{"id":"https://openalex.org/W2052106921","doi":"https://doi.org/10.1016/j.ejphar.2006.06.049","title":"Characterisation of the relaxant response to raloxifene in porcine coronary arteries","display_name":"Characterisation of the relaxant response to raloxifene in porcine coronary arteries","publication_year":2006,"publication_date":"2006-06-29","ids":{"openalex":"https://openalex.org/W2052106921","doi":"https://doi.org/10.1016/j.ejphar.2006.06.049","mag":"2052106921","pmid":"https://pubmed.ncbi.nlm.nih.gov/16859668"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejphar.2006.06.049","doi":"https://doi.org/10.1016/j.ejphar.2006.06.049","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2006.06.049","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043340610","display_name":"Alkje Moritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alkje Moritz","raw_affiliation_strings":["Free University of Berlin, Institute of Pharmacy, K\u00f6nigin-Luise-Str. 2+4, 14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Free University of Berlin, Institute of Pharmacy, K\u00f6nigin-Luise-Str. 2+4, 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109241978","display_name":"Oliver A. Radtke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver A. Radtke","raw_affiliation_strings":["Free University of Berlin, Institute of Pharmacy, K\u00f6nigin-Luise-Str. 2+4, 14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Free University of Berlin, Institute of Pharmacy, K\u00f6nigin-Luise-Str. 2+4, 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057876555","display_name":"Ronald Gust","orcid":"https://orcid.org/0000-0002-0427-4012","observed_orcids":["https://orcid.org/0000-0002-0427-4012"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ronald Gust","raw_affiliation_strings":["Free University of Berlin, Institute of Pharmacy, K\u00f6nigin-Luise-Str. 2+4, 14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Free University of Berlin, Institute of Pharmacy, K\u00f6nigin-Luise-Str. 2+4, 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027218523","display_name":"Erika Glusa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erika Glusa","raw_affiliation_strings":["Friedrich-Schiller-University, Institute of Pharmacy, 07743 Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Schiller-University, Institute of Pharmacy, 07743 Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108467289","display_name":"Heinz H. Pertz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Heinz H. Pertz","raw_affiliation_strings":["Free University of Berlin, Institute of Pharmacy, K\u00f6nigin-Luise-Str. 2+4, 14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Free University of Berlin, Institute of Pharmacy, K\u00f6nigin-Luise-Str. 2+4, 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108467289"],"corresponding_institution_ids":["https://openalex.org/I75951250"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.6595,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.61356395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"545","issue":"2-3","first_page":"153","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.8429999947547913},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.7720000147819519},{"id":"https://openalex.org/keywords/bay-k-8644","display_name":"Bay K 8644","score":0.9290000200271606},{"id":"https://openalex.org/keywords/calcium-induced-contraction","display_name":"calcium-induced contraction","score":0.5609999895095825},{"id":"https://openalex.org/keywords/endothelium-independent-relaxation","display_name":"endothelium-independent relaxation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.8769999742507935},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.652999997138977},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.6309999823570251},{"id":"https://openalex.org/keywords/bapta-am","display_name":"BAPTA-AM","score":0.7710000276565552},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.7630000114440918},{"id":"https://openalex.org/keywords/potassium-induced-contraction","display_name":"potassium-induced contraction","score":0.6110000014305115},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2779889926","wikidata":"https://www.wikidata.org/wiki/Q425223","display_name":"Raloxifene","level":5,"score":0.8528279066085815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7025607228279114},{"id":"https://openalex.org/C2780019300","wikidata":"https://www.wikidata.org/wiki/Q4834614","display_name":"BAPTA","level":3,"score":0.5121831893920898},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4703260660171509},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.46746066212654114},{"id":"https://openalex.org/C2781391105","wikidata":"https://www.wikidata.org/wiki/Q4874027","display_name":"Bay K8644","level":4,"score":0.46301504969596863},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.4618057608604431},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.46021923422813416},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.4401228427886963},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4161432981491089},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4021371304988861},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.31056636571884155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22941464185714722},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077267","descriptor_name":"Fulvestrant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020849","descriptor_name":"Raloxifene Hydrochloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejphar.2006.06.049","doi":"https://doi.org/10.1016/j.ejphar.2006.06.049","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2006.06.049","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:16859668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16859668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W105631879","https://openalex.org/W1593442063","https://openalex.org/W1979492130","https://openalex.org/W1982581933","https://openalex.org/W1987144846","https://openalex.org/W1991320821","https://openalex.org/W1994001086","https://openalex.org/W2006224324","https://openalex.org/W2013242725","https://openalex.org/W2017735744","https://openalex.org/W2019143945","https://openalex.org/W2023039493","https://openalex.org/W2029599759","https://openalex.org/W2038482691","https://openalex.org/W2040625879","https://openalex.org/W2043687239","https://openalex.org/W2043909215","https://openalex.org/W2049042206","https://openalex.org/W2058673224","https://openalex.org/W2065644649","https://openalex.org/W2075108593","https://openalex.org/W2075186943","https://openalex.org/W2111828569","https://openalex.org/W2127830701","https://openalex.org/W2128635872","https://openalex.org/W2129599776","https://openalex.org/W2130235602","https://openalex.org/W2137034904","https://openalex.org/W2140649909","https://openalex.org/W2144480912","https://openalex.org/W2147184135","https://openalex.org/W2147574730","https://openalex.org/W2319696410","https://openalex.org/W2409728396","https://openalex.org/W2990290773","https://openalex.org/W6678832104"],"related_works":["https://openalex.org/W1984374719","https://openalex.org/W2058673224","https://openalex.org/W2111828569","https://openalex.org/W2319696410","https://openalex.org/W2040449469","https://openalex.org/W2763215907","https://openalex.org/W2584304533","https://openalex.org/W2033197930","https://openalex.org/W2075186943","https://openalex.org/W2144480912"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}