{"id":"https://openalex.org/W2052219580","doi":"https://doi.org/10.1164/ajrccm/140.1.132","title":"Role of Mucus and Cilia in Nasal Mucociliary Clearance in Healthy Subjects","display_name":"Role of Mucus and Cilia in Nasal Mucociliary Clearance in Healthy Subjects","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W2052219580","doi":"https://doi.org/10.1164/ajrccm/140.1.132","mag":"2052219580","pmid":"https://pubmed.ncbi.nlm.nih.gov/2751159"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm/140.1.132","doi":"https://doi.org/10.1164/ajrccm/140.1.132","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/140.1.132","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043116373","display_name":"Huguette A. Liote","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Huguette Liot\u00e9","raw_affiliation_strings":["Centre de Pneumologie et de R\u00e9animation Respiratoire, H\u00f4pital Tenon, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Pneumologie et de R\u00e9animation Respiratoire, H\u00f4pital Tenon, Paris, France","institution_ids":["https://openalex.org/I4210166768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111779809","display_name":"Jean\u2010Marie Zahm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Marie Zahm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110217119","display_name":"Denis Pierrot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denis Pierrot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109283634","display_name":"\u00c9dith Puchelle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edith Puchelle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7928,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.92388122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"140","issue":"1","first_page":"132","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.5659000277519226,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.2583000063896179,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11812","display_name":"Nasal Surgery and Airway Studies","score":0.06700000166893005,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasal-mucociliary-clearance","display_name":"nasal mucociliary clearance","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nasal-mucus","display_name":"nasal mucus","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ciliary-beat-frequency","display_name":"ciliary beat frequency","score":0.8180000185966492},{"id":"https://openalex.org/keywords/saccharin-test","display_name":"saccharin test","score":0.8370000123977661},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7620000243186951},{"id":"https://openalex.org/keywords/intra-individual-variability","display_name":"within-person variability","score":0.8370000123977661},{"id":"https://openalex.org/keywords/environmental-factors","display_name":"environmental factors","score":0.6489999890327454},{"id":"https://openalex.org/keywords/ambient-temperature","display_name":"ambient temperature","score":0.6859999895095825},{"id":"https://openalex.org/keywords/relative-humidity","display_name":"relative humidity","score":0.9539999961853027},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.8040000200271606},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C114682108","wikidata":"https://www.wikidata.org/wiki/Q1952044","display_name":"Mucociliary clearance","level":3,"score":0.9326202273368835},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.8863404989242554},{"id":"https://openalex.org/C2779147919","wikidata":"https://www.wikidata.org/wiki/Q191381","display_name":"Saccharin","level":2,"score":0.5962244868278503},{"id":"https://openalex.org/C18206936","wikidata":"https://www.wikidata.org/wiki/Q378749","display_name":"Clearance rate","level":2,"score":0.534476101398468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4997239112854004},{"id":"https://openalex.org/C59377437","wikidata":"https://www.wikidata.org/wiki/Q515471","display_name":"Mucous membrane of nose","level":2,"score":0.41698580980300903},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.41464143991470337},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3543180823326111},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3110784888267517},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24099239706993103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19151204824447632},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.11621159315109253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009079","descriptor_name":"Mucociliary Clearance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009093","descriptor_name":"Mucus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009299","descriptor_name":"Nasal Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012439","descriptor_name":"Saccharin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm/140.1.132","doi":"https://doi.org/10.1164/ajrccm/140.1.132","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/140.1.132","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},{"id":"pmid:2751159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2751159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W19625469","https://openalex.org/W1788401786","https://openalex.org/W1801276903","https://openalex.org/W1997052614","https://openalex.org/W2005739621","https://openalex.org/W2017927441","https://openalex.org/W2047884381","https://openalex.org/W2066552190","https://openalex.org/W2108344981","https://openalex.org/W2159375637","https://openalex.org/W2266789373","https://openalex.org/W2285608081","https://openalex.org/W2347169036","https://openalex.org/W2401885322"],"related_works":["https://openalex.org/W2047884381","https://openalex.org/W2106271568","https://openalex.org/W2031315720","https://openalex.org/W2013572274","https://openalex.org/W2158228830","https://openalex.org/W7369851","https://openalex.org/W2138402328","https://openalex.org/W2021505542","https://openalex.org/W2047279125","https://openalex.org/W2419574001"],"abstract_inverted_index":{"Large":[0],"interindividual":[1],"variations":[2,179],"of":[3,16,25,82,103,114,147,180],"nasal":[4,27,35,59,69,84,95,109,149],"mucocilliary":[5],"clearance":[6,37,61],"across":[7,45],"healthy":[8,53],"subjects":[9,123],"have":[10],"been":[11],"previously":[12],"described.":[13],"The":[14,76,92,108],"aim":[15],"this":[17],"study":[18,40],"was":[19,62,86,99,116,125,139],"to":[20,39,141,160,166,187,193],"evaluate":[21],"the":[22,26,56,65,83,104,134,142,148,161],"respective":[23],"role":[24],"mucus":[28,70,96,150,200],"quality":[29],"and":[30,38,47,71,124],"ciliary":[31,79,162],"activity":[32],"in":[33,42,57,77,93,121,133,143,199],"determining":[34],"mucociliary":[36,60,110],"changes":[41,198],"these":[43],"variables":[44],"time":[46,112],"with":[48,64,197],"environmental":[49],"conditions.":[50],"In":[51],"20":[52],"nonsmoking":[54],"volunteers,":[55],"vivo":[58],"measured":[63,182],"saccharin":[66,115],"test.":[67],"Then,":[68],"ciliated":[72],"cells":[73,85],"were":[74,191],"collected.":[75],"vitro":[78,94,144],"beat":[80],"frequency":[81,164],"evaluated":[87,100],"by":[88,101],"a":[89],"photometric":[90],"analysis.":[91],"transport":[97,111,145,201],"rate":[98,146,202],"use":[102],"frog":[105],"depleted-palate":[106],"model.":[107],"(NMTT)":[113],"greater":[117],"than":[118,156,208],"30":[119],"min":[120,129],"seven":[122],"13.6":[126],"+/-":[127,131],"6.1":[128],"(mean":[130],"SD)":[132],"remaining":[135],"13":[136],"subjects.":[137],"NMTT":[138],"correlated":[140,196],"(r":[151,203],"=":[152,204],"-0.75,":[153],"p":[154,206],"less":[155,207],"0.001),":[157],"but":[158],"not":[159],"beating":[163],"or":[165,171],"ambient":[167],"temperature,":[168],"relative":[169],"humidity,":[170],"air":[172],"pollution":[173],"indices":[174],"measured.":[175],"Moreover,":[176],"large":[177],"intraindividual":[178],"NMTT,":[181],"on":[183],"two":[184],"occasions":[185],"4":[186],"8":[188],"wk":[189],"apart,":[190],"found":[192],"be":[194],"significantly":[195],"-0.60,":[205],"0.05).":[209]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
