{"id":"https://openalex.org/W2052212954","doi":"https://doi.org/10.1097/00008390-200310000-00011","title":"Results of a phase I clinical study using autologous tumour lysate-pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2","display_name":"Results of a phase I clinical study using autologous tumour lysate-pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2","publication_year":2003,"publication_date":"2003-09-26","ids":{"openalex":"https://openalex.org/W2052212954","doi":"https://doi.org/10.1097/00008390-200310000-00011","mag":"2052212954","pmid":"https://pubmed.ncbi.nlm.nih.gov/14512794"},"language":"en","primary_location":{"id":"doi:10.1097/00008390-200310000-00011","doi":"https://doi.org/10.1097/00008390-200310000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00008390-200310000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S3207524","display_name":"Melanoma Research","issn_l":"0960-8931","issn":["0960-8931","1473-5636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Melanoma Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057052047","display_name":"Hitomi Nagayama","orcid":"https://orcid.org/0000-0002-9674-659X","observed_orcids":["https://orcid.org/0000-0002-9674-659X"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitomi Nagayama","raw_affiliation_strings":["Division of Cell Processing, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Processing, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042507670","display_name":"Katsuaki Sato","orcid":"https://orcid.org/0000-0002-1844-6620","observed_orcids":["https://orcid.org/0000-0002-1844-6620"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuaki Sato","raw_affiliation_strings":["Division of Cell Processing","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Processing","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mariko Morishita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Morishita","raw_affiliation_strings":["Department of Advanced Medical Science","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical Science","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066646106","display_name":"Kaoru Uchimaru","orcid":"https://orcid.org/0000-0002-1665-9606","observed_orcids":["https://orcid.org/0000-0002-1665-9606"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Uchimaru","raw_affiliation_strings":["Department of Advanced Medical Science","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical Science","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082649396","display_name":"Naoki Oyaizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Oyaizu","raw_affiliation_strings":["Department of Laboratory Medicine","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006982144","display_name":"Takeshi Inazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Inazawa","raw_affiliation_strings":["Department of Advanced Medical Science","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical Science","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069028829","display_name":"Tomoko Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Yamasaki","raw_affiliation_strings":["Department of Advanced Medical Science","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical Science","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Makoto Enomoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Enomoto","raw_affiliation_strings":["Division of Cell Processing","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Processing","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019652039","display_name":"Takashi Nakaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakaoka","raw_affiliation_strings":["Department of Advanced Medical Science","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical Science","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780480","display_name":"Tetsuya Nakamura","orcid":"https://orcid.org/0000-0002-4244-9119","observed_orcids":["https://orcid.org/0000-0002-4244-9119"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Nakamura","raw_affiliation_strings":["Department of Infectious Disease","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105783422","display_name":"Taira Maekawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taira Maekawa","raw_affiliation_strings":["Division of Transfusion Medicine and","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transfusion Medicine and","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046873017","display_name":"Akifumi Yamamoto","orcid":"https://orcid.org/0000-0003-0560-9969","observed_orcids":["https://orcid.org/0000-0003-0560-9969"]},"institutions":[{"id":"https://openalex.org/I4210087348","display_name":"National Cancer Centre Japan","ror":"https://ror.org/0025ww868","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akifumi Yamamoto","raw_affiliation_strings":["Division of Dermatology, National Cancer Central Hospital, Tokyo, Japan","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Dermatology, National Cancer