{"id":"https://openalex.org/W2052160074","doi":"https://doi.org/10.1016/j.jss.2006.07.032","title":"The STAT4 and STAT6 Pathways in Pancreatitis-Associated Lung Injury","display_name":"The STAT4 and STAT6 Pathways in Pancreatitis-Associated Lung Injury","publication_year":2006,"publication_date":"2006-11-16","ids":{"openalex":"https://openalex.org/W2052160074","doi":"https://doi.org/10.1016/j.jss.2006.07.032","mag":"2052160074","pmid":"https://pubmed.ncbi.nlm.nih.gov/17109890"},"language":"en","primary_location":{"id":"doi:10.1016/j.jss.2006.07.032","doi":"https://doi.org/10.1016/j.jss.2006.07.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jss.2006.07.032","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028650763","display_name":"Misho O. Simovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Misho O. Simovic","raw_affiliation_strings":["Department of Surgery, Meharry Medical College, Nashville, Tennessee, USA. milomir.simovic@amedd.army.mil","Department of Surgery Meharry Medical College Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Meharry Medical College, Nashville, Tennessee, USA. milomir.simovic@amedd.army.mil","institution_ids":["https://openalex.org/I118073183"]},{"raw_affiliation_string":"Department of Surgery Meharry Medical College Nashville, Tennessee","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083619500","display_name":"Billy R. Ballard","orcid":"https://orcid.org/0000-0001-7202-2506","observed_orcids":["https://orcid.org/0000-0001-7202-2506"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Billy R. Ballard","raw_affiliation_strings":["Department of Pathology, Meharry Medical College, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Meharry Medical College, Nashville, Tennessee","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108499350","display_name":"Keith D. Gray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith D. Gray","raw_affiliation_strings":["Department of Surgical Oncology; The University of Texas; MD Anderson Cancer Center; Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology; The University of Texas; MD Anderson Cancer Center; Houston Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011676816","display_name":"Steven Charles Stain","orcid":"https://orcid.org/0000-0002-4540-7459","observed_orcids":["https://orcid.org/0000-0002-4540-7459"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Stain","raw_affiliation_strings":["Department of Surgery, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.7262,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74187953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"137","issue":"1","first_page":"10","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat4","display_name":"STAT4","score":0.9710000157356262},{"id":"https://openalex.org/keywords/stat6","display_name":"STAT6","score":1.0},{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cerulein-induced-pancreatitis","display_name":"cerulein-induced pancreatitis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pancreatitis-associated-lung-injury","display_name":"pancreatitis-associated lung injury","score":0.8579999804496765},{"id":"https://openalex.org/keywords/systemic-inflammatory-response","display_name":"systemic inflammatory response","score":0.7639999985694885},{"id":"https://openalex.org/keywords/stat6-deficient-mice","display_name":"STAT6-deficient mice","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myeloperoxidase-activity","display_name":"myeloperoxidase activity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/leukocyte-sequestration","display_name":"leukocyte sequestration","score":0.871999979019165},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.621999979019165},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.6147511601448059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6007218956947327},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5313753485679626},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5035907626152039},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.49372586607933044},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4420018196105957},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.43994659185409546},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37282001972198486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3649711608886719},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3311322331428528}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002108","descriptor_name":"Ceruletide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050797","descriptor_name":"STAT4 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050797","descriptor_name":"STAT4 Transcription Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jss.2006.07.032","doi":"https://doi.org/10.1016/j.jss.2006.07.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jss.2006.07.032","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"},{"id":"pmid:17109890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17109890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of surgical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1562554339","https://openalex.org/W1902344602","https://openalex.org/W1929136736","https://openalex.org/W1986625462","https://openalex.org/W1987435736","https://openalex.org/W2000002177","https://openalex.org/W2007433998","https://openalex.org/W2012628280","https://openalex.org/W2014237818","https://openalex.org/W2015491183","https://openalex.org/W2019454445","https://openalex.org/W2031501484","https://openalex.org/W2038060581","https://openalex.org/W2038352418","https://openalex.org/W2048046765","https://openalex.org/W2050444234","https://openalex.org/W2051292814","https://openalex.org/W2070678323","https://openalex.org/W2073025056","https://openalex.org/W2075055228","https://openalex.org/W2088406252","https://openalex.org/W2096230184","https://openalex.org/W2104886662","https://openalex.org/W2110665226","https://openalex.org/W2117342688","https://openalex.org/W2118396663","https://openalex.org/W2128635872","https://openalex.org/W2133766032","https://openalex.org/W2139287532","https://openalex.org/W2148000616","https://openalex.org/W2148996267","https://openalex.org/W2154057475","https://openalex.org/W2217143514","https://openalex.org/W2318059699","https://openalex.org/W4250194912","https://openalex.org/W4313343474"],"related_works":["https://openalex.org/W2152847211","https://openalex.org/W7118207501","https://openalex.org/W2127766923","https://openalex.org/W3034006693","https://openalex.org/W2060094520","https://openalex.org/W2054982013","https://openalex.org/W575543055","https://openalex.org/W2154069286","https://openalex.org/W2243395523","https://openalex.org/W2143659918"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}