{"id":"https://openalex.org/W2051963301","doi":"https://doi.org/10.1016/j.nano.2015.01.017","title":"Conformation-dependent binding and tumor-targeted delivery of siRNA by a designed TRBP2: Affibody fusion protein","display_name":"Conformation-dependent binding and tumor-targeted delivery of siRNA by a designed TRBP2: Affibody fusion protein","publication_year":2015,"publication_date":"2015-02-23","ids":{"openalex":"https://openalex.org/W2051963301","doi":"https://doi.org/10.1016/j.nano.2015.01.017","mag":"2051963301","pmid":"https://pubmed.ncbi.nlm.nih.gov/25720988"},"language":"en","primary_location":{"id":"doi:10.1016/j.nano.2015.01.017","doi":"https://doi.org/10.1016/j.nano.2015.01.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nano.2015.01.017","pdf_url":null,"source":{"id":"https://openalex.org/S80729884","display_name":"Nanomedicine Nanotechnology Biology and Medicine","issn_l":"1549-9634","issn":["1549-9634","1549-9642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine: Nanotechnology, Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109450869","display_name":"Ghulam Hassan Dar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ghulam Hassan Dar","raw_affiliation_strings":["CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India","institution_ids":["https://openalex.org/I185638415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024210369","display_name":"Vijaya Gopal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vijaya Gopal","raw_affiliation_strings":["CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Electronic address: vijaya@ccmb.res.in","CSIR-Centre for Cellular and Molecular Biology Hyderabad India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Electronic address: vijaya@ccmb.res.in","institution_ids":["https://openalex.org/I185638415"]},{"raw_affiliation_string":"CSIR-Centre for Cellular and Molecular Biology Hyderabad India","institution_ids":["https://openalex.org/I185638415"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109164256","display_name":"Madhusudhana Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185638415","display_name":"Centre for Cellular and Molecular Biology","ror":"https://ror.org/05shq4n12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185638415","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Madhusudhana Rao","raw_affiliation_strings":["CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Electronic address: madhu@ccmb.res.in","CSIR-Centre for Cellular and Molecular Biology Hyderabad India"],"raw_orcid":"https://orcid.org/0000-0002-4308-4924","affiliations":[{"raw_affiliation_string":"CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Electronic address: madhu@ccmb.res.in","institution_ids":["https://openalex.org/I185638415"]},{"raw_affiliation_string":"CSIR-Centre for Cellular and Molecular Biology Hyderabad India","institution_ids":["https://openalex.org/I185638415"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024210369","https://openalex.org/A5109164256"],"corresponding_institution_ids":["https://openalex.org/I185638415"],"apc_list":{"value":3670,"currency":"USD","value_usd":3670},"apc_paid":null,"fwci":0.6922,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.65946697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"6","first_page":"1455","last_page":"1466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9919999837875366},{"id":"https://openalex.org/keywords/affibody","display_name":"affibody","score":0.9179999828338623},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.8140000104904175},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.3700000047683716},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.656000018119812},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7480000257492065},{"id":"https://openalex.org/keywords/aurora-b-kinase","display_name":"Aurora B kinase","score":0.6919999718666077},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.5860000252723694},{"id":"https://openalex.org/keywords/engineered-proteins","display_name":"engineered proteins","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.6986526250839233},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6803429126739502},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.6282708644866943},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.5806024074554443},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.500953197479248},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.47782114148139954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4749320149421692},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.4501400887966156},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.44562777876853943},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.4274865984916687},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3967130184173584},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.38237476348876953},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3791190981864929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2949676811695099},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24595168232917786},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24111157655715942},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12218108773231506},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.07933488488197327}],"mesh":[{"descriptor_ui":"D000099253","descriptor_name":"Trans-Activation Responsive RNA-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018734","descriptor_name":"Genes, erbB-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064107","descriptor_name":"Aurora Kinase B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.nano.2015.01.017","doi":"https://doi.org/10.1016/j.nano.2015.01.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nano.2015.01.017","pdf_url":null,"source":{"id":"https://openalex.org/S80729884","display_name":"Nanomedicine Nanotechnology Biology and Medicine","issn_l":"1549-9634","issn":["1549-9634","1549-9642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine: Nanotechnology, Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:25720988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25720988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomedicine : nanotechnology, biology, and medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W268839726","https://openalex.org/W1759643083","https://openalex.org/W1860382351","https://openalex.org/W1939154811","https://openalex.org/W1966660791","https://openalex.org/W1971601502","https://openalex.org/W1974024530","https://openalex.org/W1975647360","https://openalex.org/W1976060898","https://openalex.org/W1980577287","https://openalex.org/W1981127040","https://openalex.org/W1986206869","https://openalex.org/W1988118133","https://openalex.org/W1993804787","https://openalex.org/W1994296373","https://openalex.org/W1995326731","https://openalex.org/W2005570679","https://openalex.org/W2006724257","https://openalex.org/W2009707750","https://openalex.org/W2011209045","https://openalex.org/W2015175027","https://openalex.org/W2022956379","https://openalex.org/W2025722048","https://openalex.org/W2025938842","https://openalex.org/W2026523172","https://openalex.org/W2029842408","https://openalex.org/W2035950274","https://openalex.org/W2036752075","https://openalex.org/W2038660811","https://openalex.org/W2040415740","https://openalex.org/W2041687573","https://openalex.org/W2045840002","https://openalex.org/W2047165821","https://openalex.org/W2049233124","https://openalex.org/W2053626384","https://openalex.org/W2059991035","https://openalex.org/W2070280888","https://openalex.org/W2070693578","https://openalex.org/W2072599666","https://openalex.org/W2082421311","https://openalex.org/W2084621409","https://openalex.org/W2095295884","https://openalex.org/W2111693820","https://openalex.org/W2120085804","https://openalex.org/W2122426644","https://openalex.org/W2124018243","https://openalex.org/W2126163864","https://openalex.org/W2134444723","https://openalex.org/W2134450909","https://openalex.org/W2138024261","https://openalex.org/W2143826011","https://openalex.org/W2159727405"],"related_works":["https://openalex.org/W2078847302","https://openalex.org/W3199619449","https://openalex.org/W2323587120","https://openalex.org/W2012178961","https://openalex.org/W4402836980","https://openalex.org/W2098113504","https://openalex.org/W2620836871","https://openalex.org/W234058275","https://openalex.org/W2312707258","https://openalex.org/W4243480284"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
