{"id":"https://openalex.org/W2052159235","doi":"https://doi.org/10.2174/1568009033481723","title":"Cyclooxygenase Inhibition and Mechanisms of Colorectal Cancer Prevention","display_name":"Cyclooxygenase Inhibition and Mechanisms of Colorectal Cancer Prevention","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2052159235","doi":"https://doi.org/10.2174/1568009033481723","mag":"2052159235","pmid":"https://pubmed.ncbi.nlm.nih.gov/14683503"},"language":"en","primary_location":{"id":"doi:10.2174/1568009033481723","doi":"https://doi.org/10.2174/1568009033481723","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568009033481723","pdf_url":null,"source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080223712","display_name":"Timothy An-thy Chan","orcid":"https://orcid.org/0000-0002-9265-0283","observed_orcids":["https://orcid.org/0000-0002-9265-0283"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy Chan","raw_affiliation_strings":["Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA. tim@jhmi.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA. tim@jhmi.edu","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080223712"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":1.4189,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79108495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"6","first_page":"455","last_page":"463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9909999966621399},{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":0.902999997138977},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":1.0},{"id":"https://openalex.org/keywords/cox-independent-mechanism","display_name":"COX-independent mechanism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2778582115","wikidata":"https://www.wikidata.org/wiki/Q411412","display_name":"Rofecoxib","level":4,"score":0.896879255771637},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8736480474472046},{"id":"https://openalex.org/C2776467144","wikidata":"https://www.wikidata.org/wiki/Q408801","display_name":"Celecoxib","level":2,"score":0.8306546211242676},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.7861372232437134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7720991373062134},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6096253991127014},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5636036396026611},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.5413200259208679},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.5134447813034058},{"id":"https://openalex.org/C111669997","wikidata":"https://www.wikidata.org/wiki/Q17163050","display_name":"Mouse model of colorectal and intestinal cancer","level":4,"score":0.5057950019836426},{"id":"https://openalex.org/C2776241388","wikidata":"https://www.wikidata.org/wiki/Q963093","display_name":"Sulindac","level":3,"score":0.4494134187698364},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39645764231681824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3323062062263489},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2513468265533447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11544471979141235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1568009033481723","doi":"https://doi.org/10.2174/1568009033481723","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568009033481723","pdf_url":null,"source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},{"id":"pmid:14683503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14683503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current cancer drug targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149752901","https://openalex.org/W2091356364","https://openalex.org/W2416779664","https://openalex.org/W2092436048","https://openalex.org/W1991020112","https://openalex.org/W2057249811","https://openalex.org/W2410413326","https://openalex.org/W2009468207","https://openalex.org/W2088905899","https://openalex.org/W1533049846"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,7,20,73],"is":[2,89,138],"a":[3],"leading":[4],"cause":[5],"of":[6,82,95,125,148],"death":[8],"throughout":[9],"the":[10,34,43,83,92,145],"world.":[11],"The":[12],"high":[13],"prevalence":[14],"and":[15,24,30,57,62,87,129,136],"mortality":[16],"associated":[17],"with":[18,64],"colon":[19],"make":[21],"effective":[22],"prevention":[23],"treatment":[25],"an":[26],"important":[27],"public":[28],"health":[29],"economic":[31],"concern.":[32],"Among":[33],"few":[35],"agents":[36,53],"known":[37,78],"to":[38,79,103,106],"inhibit":[39,107],"colorectal":[40],"tumorigenesis":[41],"are":[42,76,97,132,142],"nonsteroidal":[44],"anti-inflammatory":[45],"drugs":[46],"or":[47],"NSAIDs,":[48],"as":[49,51,55],"well":[50],"newer":[52],"such":[54],"celecoxib":[56],"rofecoxib.":[58],"Both":[59],"epidemiologic":[60],"studies":[61],"investigations":[63],"animals":[65],"show":[66],"that":[67,91,115,140],"these":[68],"compounds":[69],"possess":[70],"marked":[71],"anti-colorectal":[72],"properties.":[74],"NSAIDS":[75],"widely":[77],"be":[80],"inhibitors":[81],"cyclooxygenase":[84],"(COX)":[85],"enzymes,":[86],"it":[88,137],"thought":[90],"chemopreventive":[93],"effects":[94,121],"NSAIDs":[96,116],"at":[98],"least":[99],"in":[100,144],"part":[101],"due":[102],"this":[104],"ability":[105],"COX.":[108],"More":[109],"recent":[110],"studies,":[111],"however,":[112],"have":[113],"suggested":[114],"may":[117],"also":[118],"exert":[119],"anti-cancer":[120],"through":[122],"mechanisms":[123,131],"independent":[124],"COX":[126],"inhibition.":[127],"COX-dependent":[128],"COX-independent":[130],"not":[133],"mutually":[134],"exclusive":[135],"likely":[139],"both":[141],"involved":[143],"biological":[146],"activity":[147],"NSAIDs.":[149]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
