{"id":"https://openalex.org/W2052190826","doi":"https://doi.org/10.1117/12.2043775","title":"A prostate MRI atlas of biochemical failures following cancer treatment","display_name":"A prostate MRI atlas of biochemical failures following cancer treatment","publication_year":2014,"publication_date":"2014-03-18","ids":{"openalex":"https://openalex.org/W2052190826","doi":"https://doi.org/10.1117/12.2043775","mag":"2052190826"},"language":"en","primary_location":{"id":"doi:10.1117/12.2043775","doi":"https://doi.org/10.1117/12.2043775","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043775","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049258203","display_name":"Mirabela Rusu","orcid":"https://orcid.org/0000-0002-0372-0367","observed_orcids":["https://orcid.org/0000-0002-0372-0367"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mirabela Rusu","raw_affiliation_strings":["Case Western Reserve Univ. (United States)","Case Western Reserve University, United#N#                     States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University, United#N#                     States","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026884047","display_name":"John V. Kurhanewicz","orcid":"https://orcid.org/0000-0002-3544-5339","observed_orcids":["https://orcid.org/0000-0002-3544-5339"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Kurhanewicz","raw_affiliation_strings":["Univ. of California, San Francisco (United States)","University of California San Francisco,  United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of California, San Francisco (United States)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California San Francisco,  United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068285584","display_name":"Ashutosh Kumar Tewari","orcid":"https://orcid.org/0000-0002-3146-4524","observed_orcids":["https://orcid.org/0000-0002-3146-4524"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I4210101641","display_name":"Mount Sinai Hospital","ror":"https://ror.org/019jr0130","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101641","https://openalex.org/I4210149743"]},{"id":"https://openalex.org/I4210102044","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01h9y0t02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4210102044"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashutosh Tewari","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai Hospital (United States)","#N##TAB##TAB##TAB##TAB# Icahn School of Medicine at Mount Sinai Hospital, United States#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai Hospital (United States)","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I4210101641","https://openalex.org/I4210102044","https://openalex.org/I98704320"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Icahn School of Medicine at Mount Sinai Hospital, United States#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027642699","display_name":"Anant Madabhushi","orcid":"https://orcid.org/0000-0002-5741-0399","observed_orcids":["https://orcid.org/0000-0002-5741-0399"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anant Madabhushi","raw_affiliation_strings":["Case Western Reserve Univ. (United States)","Case Western Reserve University, United#N#                     States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve Univ. (United States)","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Case Western Reserve University, United#N#                     States","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7875,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84447096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9035","issue":null,"first_page":"903513","last_page":"903513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.08910000324249268,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prostate-mri","display_name":"prostate MRI","score":0.6359999775886536},{"id":"https://openalex.org/keywords/statistical-atlas","display_name":"statistical atlas","score":0.8230000138282776},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.8019999861717224},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8849999904632568},{"id":"https://openalex.org/keywords/prostate-capsule","display_name":"prostate capsule","score":0.6549999713897705},{"id":"https://openalex.org/keywords/central-zone","display_name":"central zone","score":0.5699999928474426},{"id":"https://openalex.org/keywords/treatment-failure-prediction","display_name":"treatment failure prediction","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.8147002458572388},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.764999508857727},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4448021650314331},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41679805517196655},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37391960620880127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35236281156539917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24796199798583984},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07824546098709106}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2043775","doi":"https://doi.org/10.1117/12.2043775","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2043775","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W172401380","https://openalex.org/W1613739536","https://openalex.org/W1973064815","https://openalex.org/W2048279620","https://openalex.org/W2088339151","https://openalex.org/W2093867637","https://openalex.org/W2107671263","https://openalex.org/W2123898563","https://openalex.org/W2132935740","https://openalex.org/W2133104280","https://openalex.org/W2140023635","https://openalex.org/W2143137267","https://openalex.org/W2144866895","https://openalex.org/W2152561234","https://openalex.org/W2156875677","https://openalex.org/W2168866947","https://openalex.org/W2294349043","https://openalex.org/W2544894372","https://openalex.org/W4230813313","https://openalex.org/W4256188663","https://openalex.org/W6643597165","https://openalex.org/W6697355909","https://openalex.org/W6729088671"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W3015759778","https://openalex.org/W2088520467","https://openalex.org/W2075763133","https://openalex.org/W2376423713","https://openalex.org/W1583600832"],"abstract_inverted_index":{"Radical":[0],"prostatectomy":[1],"(RP)":[2],"and":[3,22,26,37,59,146,175,203,229,254,284,324,340,342,354,385,403,424,434,441],"radiation":[4,20,91],"therapy":[5],"(RT)":[6],"are":[7,364,419],"the":[8,87,105,121,181,209,216,222,269,300,306,315,352,361,383,408,411,422,429,432,436,439],"most":[9],"common":[10],"treatment":[11,96,101,118],"options":[12],"for":[13,81,90,233],"prostate":[14,54,423],"cancer":[15],"(PCa).":[16],"Despite":[17],"advancements":[18],"in":[19,30,51,74,164,171,221,421,428,444,458],"delivery":[21],"surgical":[23],"procedures,":[24],"RP":[25,226],"RT":[27,228,379,460],"can":[28],"result":[29],"failure":[31,41,102,115],"rates":[32],"as":[33,35,303,456],"high":[34],"40%":[36],">25%,":[38],"respectively.":[39],"Treatment":[40],"is":[42,49,65,93,127,134],"characterized":[43],"by":[44,376],"biochemical":[45],"recurrence":[46],"(BcR),":[47],"which":[48],"defined":[50],"terms":[52,445],"of":[53,95,100,107,184,215,247,266,279,308,337,410,431,446],"specific":[55],"antigen":[56],"(PSA)":[57],"concentrations":[58,77],"its":[60,72],"variation":[61],"following":[62,69],"treatment.":[63,267,297],"PSA":[64,89],"expected":[66],"to":[67,117,129,135,189,200,333,346,381,449],"decrease":[68],"treatment,":[70],"thereby":[71],"presence":[73],"even":[75],"small":[76],"(e.g":[78],"0.2":[79],"ng/ml":[80,85],"surgery":[82],"or":[83,110,227],"2":[84],"over":[86],"nadir":[88],"therapy)":[92],"indicative":[94],"failure.":[97],"Early":[98],"identification":[99],"may":[103,119],"enable":[104],"use":[106,194],"more":[108],"aggressive":[109],"neo-adjuvant":[111],"therapies.":[112],"Moreover,":[113],"predicting":[114],"prior":[116],"spare":[120],"patient":[122,356],"from":[123,243,259,289,311],"a":[124,244,276,325],"procedure":[125],"that":[126],"unlikely":[128],"be":[130,450],"successful.":[131],"Our":[132],"goal":[133],"identify":[136,347],"differences":[137,163,170,179,350,363,399,418,437],"on":[138,158,208,275,407],"pre-treatment":[139,210],"MRI":[140,165,253,258,283,288,338,397],"between":[141,351,401,438],"patients":[142,219,260,290,380],"who":[143,148,291],"have":[144],"BcR":[145,202,239,262,353,384,402,440],"those":[147],"remain":[149,292],"disease-free":[150,293],"at":[151,234],"5":[152,236,264,294],"years":[153,265,295],"post-treatment.":[154],"Specifically,":[155],"we":[156,193,366,372,391],"focus":[157],"(1)":[159,394],"identifying":[160],"statistically":[161,348,395,415],"significant":[162,349,396,416],"intensities,":[166],"(2)":[167,414],"establishing":[168],"morphological":[169,326,362,417],"prostatic":[172,185],"anatomic":[173],"structures,":[174],"(3)":[176,435],"comparing":[177],"these":[178,191,389,453],"with":[180,261],"natural":[182],"variability":[183],"structures.":[186],"In":[187],"order":[188],"attain":[190],"objectives,":[192],"an":[195,322,368],"anatomically":[196],"constrained":[197],"registration":[198],"framework":[199,302],"construct":[201,382],"non-BcR":[204,270,355,386,404,442],"statistical":[205,327],"atlases":[206,375,455],"based":[207,274],"magnetic":[211],"resonance":[212],"images":[213,310],"(MRI)":[214],"prostate.":[217],"The":[218,238],"included":[220],"atlas":[223,240,271,301],"either":[224],"underwent":[225],"were":[230],"followed":[231],"up":[232],"least":[235],"years.":[237],"was":[241,272],"constructed":[242,373],"combined":[245,277],"population":[246],"12":[248],"pre-RT":[249,281],"1.5":[250],"Tesla":[251],"(T)":[252],"33":[255],"pre-RP":[256,286],"3T":[257,287],"within":[263],"Similarly,":[268],"built":[273],"cohort":[278],"20":[280],"1.5T":[282],"41":[285],"post":[296],"We":[298],"chose":[299],"it":[304],"enables":[305],"mapping":[307],"MR":[309],"all":[312],"subjects":[313],"into":[314],"same":[316],"canonical":[317],"space,":[318],"while":[319],"constructing":[320],"both":[321],"imaging":[323],"atlas.":[328],"Such":[329],"co-registration":[330],"allowed":[331],"us":[332],"perform":[334],"voxel-by-voxel":[335],"comparisons":[336],"intensities":[339],"capsule":[341],"central":[343,412,425],"gland":[344],"morphology":[345],"populations.":[357],"To":[358],"assess":[359],"whether":[360],"valid,":[365],"performed":[367],"additional":[369],"experiment":[370],"where":[371],"sub-population":[374,454],"randomly":[377],"sampling":[378],"atlases.":[387,461],"Following":[388],"experiments":[390],"observed":[392,457],"that:":[393],"intensity":[398],"exist":[400],"patients,":[405],"specifically":[406,427],"border":[409],"gland;":[413],"visible":[420],"gland,":[426],"proximity":[430],"apex,":[433],"cohorts":[443],"shape":[447],"appeared":[448],"consistent":[451],"across":[452],"our":[459]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
