{"id":"https://openalex.org/W2051968667","doi":"https://doi.org/10.1117/12.17612","title":"Morphological studies of laser-induced photoacoustic damage","display_name":"Morphological studies of laser-induced photoacoustic damage","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W2051968667","doi":"https://doi.org/10.1117/12.17612","mag":"2051968667"},"language":"en","primary_location":{"id":"doi:10.1117/12.17612","doi":"https://doi.org/10.1117/12.17612","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.17612","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010963221","display_name":"Thomas James Flotte","orcid":"https://orcid.org/0000-0001-5691-8249","observed_orcids":["https://orcid.org/0000-0001-5691-8249"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Flotte","raw_affiliation_strings":["Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (USA)","Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (USA)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (United States)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047738246","display_name":"Yutaka Yashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yutaka Yashima","raw_affiliation_strings":["Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (USA)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100747348","display_name":"Shinichi Watanabe","orcid":"https://orcid.org/0000-0001-8216-9237","observed_orcids":["https://orcid.org/0000-0001-8216-9237"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Watanabe","raw_affiliation_strings":["Teikyo Univ. School of Medicine (Japan)","Teikyo University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teikyo Univ. School of Medicine (Japan)","institution_ids":["https://openalex.org/I87531838"]},{"raw_affiliation_string":"Teikyo University School of Medicine, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109187952","display_name":"Daniel J. McAuliffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. McAuliffe, Sr.","raw_affiliation_strings":["Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Labs. of Photomedicine, Harvard Medical School and Massachusetts General Hospital (USA)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029850418","display_name":"Steven L. Jacques","orcid":"https://orcid.org/0000-0001-5350-7671","observed_orcids":["https://orcid.org/0000-0001-5350-7671"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven L. Jacques","raw_affiliation_strings":["Univ. of Texas M. D. Anderson Cancer Ctr. (USA)","Univ. of Texas/M.D. Anderson Cancer Ctr. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas M. D. Anderson Cancer Ctr. (USA)","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Univ. of Texas/M.D. Anderson Cancer Ctr. (United States)","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3263,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.91629956,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"1202","issue":null,"first_page":"71","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10732","display_name":"Laser Material Processing Techniques","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10732","display_name":"Laser Material Processing Techniques","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arf-excimer-laser","display_name":"ArF excimer laser","score":0.9359999895095825},{"id":"https://openalex.org/keywords/laser-ablation","display_name":"laser ablation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/stratum-corneum","display_name":"stratum corneum","score":0.972000002861023},{"id":"https://openalex.org/keywords/skin-damage","display_name":"skin damage","score":0.5519999861717224},{"id":"https://openalex.org/keywords/shock-waves","display_name":"shock waves","score":0.5550000071525574},{"id":"https://openalex.org/keywords/pressure-transients","display_name":"pressure transients","score":0.8500000238418579},{"id":"https://openalex.org/keywords/inertial-confinement","display_name":"inertial confinement","score":0.7639999985694885},{"id":"https://openalex.org/keywords/epidermal-necrosis","display_name":"epidermal necrosis","score":0.843999981880188},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9169999957084656},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.8600000143051147},{"id":"https://openalex.org/keywords/laser-safety","display_name":"laser safety","score":0.4690000116825104},{"id":"https://openalex.org/keywords/spot-size-dependence","display_name":"spot size dependence","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.8139855265617371},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.5742047429084778},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5218609571456909},{"id":"https://openalex.org/C2779188808","wikidata":"https://www.wikidata.org/wiki/Q1806547","display_name":"Laser ablation","level":3,"score":0.4920639395713806},{"id":"https://openalex.org/C2780477314","wikidata":"https://www.wikidata.org/wiki/Q241056","display_name":"Excimer