{"id":"https://openalex.org/W2052008941","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02111.x","title":"Mitochondrial DNA Deletion Mutations and Sarcopenia","display_name":"Mitochondrial DNA Deletion Mutations and Sarcopenia","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2052008941","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02111.x","mag":"2052008941","pmid":"https://pubmed.ncbi.nlm.nih.gov/11976214"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.2002.tb02111.x","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02111.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2002.tb02111.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027323609","display_name":"Judd M. Aiken","orcid":"https://orcid.org/0000-0001-6119-4521","observed_orcids":["https://orcid.org/0000-0001-6119-4521"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"JUDD AIKEN","raw_affiliation_strings":["Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. aiken@ahabs.wisc.edu","Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. aiken@ahabs.wisc.edu","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055756930","display_name":"Entela A. Bua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ENTELA BUA","raw_affiliation_strings":["Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024014571","display_name":"Zhengjin Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ZHENGJIN CAO","raw_affiliation_strings":["Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024628938","display_name":"Marisol E. Lopez","orcid":"https://orcid.org/0000-0001-9412-524X","observed_orcids":["https://orcid.org/0000-0001-9412-524X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARISOL LOPEZ","raw_affiliation_strings":["Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066563633","display_name":"Jonathan Wanagat","orcid":"https://orcid.org/0000-0002-8460-8616","observed_orcids":["https://orcid.org/0000-0002-8460-8616"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JON WANAGAT","raw_affiliation_strings":["Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018071821","display_name":"Debbie I. McKenzie","orcid":"https://orcid.org/0000-0002-9291-6977","observed_orcids":["https://orcid.org/0000-0002-9291-6977"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DEBBIE McKENZIE","raw_affiliation_strings":["Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028985183","display_name":"Susan H. McKiernan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SUSAN McKIERNAN","raw_affiliation_strings":["Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Health and Biomedical Sciences, University of Wisconsin\u2014Madison, Madison, Wisconsin 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027323609"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":1.0517,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.72755611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"959","issue":"1","first_page":"412","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.13809999823570251,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/skeletal-muscle-aging","display_name":"skeletal muscle aging","score":0.8460000157356262},{"id":"https://openalex.org/keywords/muscle-fiber-atrophy","display_name":"muscle fiber atrophy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/laser-capture-microdissection","display_name":"laser capture microdissection","score":0.7440000176429749},{"id":"https://openalex.org/keywords/rectus-femoris","display_name":"rectus femoris","score":0.8619999885559082},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.8154306411743164},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7712260484695435},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7482213377952576},{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.6912388801574707},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6448421478271484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6093379855155945},{"id":"https://openalex.org/C11242284","wikidata":"https://www.wikidata.org/wiki/Q4293202","display_name":"Microdissection","level":3,"score":0.5272181034088135},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3316260278224945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32332900166511536},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32120442390441895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28895968198776245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20441541075706482},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09733560681343079}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.2002.tb02111.x","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02111.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2002.tb02111.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:11976214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11976214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6188760403","display_name":"CARDIAC ABNORMALITIES &CALORIC RESTRICTION","funder_award_id":"R01AG017543","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8322297739","display_name":"Dietary Restriction, mt DNA Abnormalities and Aging","funder_award_id":"R01AG011604","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8708270631","display_name":"Dietary Restriction and Aging in Rhesus Monkeys","funder_award_id":"P01AG011915","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000875761","display_name":"Biology of Aging and Age-Related Diseases","funder_award_id":"T32AG000213","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1887455807","https://openalex.org/W1970268474","https://openalex.org/W1971104692","https://openalex.org/W1974396693","https://openalex.org/W1983422827","https://openalex.org/W2002736146","https://openalex.org/W2005261119","https://openalex.org/W2015411189","https://openalex.org/W2028483364","https://openalex.org/W2031619656","https://openalex.org/W2036383607","https://openalex.org/W2038484930","https://openalex.org/W2050303681","https://openalex.org/W2050821204","https://openalex.org/W2057645411","https://openalex.org/W2059371704","https://openalex.org/W2063301281","https://openalex.org/W2065275761","https://openalex.org/W2083109098","https://openalex.org/W2091199047","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2057645411","https://openalex.org/W2054511417","https://openalex.org/W4413845317","https://openalex.org/W1545655486","https://openalex.org/W2031619656","https://openalex.org/W2063301281","https://openalex.org/W2804569623","https://openalex.org/W2119019176","https://openalex.org/W2507891142","https://openalex.org/W4248712948"],"abstract_inverted_index":{"This":[0],"manuscript":[1],"summarizes":[2],"our":[3],"studies":[4,86],"on":[5],"mitochondrial":[6],"DNA":[7],"and":[8,26,57,128,137,167,173],"enzymatic":[9,58],"abnormalities":[10,59,90],"that":[11,88],"accumulate,":[12],"with":[13,48,103,157,162,169],"age,":[14,158],"in":[15,23,29,35,60,68,112],"skeletal":[16,62,153],"muscle.":[17],"Specific":[18],"quadricep":[19],"muscles,":[20],"rectus":[21],"femoris":[22],"the":[24,30,43,104,138,142,163],"rat":[25],"vastus":[27],"lateralis":[28],"rhesus":[31],"monkey,":[32],"were":[33],"used":[34],"these":[36,145],"studies.":[37],"These":[38,85],"muscles":[39],"exhibit":[40],"considerable":[41],"sarcopenia,":[42],"loss":[44,156],"of":[45,53,98,122,144],"muscle":[46,63,71,100,154,170],"mass":[47],"age.":[49],"The":[50],"focal":[51],"accumulation":[52],"mtDNA":[54,134,164],"deletion":[55,135,165],"mutations":[56,136],"aged":[61,99],"necessitates":[64],"a":[65,130,149,159],"histologic":[66,126],"approach":[67],"which":[69],"every":[70],"fiber":[72,115,155,171],"is":[73],"examined":[74],"for":[75,152],"electron":[76],"transport":[77],"system":[78],"(ETS)":[79],"enzyme":[80],"activity":[81],"along":[82],"its":[83],"length.":[84],"demonstrate":[87],"ETS":[89,105,139],"accumulate":[91],"to":[92],"high":[93],"levels":[94],"within":[95],"small":[96],"regions":[97],"fibers.":[101],"Concomitant":[102],"abnormalities,":[106],"we":[107,147],"observe":[108],"intrafiber":[109],"atrophy":[110],"and,":[111],"many":[113],"cases,":[114],"breakage.":[116],"Laser":[117],"capture":[118],"microdissection":[119],"facilitates":[120],"analysis":[121],"individual":[123],"fibers":[124],"from":[125],"sections":[127],"demonstrates":[129],"tight":[131],"association":[132],"between":[133],"abnormalities.":[140],"On":[141],"basis":[143,151],"results,":[146],"propose":[148],"molecular":[150],"process":[160],"beginning":[161],"event":[166],"culminating":[168],"breakage":[172],"loss.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
