{"id":"https://openalex.org/W2052093973","doi":"https://doi.org/10.1152/ajpheart.00755.2006","title":"The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NO\u2022 response of isolated rat aorta","display_name":"The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress-induced impairment of the NO\u2022 response of isolated rat aorta","publication_year":2006,"publication_date":"2006-12-16","ids":{"openalex":"https://openalex.org/W2052093973","doi":"https://doi.org/10.1152/ajpheart.00755.2006","mag":"2052093973","pmid":"https://pubmed.ncbi.nlm.nih.gov/17172277"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00755.2006","doi":"https://doi.org/10.1152/ajpheart.00755.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00755.2006","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027814932","display_name":"Saskia J. Rietjens","orcid":"https://orcid.org/0000-0002-0338-1350","observed_orcids":["https://orcid.org/0000-0002-0338-1350"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"S. J. Rietjens","raw_affiliation_strings":["Departments of 1Pharmacology and Toxicology, Faculty of Medicine, Maastricht University, Maastricht, The Netherlands. S.Rietjens@farmaco.unimaas.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Pharmacology and Toxicology, Faculty of Medicine, Maastricht University, Maastricht, The Netherlands. S.Rietjens@farmaco.unimaas.nl","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084729994","display_name":"Aalt Bast","orcid":"https://orcid.org/0000-0002-5383-2789","observed_orcids":["https://orcid.org/0000-0002-5383-2789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Bast","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006733216","display_name":"Jan de Vente","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. de Vente","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074288572","display_name":"Guido R.M.M. Haenen","orcid":"https://orcid.org/0000-0001-6986-290X","observed_orcids":["https://orcid.org/0000-0001-6986-290X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. R. M. M. Haenen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8631,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.83513535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"292","issue":"4","first_page":"H1931","last_page":"H1936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.16050000488758087,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.13130000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxytyrosol","display_name":"hydroxytyrosol","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8859999775886536},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.890999972820282},{"id":"https://openalex.org/keywords/cumene-hydroperoxide","display_name":"cumene hydroperoxide","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hydroxyl-radical-scavenging","display_name":"hydroxyl radical scavenging","score":0.9729999899864197},{"id":"https://openalex.org/keywords/oleuropein","display_name":"oleuropein","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tyrosol","display_name":"tyrosol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mediterranean-diet","display_name":"Mediterranean diet","score":0.7319999933242798},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9570000171661377},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.6510000228881836},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.49799999594688416},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2775881703","wikidata":"https://www.wikidata.org/wiki/Q744577","display_name":"Hydroxytyrosol","level":4,"score":0.9937642216682434},{"id":"https://openalex.org/C2781397249","wikidata":"https://www.wikidata.org/wiki/Q402607","display_name":"Tyrosol","level":3,"score":0.9480871558189392},{"id":"https://openalex.org/C2777957096","wikidata":"https://www.wikidata.org/wiki/Q402625","display_name":"Oleuropein","level":3,"score":0.7766743898391724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.767749547958374},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7016302347183228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4802320599555969},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4471820890903473},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41694408655166626},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.14776232838630676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12078708410263062}],"mesh":[{"descriptor_ui":"D000069463","descriptor_name":"Olive Oil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010626","descriptor_name":"Phenylethyl Alcohol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010626","descriptor_name":"Phenylethyl Alcohol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010626","descriptor_name":"Phenylethyl Alcohol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010938","descriptor_name":"Plant Oils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D038441","descriptor_name":"Diet, Mediterranean","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1152/ajpheart.00755.2006","doi":"https://doi.org/10.1152/ajpheart.00755.