{"id":"https://openalex.org/W205196154","doi":"https://doi.org/10.1042/bj2210021","title":"Expression of myosin isoenzymes in cardiac-muscle cells in culture","display_name":"Expression of myosin isoenzymes in cardiac-muscle cells in culture","publication_year":1984,"publication_date":"1984-07-01","ids":{"openalex":"https://openalex.org/W205196154","doi":"https://doi.org/10.1042/bj2210021","mag":"205196154","pmid":"https://pubmed.ncbi.nlm.nih.gov/6235805","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1143998"},"language":"en","primary_location":{"id":"doi:10.1042/bj2210021","doi":"https://doi.org/10.1042/bj2210021","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2210021","pdf_url":"https://portlandpress.com/biochemj/article-pdf/221/1/21/581843/bj2210021.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/221/1/21/581843/bj2210021.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110125640","display_name":"Asish C. Nag","orcid":"https://orcid.org/0009-0008-1790-597X","observed_orcids":["https://orcid.org/0009-0008-1790-597X"]},"institutions":[{"id":"https://openalex.org/I177721651","display_name":"Oakland University","ror":"https://ror.org/01ythxj32","country_code":"US","type":"education","lineage":["https://openalex.org/I177721651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A C Nag","raw_affiliation_strings":["Department of Biological Sciences, Oakland University, Rochester, MI 48063, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Oakland University, Rochester, MI 48063, U.S.A","institution_ids":["https://openalex.org/I177721651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003922381","display_name":"Ming Y. Cheng","orcid":"https://orcid.org/0000-0002-1742-7022","observed_orcids":["https://orcid.org/0000-0002-1742-7022"]},"institutions":[{"id":"https://openalex.org/I177721651","display_name":"Oakland University","ror":"https://ror.org/01ythxj32","country_code":"US","type":"education","lineage":["https://openalex.org/I177721651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Cheng","raw_affiliation_strings":["Department of Biological Sciences, Oakland University, Rochester, MI 48063, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Oakland University, Rochester, MI 48063, U.S.A","institution_ids":["https://openalex.org/I177721651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177721651"],"apc_list":null,"apc_paid":null,"fwci":3.0579,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.90308112,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"221","issue":"1","first_page":"21","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myosin-isozymes","display_name":"myosin isoenzymes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cardiac-differentiation","display_name":"cardiac differentiation","score":0.4950000047683716},{"id":"https://openalex.org/keywords/cardiac-growth","display_name":"cardiac growth","score":0.35499998927116394},{"id":"https://openalex.org/keywords/fetal-to-adult-transition","display_name":"fetal to adult transition","score":0.640999972820282},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6000000238418579},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.7009999752044678},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.8715546131134033},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.7974862456321716},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.7232468128204346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6775294542312622},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5286279916763306},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4781566560268402},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.45932552218437195},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4365256428718567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3377765119075775},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3005332350730896},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2966715693473816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0852765142917633},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05987641215324402}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj2210021","doi":"https://doi.org/10.1042/bj2210021","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2210021","pdf_url":"https://portlandpress.com/biochemj/article-pdf/221/1/21/581843/bj2210021.