{"id":"https://openalex.org/W2051980442","doi":"https://doi.org/10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n","title":"A simple synthetic route to the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine for the fabrication of functionalized, degradable structures for biomedical applications","display_name":"A simple synthetic route to the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine for the fabrication of functionalized, degradable structures for biomedical applications","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2051980442","doi":"https://doi.org/10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n","mag":"2051980442","pmid":"https://pubmed.ncbi.nlm.nih.gov/11319743"},"language":"en","primary_location":{"id":"doi:10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n","doi":"https://doi.org/10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079335476","display_name":"Erin Lavik","orcid":"https://orcid.org/0000-0002-0644-744X","observed_orcids":["https://orcid.org/0000-0002-0644-744X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin B. Lavik","raw_affiliation_strings":["Department of Materials Science and Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, Massachusetts 02139, USA","Department of Materials Science and Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055252245","display_name":"Jeffrey S. Hrkach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey S. Hrkach","raw_affiliation_strings":["Advanced Inhalation Research, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Inhalation Research, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061600138","display_name":"Noah Lotan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Noah Lotan","raw_affiliation_strings":["Department of Biomedical Engineering, Technion Israel Institute of Technology, Haifa, Israel 32000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Technion Israel Institute of Technology, Haifa, Israel 32000","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083172944","display_name":"Rina Nazarov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rina Nazarov","raw_affiliation_strings":["Department of Chemical Engineering, University of Connecticut, Storrs, Connecticut 06061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Connecticut, Storrs, Connecticut 06061","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042597057","display_name":"R\u00f3bert Langer","orcid":"https://orcid.org/0000-0003-4255-0492","observed_orcids":["https://orcid.org/0000-0003-4255-0492","https://orcid.org/0000-0001-5746-9940"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Langer","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042597057"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":1.3493,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.77440396,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"58","issue":"3","first_page":"291","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11471","display_name":"Block Copolymer Self-Assembly","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/block-copolymers","display_name":"block copolymers","score":0.7369999885559082},{"id":"https://openalex.org/keywords/poly-lactic-co-glycolic-acid","display_name":"poly(lactic-co-glycolic acid)","score":0.9860000014305115},{"id":"https://openalex.org/keywords/polylysine","display_name":"polylysine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dicyclohexylcarbodiimide","display_name":"dicyclohexylcarbodiimide","score":0.828000009059906},{"id":"https://openalex.org/keywords/degradable-polymers","display_name":"degradable polymers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/functionalized-biomaterials","display_name":"functionalized biomaterials","score":0.7080000042915344},{"id":"https://openalex.org/keywords/biomedical-applications","display_name":"biomedical applications","score":0.5680000185966492},{"id":"https://openalex.org/keywords/polymer-solubility","display_name":"polymer solubility","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780472526","wikidata":"https://www.wikidata.org/wiki/Q409373","display_name":"Glycolic acid","level":4,"score":0.9043979644775391},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.8413764834403992},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7194784879684448},{"id":"https://openalex.org/C2780075363","wikidata":"https://www.wikidata.org/wiki/Q650157","display_name":"Polylysine","level":2,"score":0.6276570558547974},{"id":"https://openalex.org/C2775997276","wikidata":"https://www.wikidata.org/wiki/Q420241","display_name":"Carbodiimide","level":2,"score":0.5733453035354614},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5516975522041321},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.4815947711467743},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.45451825857162476},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.40783241391181946},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33772680163383484},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2329685091972351},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17610964179039001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001673","descriptor_name":"Biodegradation, Environmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004024","descriptor_name":"Dicyclohexylcarbodiimide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011107","descriptor_name":"Polylysine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011107","descriptor_name":"Polylysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n","doi":"https://doi.org/10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},{"id":"doi:10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.3.co;2-e","doi":"https://doi.org/10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.3.co;2-e","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.3.co;2-e","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},{"id":"pmid:11319743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11319743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7033315665","display_name":"Vascularization of engineered cardiac tissue","funder_award_id":"R01HL060435","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W653459322","https://openalex.org/W1989841409","https://openalex.org/W1990879541","https://openalex.org/W2001197917","https://openalex.org/W2028014348","https://openalex.org/W2041291907","https://openalex.org/W2045097923","https://openalex.org/W2045613923","https://openalex.org/W2113220146","https://openalex.org/W2341075143","https://openalex.org/W2485201588","https://openalex.org/W4246495419","https://openalex.org/W6814410989","https://openalex.org/W7074564710"],"related_works":["https://openalex.org/W2084918292","https://openalex.org/W2066489104","https://openalex.org/W2027731541","https://openalex.org/W2105879487","https://openalex.org/W2655646808","https://openalex.org/W2198527287","https://openalex.org/W1984896027","https://openalex.org/W2362578460","https://openalex.org/W2147472360","https://openalex.org/W761950698"],"abstract_inverted_index":{"This":[0],"article":[1],"documents":[2],"the":[3,51,59,67],"formation":[4,60],"of":[5,9,44,61,69],"a":[6,15,41,53],"block":[7,64],"copolymer":[8],"poly(lactic-co-glycolic":[10],"acid)":[11],"and":[12,35,46,55],"polylysine":[13],"via":[14,29],"simple":[16,54],"coupling":[17],"technique":[18,52],"using":[19],"dicyclohexyl":[20],"carbodiimide":[21],"(DCC).":[22],"The":[23],"resulting":[24],"polymer":[25],"has":[26],"been":[27],"characterized":[28],"UV-Vis":[30],"spectroscopy,":[31],"GPC,":[32],"(1)H":[33],"NMR,":[34],"elemental":[36],"analysis,":[37],"is":[38,47],"soluble":[39],"in":[40],"wide":[42],"variety":[43],"solvents,":[45],"easily":[48],"processable,":[49],"making":[50],"practical":[56],"one":[57],"for":[58,66,72],"functionalized,":[62],"degradable":[63],"copolymers":[65],"fabrication":[68],"functionalized":[70],"structures":[71],"biomedical":[73],"applications.":[74]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
