{"id":"https://openalex.org/W2051948569","doi":"https://doi.org/10.1097/mnh.0b013e328362483a","title":"Clinical assessment of phosphorus status, balance and renal handling in normal individuals and in patients with chronic kidney disease","display_name":"Clinical assessment of phosphorus status, balance and renal handling in normal individuals and in patients with chronic kidney disease","publication_year":2013,"publication_date":"2013-05-16","ids":{"openalex":"https://openalex.org/W2051948569","doi":"https://doi.org/10.1097/mnh.0b013e328362483a","mag":"2051948569","pmid":"https://pubmed.ncbi.nlm.nih.gov/23680649"},"language":"en","primary_location":{"id":"doi:10.1097/mnh.0b013e328362483a","doi":"https://doi.org/10.1097/mnh.0b013e328362483a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mnh.0b013e328362483a","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology & Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080225643","display_name":"Chou-Long Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chou-Long Huang","raw_affiliation_strings":["Department of Internal Medicine, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas 75390-8856, USA. chou-long.huang@utsouthwestern.edu","Charles and Jane Pak Center of Mineral Metabolism, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas, USA","Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas 75390-8856, USA. chou-long.huang@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Charles and Jane Pak Center of Mineral Metabolism, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023488815","display_name":"Orson W. Moe","orcid":"https://orcid.org/0000-0001-9176-3414","observed_orcids":["https://orcid.org/0000-0001-9176-3414"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orson W. Moe","raw_affiliation_strings":["Charles and Jane Pak Center of Mineral Metabolism, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas, USA","Department of Internal Medicine","Department of Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles and Jane Pak Center of Mineral Metabolism, Clinical Research University of Texas, Southwestern Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080225643"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":0.7095,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73272933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"4","first_page":"452","last_page":"458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphorus-status","display_name":"phosphorus status","score":0.8870000243186951},{"id":"https://openalex.org/keywords/phosphorus-balance","display_name":"phosphorus balance","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mineral-metabolism-disorders","display_name":"mineral metabolism disorders","score":0.6389999985694885},{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.8830000162124634},{"id":"https://openalex.org/keywords/phosphaturia","display_name":"phosphaturia","score":0.6779999732971191},{"id":"https://openalex.org/keywords/plasma-phosphorus","display_name":"plasma phosphorus","score":0.5699999928474426},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2776036575","wikidata":"https://www.wikidata.org/wiki/Q1641062","display_name":"Hyperphosphatemia","level":3,"score":0.7683029174804688},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6600927710533142},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6274974346160889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6243266463279724},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5590154528617859},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33735448122024536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26534396409988403}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010760","descriptor_name":"Phosphorus Metabolism Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010760","descriptor_name":"Phosphorus Metabolism Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010760","descriptor_name":"Phosphorus Metabolism Disorders","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010760","descriptor_name":"Phosphorus Metabolism Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mnh.0b013e328362483a","doi":"https://doi.org/10.1097/mnh.0b013e328362483a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mnh.0b013e328362483a","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology & Hypertension","raw_type":"journal-article"},{"id":"pmid:23680649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23680649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in nephrology and hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6350086866","display_name":"Klotho and Phosphate in