{"id":"https://openalex.org/W2051969893","doi":"https://doi.org/10.1186/1471-2466-14-173","title":"Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD","display_name":"Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD","publication_year":2014,"publication_date":"2014-11-04","ids":{"openalex":"https://openalex.org/W2051969893","doi":"https://doi.org/10.1186/1471-2466-14-173","mag":"2051969893","pmid":"https://pubmed.ncbi.nlm.nih.gov/25369941","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4228268"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2466-14-173","doi":"https://doi.org/10.1186/1471-2466-14-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2466-14-173","pdf_url":"https://bmcpulmmed.biomedcentral.com/counter/pdf/10.1186/1471-2466-14-173","source":{"id":"https://openalex.org/S204956882","display_name":"BMC Pulmonary Medicine","issn_l":"1471-2466","issn":["1471-2466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Pulmonary Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcpulmmed.biomedcentral.com/counter/pdf/10.1186/1471-2466-14-173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115596173","display_name":"Xinyan Wang","orcid":"https://orcid.org/0000-0001-5428-4916","observed_orcids":["https://orcid.org/0000-0001-5428-4916"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyan Wang","raw_affiliation_strings":["Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China","institution_ids":["https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320147","display_name":"Li Wan","orcid":"https://orcid.org/0009-0002-1858-9522","observed_orcids":["https://orcid.org/0009-0002-1858-9522"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101515041","display_name":"Kun Huang","orcid":"https://orcid.org/0000-0001-7427-9647","observed_orcids":["https://orcid.org/0000-0001-7427-9647"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Huang","raw_affiliation_strings":["Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China","institution_ids":["https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088076540","display_name":"Xiaowen Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowen Kang","raw_affiliation_strings":["Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China","institution_ids":["https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101427092","display_name":"Zhaoguo Li","orcid":"https://orcid.org/0000-0002-4791-5537","observed_orcids":["https://orcid.org/0000-0002-4791-5537"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoguo Li","raw_affiliation_strings":["Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China","institution_ids":["https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100737723","display_name":"Chengcheng Yang","orcid":"https://orcid.org/0000-0003-2019-3623","observed_orcids":["https://orcid.org/0000-0003-2019-3623"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengcheng Yang","raw_affiliation_strings":["Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"Department of Respiratory The Second Affiliated Hospital of Harbin Medical University  Harbin China","institution_ids":["https://openalex.org/I4210132813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101499035","display_name":"Xiaomei Wu","orcid":"https://orcid.org/0000-0003-2915-3513","observed_orcids":["https://orcid.org/0000-0003-2915-3513"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210132813","display_name":"Second Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/03s8txj32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132813"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaomei Wu","raw_affiliation_strings":["Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. wu.xiaomei@hotmail.com","Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. wu.xiaomei@hotmail.com","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]},{"raw_affiliation_string":"Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052525388","display_name":"Lina Chen","orcid":"https://orcid.org/0000-0002-4576-6814","observed_orcids":["https://orcid.org/0000-0002-4576-6814"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lina Chen","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052525388","https://openalex.org/A5101499035"],"corresponding_institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210132813"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.4742,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.68284413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"1","first_page":"173","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adam33","display_name":"ADAM33","score":0.9729999899864197},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9629999995231628},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.9610000252723694},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8119999766349792},{"id":"https://openalex.org/keywords/east-asian-populations","display_name":"East Asian populations","score":0.7369999885559082},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8353918790817261},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8352079391479492},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.584924042224884},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5817242860794067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5784918665885925},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5344905853271484},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.48870041966438293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2417239248752594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11549574136734009},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10333067178726196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08468294143676758},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08459600806236267},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005202","descriptor_name":"Asia, Eastern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051722","descriptor_name":"ADAM Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2466-14-173","doi":"https://doi.org/10.1186/1471-2466-14-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2466-14-173","pdf_url":"https://bmcpulmmed.biomedcentral.com/counter/pdf/10.1186/1471-2466-14-173","source":{"id":"https://openalex.org/S204956882","display_name":"BMC