Central Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210087348"]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105407175","display_name":"Shinji Shimada","orcid":"https://orcid.org/0000-0001-6387-3202","observed_orcids":["https://orcid.org/0000-0001-6387-3202"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Shimada","raw_affiliation_strings":["Department of Dermatology, Yamanashi Medical University, Yamanashi, Japan","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Yamanashi Medical University, Yamanashi, Japan","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083641551","display_name":"Toshiaki Saida","orcid":"https://orcid.org/0000-0003-2143-2024","observed_orcids":["https://orcid.org/0000-0003-2143-2024"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Saida","raw_affiliation_strings":["Department of Dermatology, Shinsyu University School of Medicine, Matsumoto, Japan, and","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Shinsyu University School of Medicine, Matsumoto, Japan, and","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055290282","display_name":"Yutaka Kawakami","orcid":"https://orcid.org/0000-0002-0036-1186","observed_orcids":["https://orcid.org/0000-0002-0036-1186","https://orcid.org/0000-0003-4836-2855"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Kawakami","raw_affiliation_strings":["Division of Cellular Signaling, The Institute of Advanced Medical Science, Keio University School of Medicine, Tokyo, Japan","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cellular Signaling, The Institute of Advanced Medical Science, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101101017","display_name":"Shigetaka Asano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigetaka Asano","raw_affiliation_strings":["Division of Molecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017716828","display_name":"Kenzaburo Tani","orcid":"https://orcid.org/0000-0003-3335-6188","observed_orcids":["https://orcid.org/0000-0003-3335-6188"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenzaburo Tani","raw_affiliation_strings":["Division of Molecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111870501","display_name":"Tsuneo A Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneo A Takahashi","raw_affiliation_strings":["Division of Cell Processing","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Processing","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049599825","display_name":"Naohide Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naohide Yamashita","raw_affiliation_strings":["Department of Advanced Medical Science","Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","[email\u00a0protected]","e-mail","fax: +81 3 5449 5456","requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical Science","institution_ids":[]},{"raw_affiliation_string":"Sponsorship: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail","institution_ids":[]},{"raw_affiliation_string":"fax: +81 3 5449 5456","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to N. Yamashita, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 5449 5698","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049599825"],"corresponding_institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":1.5594,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.8215901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"5","first_page":"521","last_page":"530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8140000104904175},{"id":"https://openalex.org/keywords/stage-iv-melanoma","display_name":"stage IV melanoma","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dendritic-cell-vaccination","display_name":"dendritic cell vaccination","score":0.9269999861717224},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/low-dose-il-2","display_name":"low-dose interleukin-2","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7950000166893005},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.790852427482605},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.659623384475708},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6326492428779602},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5267050862312317},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5004937648773193},{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.4955860376358032},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4841962158679962},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4794113337993622},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4304473102092743},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3110460042953491},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3080674409866333},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000075362","descriptor_name":"Leukocyte Immunoglobulin-like Receptor B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075362","descriptor_name":"Leukocyte Immunoglobulin-like Receptor B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075362","descriptor_name":"Leukocyte