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1143998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1143998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:6235805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6235805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj2210021","doi":"https://doi.org/10.1042/bj2210021","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2210021","pdf_url":"https://portlandpress.com/biochemj/article-pdf/221/1/21/581843/bj2210021.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309272","display_name":"Wayne State University","ror":"https://ror.org/01070mq45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W205196154.pdf","grobid_xml":"https://content.openalex.org/works/W205196154.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W188357701","https://openalex.org/W1481753986","https://openalex.org/W1511834042","https://openalex.org/W1513388062","https://openalex.org/W1775749144","https://openalex.org/W1968564818","https://openalex.org/W1983511446","https://openalex.org/W1989400140","https://openalex.org/W1995304776","https://openalex.org/W2005049338","https://openalex.org/W2014295657","https://openalex.org/W2049983113","https://openalex.org/W2051146620","https://openalex.org/W2051760356","https://openalex.org/W2055373646","https://openalex.org/W2080614311","https://openalex.org/W2088299673","https://openalex.org/W2093297854","https://openalex.org/W2102923578","https://openalex.org/W2119528854","https://openalex.org/W2121927711","https://openalex.org/W2146367064","https://openalex.org/W2406885936","https://openalex.org/W2407984667","https://openalex.org/W2417393887","https://openalex.org/W6606164797","https://openalex.org/W6757604531","https://openalex.org/W6823655326"],"related_works":["https://openalex.org/W2014901818","https://openalex.org/W2096116740","https://openalex.org/W2091005514","https://openalex.org/W2127546896","https://openalex.org/W2410979754","https://openalex.org/W2077807749","https://openalex.org/W2051410370","https://openalex.org/W2065827478","https://openalex.org/W3148083893","https://openalex.org/W2126522809"],"abstract_inverted_index":{"Myosin":[0],"isoenzyme":[1,42,58,67,124,135,155,181,186,216,223,241,265],"profiles":[2,59,125,242],"of":[3,23,29,48,69,76,86,120,126,141,160,179,185,199,212,222,230,239,258],"rat":[4,91,190,231,245],"and":[5,14,21,46,89,148],"chicken":[6,214],"embryonic":[7,103],"cardiac":[8,104,246,275],"myocytes":[9,34,105,150,191,247,276],"were":[10,106],"studied":[11],"during":[12],"differentiation":[13],"growth":[15],"in":[16,38,63,79,108,113,188,201,243,254,272],"vitro":[17,109],"by":[18],"native-gel":[19],"electrophoresis":[20],"assay":[22],"Ca2+-activated":[24],"ATPase.":[25],"The":[26,143],"electrophoretic":[27,177],"pattern":[28,165],"myosin":[30,123,154,215,240],"extracted":[31],"from":[32,60,74,84],"18-day-embryonic-rat":[33],"after":[35,138,157],"7":[36,111,158],"days":[37,112,159],"culture":[39,72,161],"exhibits":[40],"three":[41],"bands,":[43],"V1,":[44,224],"V2":[45],"V3,":[47],"which":[49],"the":[50,57,66,70,87,93,97,131,164,168,176,202,213,237,252,262,268],"slow-migrating":[51],"V3":[52,266],"is":[53,217,226],"predominant.":[54],"This":[55,206,233],"resembles":[56,163],"18-20-day-embryonic":[61],"ventricles":[62,147],"vivo.":[64,255],"However,":[65],"profile":[68],"7-day-old":[71,144],"differs":[73],"that":[75,85,162,198,209,221,229,236],"its":[77],"counterpart":[78],"vivo,":[80],"as":[81,83],"well":[82],"young":[88],"adult":[90,132,169,204,269],"ventricles,":[92],"last":[94],"two":[95],"containing":[96,116],"predominant":[98,263],"fast-migrating":[99],"component,":[100],"V1.":[101],"When":[102],"grown":[107],"for":[110,167],"a":[114,117,152,278],"medium":[115],"physiological":[118],"concentration":[119],"L-thyroxine":[121],"(T4),":[122],"these":[127],"cells":[128],"shifted":[129],"to":[130,267],"form,":[133],"with":[134,193,197,228],"V1":[136,187,200,271],"predominating":[137],"day":[139],"4":[140],"culture.":[142],"intact":[145],"embryonic-chicken":[146],"isolated":[149],"showed":[151],"single":[153],"band":[156],"seen":[166],"chicken.":[170],"T4":[171,194,259],"had":[172],"no":[173],"effect":[174],"on":[175],"mobility":[178],"this":[180],"pattern.":[182],"ATPase":[183,210],"activity":[184,211],"cultured":[189,244,273],"treated":[192],"was":[195],"comparable":[196,227],"untreated":[203],"heart.":[205],"study":[207,234],"demonstrates":[208],"significantly":[218],"lower":[219],"than":[220],"but":[225],"V3.":[232],"shows":[235],"expression":[238],"does":[248],"not":[249],"fully":[250],"represent":[251],"situation":[253],"Physiological":[256],"concentrations":[257],"can":[260],"modulate":[261],"foetal-type":[264],"type":[270],"embryonic-rat":[274],"within":[277],"brief":[279],"period.":[280]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}