Pulmonary Medicine","issn_l":"1471-2466","issn":["1471-2466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Pulmonary Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3197808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4228268","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25369941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25369941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC pulmonary medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4228268","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4228268/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Pulm Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2466-14-173","doi":"https://doi.org/10.1186/1471-2466-14-173","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2466-14-173","pdf_url":"https://bmcpulmmed.biomedcentral.com/counter/pdf/10.1186/1471-2466-14-173","source":{"id":"https://openalex.org/S204956882","display_name":"BMC Pulmonary Medicine","issn_l":"1471-2466","issn":["1471-2466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Pulmonary Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3424768339","display_name":"\u751f\u7269\u4ee3\u8c22\u7f51\u7edc\u878d\u5408\u9057\u4f20\u98ce\u9669\u7684\u590d\u6742\u75be\u75c5\u7279\u5f02\u4ee3\u8c22\u901a\u8def\u8bc6\u522b\u7814\u7a76","funder_award_id":"61272388","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7474787430","display_name":null,"funder_award_id":"F201237","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"},{"id":"https://openalex.org/G8611462498","display_name":null,"funder_award_id":"F201237","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2051969893.pdf","grobid_xml":"https://content.openalex.org/works/W2051969893.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W39284671","https://openalex.org/W106671516","https://openalex.org/W160195749","https://openalex.org/W1694537597","https://openalex.org/W1824824458","https://openalex.org/W1950892959","https://openalex.org/W1970090321","https://openalex.org/W1979050131","https://openalex.org/W1980064839","https://openalex.org/W1981148940","https://openalex.org/W1987943522","https://openalex.org/W1990127385","https://openalex.org/W2007843141","https://openalex.org/W2017768011","https://openalex.org/W2025112934","https://openalex.org/W2039965929","https://openalex.org/W2045392933","https://openalex.org/W2047737394","https://openalex.org/W2055446812","https://openalex.org/W2058681367","https://openalex.org/W2067827123","https://openalex.org/W2082588666","https://openalex.org/W2083301109","https://openalex.org/W2083934306","https://openalex.org/W2103087448","https://openalex.org/W2103871834","https://openalex.org/W2105864904","https://openalex.org/W2113754798","https://openalex.org/W2114554839","https://openalex.org/W2114905989","https://openalex.org/W2117263999","https://openalex.org/W2119322011","https://openalex.org/W2120999682","https://openalex.org/W2127951128","https://openalex.org/W2129119773","https://openalex.org/W2134254649","https://openalex.org/W2137349561","https://openalex.org/W2139973059","https://openalex.org/W2146533975","https://openalex.org/W2147808314","https://openalex.org/W2147815892","https://openalex.org/W2148056869","https://openalex.org/W2148764218","https://openalex.org/W2155765761","https://openalex.org/W2161633633","https://openalex.org/W2171064678","https://openalex.org/W2326175779","https://openalex.org/W3215332570","https://openalex.org/W4211263216"],"related_works":["https://openalex.org/W2047737394","https://openalex.org/W2322483957","https://openalex.org/W2004473318","https://openalex.org/W2174186300","https://openalex.org/W1994489347","https://openalex.org/W2014912219","https://openalex.org/W2349125603","https://openalex.org/W2139973059","https://openalex.org/W3030919624","https://openalex.org/W3029318287"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genetic":[1],"factors":[2],"play":[3],"a":[4,22,211],"role":[5],"in":[6,83,113,130,134,151,164,186,198],"the":[7,41,47,104,146,152,179,187,206,224,227],"development":[8],"and":[9,51,67,79,98,109,117,119,126,167,195,213,230],"severity":[10],"of":[11,19,61,69,88,106,111,115,128,132,145,189,209,226],"chronic":[12],"obstructive":[13],"pulmonary":[14,77,107],"disease":[15,153],"(COPD).":[16],"The":[17],"pathogenesis":[18,188],"COPD":[20,44,133,190],"is":[21],"multifactorial":[23],"process":[24,50,82],"including":[25],"an":[26,84,199],"inflammatory":[27,49,81],"cell":[28],"profile.":[29],"Recent":[30],"studies":[31],"revealed":[32],"that":[33,95,182],"single":[34],"nucleotide":[35],"polymorphisms":[36,63],"(SNPs)":[37],"within":[38],"ADAM33":[39,70,183],"increased":[40],"susceptibility":[42],"to":[43],"through":[45],"changing":[46],"airway":[48,80,131,173,193],"lung":[52,147],"function.":[53],"METHODS:":[54],"In":[55],"this":[56,233],"paper,":[57],"we":[58],"investigated":[59],"associations":[60],"four":[62],"(T1,":[64],"T2,":[65],"S2":[66],"Q-1)":[68],"as":[71,73],"well":[72],"their":[74],"haplotypes":[75,138,156,169],"with":[76,90,103,124,142,160,172],"function":[78,108],"East":[85,200],"Asian":[86,201],"population":[87],"patients":[89],"COPD.":[91],"RESULTS:":[92],"We":[93,176],"found":[94],"T1,":[96],"T2":[97],"Q-1":[99,120],"were":[100,121,139,157,170],"significantly":[101,122,140,158],"associated":[102,123,141,159,171],"changes":[105],"components":[110],"cells":[112],"sputum":[114],"COPD,":[116,210],"T1":[118],"cytokines":[125],"mediators":[127],"inflammation":[129,194],"recessive":[135],"models.":[136],"10":[137],"transfer":[143],"factor":[144],"for":[148,178,223,232],"carbon":[149],"monoxide":[150],"state,":[154],"4":[155],"forced":[161],"expiratory":[162],"volume":[163],"one":[165],"second,":[166],"other":[168],"inflammation.":[174],"CONCLUSIONS:":[175],"confirmed":[177],"first":[180],"time":[181],"was":[184],"involved":[185],"by":[191],"affecting":[192],"immune":[196],"response":[197],"population.":[202],"Our":[203],"results":[204],"made":[205],"genetic":[207,221],"background":[208],"common":[212],"disabling":[214],"disease,":[215],"more":[216],"apparent,":[217],"which":[218],"would":[219],"supply":[220],"support":[222],"study":[225],"mechanism,":[228],"classification":[229],"treatment":[231],"disease.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}