laser","level":3,"score":0.45388609170913696},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.3687208592891693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3496630787849426},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3246459364891052},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3244410753250122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1409168839454651},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09492844343185425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.17612","doi":"https://doi.org/10.1117/12.17612","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.17612","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.40070000290870667,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009794882","https://openalex.org/W2075661492","https://openalex.org/W2044458980","https://openalex.org/W2071115775","https://openalex.org/W2406494193","https://openalex.org/W2494293208","https://openalex.org/W2297134768","https://openalex.org/W2007855270","https://openalex.org/W4321264058","https://openalex.org/W1978445737"],"abstract_inverted_index":{"Argon-fluoride":[0],"excimer":[1,248],"laser":[2,249],"ablation":[3,64,71,80,94,204,250],"of":[4,88,95,126,195,246,251,298],"stratum":[5,252],"comeum":[6],"causes":[7],"deeper":[8],"tissue":[9,24],"damage":[10,51,102],"than":[11],"expected":[12],"for":[13,137,183,261],"thermal":[14],"or":[15],"photochemical":[16],"mechanisms,":[17],"suggesting":[18],"thatphotoacoustic":[19],"waves":[20],"have":[21,229,241],"arole":[22],"in":[23,118,301],"damage.":[25,152,258],"Laserirradiation":[26],"(193":[27],"nm,":[28],"14":[29],"ns":[30],"pulses,":[31],"1-2":[32],"Hz)":[33],"attworadiantexposures,":[34],"60":[35],"and":[36,45,58,99,107,141,185,198,209,232],"160":[37],"mJ/cm2perpulse":[38],"was":[39,193],"usedto":[40],"ablate":[41],"the":[42,63,70,119,124,196,203,211,262,284,295],"stratumcomeumofskin.":[43],"Light":[44],"electron":[46,187],"microscopy":[47],"ofimmediate":[48],"biopsies":[49,175],"demonstrated":[50],"to":[52,85,165,202,235,254,266,293],"fibroblasts":[53],"as":[54,56],"deep":[55],"88":[57],"220":[59],"jun,":[60],"respectively,":[61],"below":[62],"site.":[65],"Ablation":[66],"throughwaterwas":[67],"usedtoinertially":[68],"confine":[69],"zone.":[72],"Partial":[73],"ablationofs.c.":[74],"through":[75,81,97],"airproducedno":[76],"damage,":[77],"whereas":[78],"partial":[79],"water":[82,100,127],"damaged":[83],"skin":[84],"amean":[86],"depth":[87,116],"1":[89,146],"14.5":[90],"8.8(":[91],"Full":[92],"thickness":[93],"s.c.":[96],"air":[98],"produced":[101],"zones":[103],"measuring":[104],"192.2":[105],"16.2":[106],"293.0":[108],"71.6":[109],"rim,":[110],"respectively":[111],"(p":[112],"<0.05).":[113],"The":[114,134,153,214,222,259],"increased":[115],"ofdamage":[117,136],"presence":[120],"ofinertial":[121],"confinementprovided":[122],"by":[123],"layer":[125],"strongly":[128],"supports":[129],"a":[130,169,179],"photoacoustic":[131,257],"mechanism":[132],"ofdamage.":[133],"depths":[135],"thelarge":[138],"spot,":[139],"line,":[140],"small":[142],"spots":[143],"were":[144,176],"43":[145],"164":[147],"urn,":[148],"269":[149],"96xni,":[150],"andno":[151],"spot":[154],"size":[155],"dependence":[156],"ofthedepthofdamage":[157],"is":[158,233,269,291],"consistentwiththe":[159],"geometric":[160],"attenuation":[161],"one":[162],"would":[163],"expect":[164],"be":[166],"present":[167],"from":[168],"pressure":[170,267,299],"wave":[171],"related":[172],"phenomena.":[173],"Sequential":[174],"taken":[177],"over":[178],"7":[180],"day":[181],"period":[182],"light":[184],"transmission":[186],"microscopy.":[188],"At":[189],"24":[190],"hours,":[191],"there":[192],"necrosis":[194],"epidermis":[197],"papillary":[199],"dermis":[200],"subjacent":[201],"site,":[205],"with":[206],"neutrophils":[207],"surrounding":[208],"demarcating":[210],"affected":[212],"area.":[213],"necrotic":[215],"zone":[216],"sloughedby48":[217],"hours.":[218],"Thereepithelializationwas":[219],"completeby7":[220],"days.":[221],"sequenceofrepairis":[223],"similartoknife":[224],"wound":[225,237],"healing":[226,238],"which":[227],"we":[228],"previously":[230],"studied,":[231],"analogous":[234],"other":[236],"processes.":[239],"We":[240],"used":[242],"an":[243],"experimental":[244],"model":[245],"ArF":[247],"corneum":[253],"investigate":[255],"laser-induced":[256],"evidence":[260],"injury":[263],"being":[264],"due":[265],"transients":[268,276,300],"indirectbutcompelling.":[270],"Whether":[271],"these":[272,288],"pressuretransients":[273],"are":[274,283],"acoustic":[275],"orshockwaves":[277],"has":[278],"notbeendetermined,":[279],"although":[280],"itis":[281],"ourprejudicethatshockwaves":[282],"predominant":[285],"force":[286],"under":[287],"conditions.":[289],"It":[290],"important":[292],"consider":[294],"possible":[296],"effects":[297],"evaluating":[302],"laser-tissue":[303],"interactions,":[304],"particularly":[305],"when":[306],"using":[307],"short":[308],"pulse,":[309],"high":[310],"peak":[311],"power":[312],"lasers.":[313]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}