org/W1969714257","https://openalex.org/W1984875632","https://openalex.org/W1991756459","https://openalex.org/W1996223704","https://openalex.org/W2004581292","https://openalex.org/W2009359492","https://openalex.org/W2010957690","https://openalex.org/W2022723700","https://openalex.org/W2029445497","https://openalex.org/W2032187164","https://openalex.org/W2037669016","https://openalex.org/W2038351958","https://openalex.org/W2042030773","https://openalex.org/W2050307742","https://openalex.org/W2064483656","https://openalex.org/W2068486863","https://openalex.org/W2071242185","https://openalex.org/W2073223681","https://openalex.org/W2073999242","https://openalex.org/W2077537799","https://openalex.org/W2080875376","https://openalex.org/W2090636422","https://openalex.org/W2095013577","https://openalex.org/W2110458673","https://openalex.org/W2115464623","https://openalex.org/W2135239798","https://openalex.org/W2144554951","https://openalex.org/W2148310842","https://openalex.org/W2163133008","https://openalex.org/W4248350370"],"related_works":["https://openalex.org/W1997074783","https://openalex.org/W1984910438","https://openalex.org/W2162243747","https://openalex.org/W1614895539","https://openalex.org/W2056698109","https://openalex.org/W338648647","https://openalex.org/W2090760233","https://openalex.org/W2035633569","https://openalex.org/W2016923687","https://openalex.org/W1977493444"],"abstract_inverted_index":{"The":[0,36],"heterotrimeric":[1],"G":[2,10,73],"proteins,":[3],"G(12)":[4],"and":[5,13,42,85,115,135,162,189,248,257],"G(13),":[6],"mediate":[7],"signaling":[8,75],"between":[9],"protein-coupled":[11],"receptors":[12],"the":[14,47,64,69,88,104,120,124,159,171,185,199,211,219,238],"monomeric":[15],"GTPase,":[16],"RhoA.":[17,35],"One":[18],"pathway":[19],"for":[20,34,83,111,235],"this":[21,203],"modulation":[22],"is":[23,44,94],"direct":[24,247],"stimulation":[25],"by":[26,46,141,158,228],"Galpha(13)":[27,43,134,153,175,195,252],"of":[28,39,50,68,72,91,123,137,148,184,202,214,218,223,237,242,251],"p115":[29,51,92,149,224,243],"RhoGEF,":[30,150,225],"an":[31],"exchange":[32,55,139,200,240],"factor":[33,56],"GTPase":[37],"activity":[38,128,140,201,241],"both":[40,112,254],"Galpha(12)":[41],"increased":[45],"N":[48,121,221],"terminus":[49,122,222],"Rho":[52],"guanine":[53],"nucleotide":[54,239],"(GEF).":[57],"This":[58],"region":[59,90,108,213],"has":[60],"weak":[61],"homology":[62,187,191],"to":[63,96,133,152,170,178,253],"RGS":[65,89,173,212,256],"box":[66],"sequence":[67],"classic":[70],"regulators":[71],"protein":[74,125,181],"(RGS),":[76],"which":[77,209],"act":[78],"as":[79],"GTPase-activating":[80],"proteins":[81],"(GAP)":[82],"G(i)":[84],"G(q).":[86],"Here,":[87],"RhoGEF":[93,244],"shown":[95],"be":[97],"distinctly":[98],"different":[99],"in":[100,119,216],"that":[101,245],"sequences":[102],"flanking":[103],"predicted":[105],"\"RGS":[106],"box\"":[107],"are":[109],"required":[110],"stable":[113],"expression":[114],"GAP":[116,127,166],"activity.":[117,167],"Deletions":[118],"eliminate":[126],"but":[129,154],"retain":[130],"substantial":[131],"binding":[132,169],"activation":[136,236],"RhoA":[138],"Galpha(13).":[142,229],"In":[143],"contrast,":[144],"GTRAP48,":[145],"a":[146,179,233],"homolog":[147],"bound":[151,177],"was":[155,226],"not":[156,197],"stimulated":[157],"alpha":[160],"subunit":[161],"had":[163],"very":[164],"poor":[165],"Besides":[168],"N-terminal":[172],"region,":[174],"also":[176],"truncated":[180,204],"consisting":[182],"only":[183],"Dbl":[186],"(DH)":[188],"pleckstrin":[190],"(PH)":[192],"domains.":[193,259],"However,":[194],"did":[196],"stimulate":[198],"protein.":[205],"A":[206],"chimeric":[207],"protein,":[208],"contained":[210],"GTRAP48":[215],"place":[217],"endogenous":[220],"activated":[227],"These":[230],"results":[231],"suggest":[232],"mechanism":[234],"involves":[246],"coordinate":[249],"interaction":[250],"its":[255],"DH":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2025-10-10T00:00:00"}