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00755.2006","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:17172277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17172277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/fd89ca71-3b91-4f2b-a5f2-a19f2572e972","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/fd89ca71-3b91-4f2b-a5f2-a19f2572e972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rietjens, S J, Bast, A, Vente, J D & Haenen, G 2007, 'The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress induced impairment of the NO{middle dot} response of isolated rat aorta', American Journal of Physiology-heart and Circulatory Physiology, vol. 292, no. 4, pp. H1931-H1936. https://doi.org/10.1152/ajpheart.00755.2006","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/fd89ca71-3b91-4f2b-a5f2-a19f2572e972","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/fd89ca71-3b91-4f2b-a5f2-a19f2572e972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Physiology-heart and Circulatory Physiology, 292(4), H1931 - H1936. American Physiological Society","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2496254202","doi":null,"is_oa":false,"landing_page_url":"https://ajpheart.physiology.org/content/ajpheart/292/4/H1931.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1975910971","https://openalex.org/W1983469840","https://openalex.org/W1994968099","https://openalex.org/W2004594798","https://openalex.org/W2013807245","https://openalex.org/W2024682242","https://openalex.org/W2024716555","https://openalex.org/W2025759106","https://openalex.org/W2026701024","https://openalex.org/W2037353493","https://openalex.org/W2048138051","https://openalex.org/W2069384383","https://openalex.org/W2084023771","https://openalex.org/W2089253928","https://openalex.org/W2097668260","https://openalex.org/W2101575023","https://openalex.org/W2102159876","https://openalex.org/W2114364424","https://openalex.org/W2125300901","https://openalex.org/W2129241344","https://openalex.org/W2324841714"],"related_works":["https://openalex.org/W2496254202","https://openalex.org/W2009838519","https://openalex.org/W2346184686","https://openalex.org/W2300931860","https://openalex.org/W4250037275","https://openalex.org/W1179117664","https://openalex.org/W2528927033","https://openalex.org/W2093626405","https://openalex.org/W2020105561","https://openalex.org/W2530681136"],"abstract_inverted_index":{"The":[0,217],"Mediterranean":[1,234],"diet,":[2],"which":[3,23,76,130,182],"is":[4,8,77,131],"abundant":[5],"in":[6,111,127,208],"antioxidants,":[7],"associated":[9],"with":[10],"a":[11,109,125,132,163,178,221],"relatively":[12],"low":[13],"incidence":[14],"of":[15,34,42,52,82,93,151,166,191,227,232],"coronary":[16,137],"heart":[17,138],"disease.":[18,139],"Olive":[19],"oil":[20],"and":[21,29,55,122,160,205,211],"olives,":[22],"contain":[24],"the":[25,40,46,56,80,90,97,119,145,148,152,209,214,225,230,233],"antioxidants":[26,60],"hydroxytyrosol,":[27,167],"oleuropein,":[28],"tyrosol,":[30,159],"are":[31],"important":[32],"components":[33],"this":[35,38],"diet.":[36,235],"In":[37],"study,":[39],"effects":[41],"oxidative":[43,70],"stress":[44,71],"on":[45],"nitric":[47],"oxide":[48],"radical":[49],"(NO(*))-mediated":[50],"relaxation":[51,92,117,154],"rat":[53,94],"aorta":[54,95,146],"protection":[57,207],"by":[58,73,79,96],"these":[59],"were":[61],"determined.":[62],"Cumene":[63],"hydroperoxide":[64],"(CHP)":[65],"was":[66,106,174],"used":[67],"to":[68,108,124,176,186,229],"mimic":[69],"induced":[72],"lipid":[74],"hydroperoxides,":[75],"mediated":[78],"formation":[81],"hydroxyl":[83],"radicals":[84],"(OH(*)).":[85],"CHP":[86],"(300":[87],"microM)":[88,142],"impaired":[89],"NO(*)-mediated":[91,116,153],"acetylcholine":[98],"receptor":[99],"agonist":[100],"carbachol":[101],"(P":[102,155],"<":[103,156],"0.05).":[104,157],"This":[105],"due":[107],"reduction":[110],"NO(*)":[112],"production.":[113],"A":[114],"diminished":[115],"disturbs":[118],"vascular":[120],"tone":[121],"leads":[123],"rise":[126],"blood":[128],"pressure,":[129],"well-established":[133],"risk":[134],"factor":[135],"for":[136,224],"Hydroxytyrosol":[140],"(10":[141],"efficiently":[143],"protected":[144],"against":[147],"CHP-induced":[149],"impairment":[150],"Oleuropein,":[158],"homovanillic":[161],"alcohol,":[162],"major":[164],"metabolite":[165],"did":[168],"not":[169],"show":[170],"protection.":[171],"Moreover,":[172],"hydroxytyrosol":[173,200,228],"found":[175],"be":[177,184],"potent":[179],"OH(*)":[180],"scavenger,":[181],"can":[183],"attributed":[185],"its":[187,192],"catechol":[188],"moiety.":[189],"Because":[190],"amphiphilic":[193],"characteristics":[194],"(octanol-water":[195],"partitioning":[196],"coefficient":[197],"=":[198],"1.1),":[199],"will":[201],"readily":[202],"cross":[203],"membranes":[204],"provide":[206],"cytosol":[210],"membranes,":[212],"including":[213],"water-lipid":[215],"interface.":[216],"present":[218],"study":[219],"provides":[220],"molecular":[222],"basis":[223],"contribution":[226],"benefits":[231]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