Immunoglobulin-like Receptor B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018949","descriptor_name":"Antigens, CD1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018949","descriptor_name":"Antigens, CD1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018949","descriptor_name":"Antigens, CD1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00008390-200310000-00011","doi":"https://doi.org/10.1097/00008390-200310000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00008390-200310000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S3207524","display_name":"Melanoma Research","issn_l":"0960-8931","issn":["0960-8931","1473-5636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Melanoma Research","raw_type":"journal-article"},{"id":"pmid:14512794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14512794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Melanoma research","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W333385333","https://openalex.org/W1483423516","https://openalex.org/W1514645352","https://openalex.org/W1571520647","https://openalex.org/W1586837651","https://openalex.org/W1761643547","https://openalex.org/W1769686661","https://openalex.org/W1992353552","https://openalex.org/W2028092080","https://openalex.org/W2058629447","https://openalex.org/W2066964346","https://openalex.org/W2067816945","https://openalex.org/W2076674215","https://openalex.org/W2086704878","https://openalex.org/W2088890805","https://openalex.org/W2094254406","https://openalex.org/W2111220263","https://openalex.org/W2117216774","https://openalex.org/W2118954607","https://openalex.org/W2131761283","https://openalex.org/W2165401836","https://openalex.org/W2170454574"],"related_works":["https://openalex.org/W2220102944","https://openalex.org/W2409441623","https://openalex.org/W1984674482","https://openalex.org/W1996150995","https://openalex.org/W4210976760","https://openalex.org/W2010436537","https://openalex.org/W1974496092","https://openalex.org/W2975472681","https://openalex.org/W2375999619","https://openalex.org/W2086478399"],"abstract_inverted_index":{"We":[0],"conducted":[1],"a":[2,42],"pilot":[3],"study":[4],"to":[5,20,71,76,85,235],"assess":[6],"the":[7,113,117,162,210],"feasibility":[8],"and":[9,45,54,102,127,136,153,188,191,201,233],"efficacy":[10,218],"of":[11,33,106,183,216],"immunotherapy":[12],"for":[13,47,99],"stage":[14],"IV":[15],"malignant":[16],"melanoma":[17,173],"patients":[18,115,236],"resistant":[19],"conventional":[21],"therapies":[22],"involving":[23],"vaccination":[24,164],"with":[25,31,50,81,96],"mature":[26],"dendritic":[27,58,175],"cells":[28,59,176],"(mDCs)":[29],"combined":[30,80],"administration":[32],"low":[34],"dose":[35],"interleukin-2.":[36],"Autologous":[37],"monocytes":[38],"were":[39,62,74,92,137,147,204],"harvested":[40],"from":[41,161,209],"single":[43],"apheresis":[44],"cultured":[46],"7":[48],"days":[49,69,167],"granulocyte-macrophage":[51],"colony-stimulating":[52],"factor":[53],"interleukin-4,":[55],"yielding":[56],"immature":[57],"(iDCs),":[60],"which":[61],"then":[63,93],"cryopreserved":[64,232],"until":[65],"use.":[66],"For":[67],"4":[68],"prior":[70],"vaccination,":[72],"iDCs":[73,187],"exposed":[75],"autologous":[77,223],"tumour":[78,82,134,224],"lysate":[79],"necrosis":[83],"factor-alpha":[84],"induce":[86],"terminal":[87],"differentiation":[88],"into":[89],"mDCs.":[90,195],"Patients":[91],"vaccinated":[94],"weekly":[95],"107":[97],"mDCs":[98,227],"10":[100,114],"weeks":[101],"given":[103,139],"350-700":[104],"kIU":[105],"interleukin-2":[107],"three":[108],"times":[109],"per":[110],"week.":[111],"Of":[112],"in":[116,207],"study,":[118],"one":[119],"showed":[120,124,129,178],"stable":[121],"disease,":[122,126],"seven":[123],"progressive":[125],"two":[128],"mixed":[130],"responses,":[131],"including":[132,149],"partial":[133],"regression,":[135],"therefore":[138],"20":[140],"additional":[141],"injections.":[142],"Only":[143],"minimal":[144],"adverse":[145],"events":[146],"noted,":[148],"localized":[150],"skin":[151],"reactions":[152],"mild":[154],"fever":[155],"(NIH-CTC":[156],"grade":[157],"0-1).":[158],"Median":[159],"survival":[160],"first":[163],"was":[165],"240":[166],"(range":[168],"31-735":[169],"days).":[170],"In":[171,196,212],"vitro,":[172],"patient-derived":[174],"(DCs)":[177],"reduced":[179,189],"cell":[180],"surface":[181],"expression":[182,193],"CD1a":[184],"antigen":[185,198,202],"on":[186,194],"CD86":[190],"HLA-DR":[192],"addition,":[197],"uptake,":[199],"chemotaxis":[200],"presentation":[203],"all":[205],"attenuated":[206],"DCs":[208],"patients.":[211],"summary,":[213],"although":[214],"improvement":[215],"clinical":[217],"will":[219],"require":[220],"further":[221],"research,":[222],"lysate-pulsed":[225],"monocyte-derived":[226],"could":[228],"be":[229],"safely":[230],"harvested,":[231],"administrated":[234],"without":[237],"obvious":[238],"complications.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2025-10-10T00:00:00"}