Chronic Kidney Disease: Pathogenesis and Therapeutics","funder_award_id":"R01DK091392","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6841593247","display_name":"Klotho: Therapeutic Agent for Ischemia Reperfusion Induced Acute Kidney Injury","funder_award_id":"R01DK092461","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7496888697","display_name":"Membrane Trafficking of Renal Ion Transport Proteins in Potassium Homeostasis","funder_award_id":"R01DK059530","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7584882416","display_name":"UT Southwestern O'Brien Kidney Research Core Center","funder_award_id":"P30DK079328","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7888050461","display_name":"Regulation of renal calcium transport","funder_award_id":"R01DK085726","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1563425273","https://openalex.org/W1870160655","https://openalex.org/W1963666197","https://openalex.org/W1978205472","https://openalex.org/W1985853322","https://openalex.org/W1996731541","https://openalex.org/W2002210641","https://openalex.org/W2022911715","https://openalex.org/W2037793712","https://openalex.org/W2041923673","https://openalex.org/W2051959338","https://openalex.org/W2055157703","https://openalex.org/W2059038646","https://openalex.org/W2064761203","https://openalex.org/W2078730571","https://openalex.org/W2084236320","https://openalex.org/W2094551185","https://openalex.org/W2101491452","https://openalex.org/W2110023205","https://openalex.org/W2110404756","https://openalex.org/W2129321769","https://openalex.org/W2133871797","https://openalex.org/W2137591192","https://openalex.org/W2152109784","https://openalex.org/W2156191150","https://openalex.org/W2158876277","https://openalex.org/W2171100097","https://openalex.org/W2415954208","https://openalex.org/W4211105878"],"related_works":["https://openalex.org/W2413715188","https://openalex.org/W150518949","https://openalex.org/W2366181520","https://openalex.org/W1573031619","https://openalex.org/W2760998711","https://openalex.org/W2618610295","https://openalex.org/W2131952235","https://openalex.org/W2884907261","https://openalex.org/W4403595468","https://openalex.org/W87884298"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"The":[3,26,48,137],"concepts":[4,58],"of":[5,33,50,63,132,140,166,175],"steady":[6],"state,":[7],"external":[8],"balance,":[9],"total":[10],"body":[11],"status":[12],"and":[13,36,59,76,91,127,135,142,145,193,199,202],"internal":[14],"distribution":[15],"are":[16,38,98,187],"not":[17,188],"always":[18],"appreciated":[19],"or":[20],"even":[21,109],"considered":[22],"in":[23,40,83,93,110,173,183],"clinical":[24,31,185],"practice.":[25],"current":[27,180],"tests":[28,67,182],"available":[29,66,181],"for":[30],"assessment":[32],"phosphorus":[34,70,133,176],"physiology":[35],"pathophysiology":[37],"valid":[39],"some":[41],"aspects,":[42],"but":[43],"also":[44,99],"have":[45,79],"many":[46],"limitations.":[47],"purpose":[49],"this":[51],"review":[52],"is":[53,122,128,159],"to":[54,68,88,163,204],"clarify":[55],"the":[56,61,64,89,103,179,184],"above":[57],"discuss":[60],"utility":[62],"currently":[65],"assess":[69],"disorders.":[71],"RECENT":[72],"FINDINGS:":[73],"Both":[74],"epidemiologic":[75],"preclinical":[77],"data":[78,101],"shown":[80],"that":[81,105],"disturbances":[82],"mineral":[84],"metabolism":[85],"contribute":[86],"significantly":[87],"morbidity":[90],"mortality":[92],"chronic":[94,117],"kidney":[95,118],"disease.":[96],"There":[97,158],"emerging":[100],"supporting":[102],"notion":[104],"phosphotoxicity":[106],"may":[107],"exist":[108],"individuals":[111],"with":[112],"normal":[113],"renal":[114],"function.":[115],"In":[116],"disease":[119],"(CKD),":[120],"hyperphosphatemia":[121],"a":[123,129,160],"relative":[124],"late":[125],"event":[126],"suboptimal":[130],"indicator":[131],"balance":[134],"status.":[136],"judicious":[138],"use":[139],"plasma":[141],"urine":[143],"chemistry":[144],"hormonal":[146],"biomarkers":[147],"such":[148],"as":[149],"fibroblast":[150],"growth":[151],"factor":[152],"23":[153],"should":[154,170],"be":[155,171],"considered.":[156],"SUMMARY:":[157],"dire":[161],"need":[162],"increase":[164],"awareness":[165],"what":[167],"physiologic":[168],"parameters":[169],"monitored":[172],"terms":[174],"pathophysiology.":[177],"Although":[178],"armamentarium":[186],"ideal,":[189],"understanding":[190],"their":[191],"implications":[192],"limitations":[194],"will":[195],"improve":[196],"patient":[197],"care":[198],"motivate":[200],"practitioners":[201],"investigators":[203],"develop":[205],"better":[206],"tests.":[207]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}