{"id":"https://openalex.org/W2051931549","doi":"https://doi.org/10.1002/acn3.26","title":"LRP 4 antibodies in serum and CSF from amyotrophic lateral sclerosis patients","display_name":"LRP 4 antibodies in serum and CSF from amyotrophic lateral sclerosis patients","publication_year":2013,"publication_date":"2013-12-30","ids":{"openalex":"https://openalex.org/W2051931549","doi":"https://doi.org/10.1002/acn3.26","mag":"2051931549","pmid":"https://pubmed.ncbi.nlm.nih.gov/25356387"},"language":"en","primary_location":{"id":"doi:10.1002/acn3.26","doi":"https://doi.org/10.1002/acn3.26","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.26","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.26","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057055044","display_name":"John S. Tzartos","orcid":"https://orcid.org/0000-0002-8153-5300","observed_orcids":["https://orcid.org/0000-0002-8153-5300","https://orcid.org/0000-0001-7948-034X"]},"institutions":[{"id":"https://openalex.org/I4210099086","display_name":"Hellenic Red Cross","ror":"https://ror.org/00zzcmy73","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210099086"]},{"id":"https://openalex.org/I4210100614","display_name":"Red Cross Hospital","ror":"https://ror.org/00nnh8h94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210100614"]},{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"John S. Tzartos","raw_affiliation_strings":["Department of Neurology General Hospital \u201cRed Cross\u201d Athens Greece","Hellenic Pasteur Institute Athens Greece","Department of Neurology, General Hospital \"Red Cross\", Athens, Greece","Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology General Hospital \u201cRed Cross\u201d Athens Greece","institution_ids":["https://openalex.org/I4210099086","https://openalex.org/I4210100614"]},{"raw_affiliation_string":"Hellenic Pasteur Institute Athens Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"Department of Neurology, General Hospital \"Red Cross\", Athens, Greece","institution_ids":["https://openalex.org/I4210099086","https://openalex.org/I4210100614"]},{"raw_affiliation_string":"Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065597455","display_name":"Paraskevi Zisimopoulou","orcid":"https://orcid.org/0000-0003-1248-4869","observed_orcids":["https://orcid.org/0000-0003-1248-4869"]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Paraskevi Zisimopoulou","raw_affiliation_strings":["Hellenic Pasteur Institute Athens Greece","Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Pasteur Institute Athens Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111421963","display_name":"Michael Rentzos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Michael Rentzos","raw_affiliation_strings":["Neurology Department Aeginition Hospital School of Medicine National and Kapodistrian University Athens Greece","Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department Aeginition Hospital School of Medicine National and Kapodistrian University Athens Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210141397"]},{"raw_affiliation_string":"Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210141397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112133516","display_name":"Nikos Karandreas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikos Karandreas","raw_affiliation_strings":["Neurology Department Aeginition Hospital School of Medicine National and Kapodistrian University Athens Greece","Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department Aeginition Hospital School of Medicine National and Kapodistrian University Athens Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210141397"]},{"raw_affiliation_string":"Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210141397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019515396","display_name":"Vasiliki Zouvelou","orcid":"https://orcid.org/0000-0002-4652-3582","observed_orcids":["https://orcid.org/0000-0002-4652-3582"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasiliki Zouvelou","raw_affiliation_strings":["Neurology Department Aeginition Hospital School of Medicine National and Kapodistrian University Athens Greece","Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department Aeginition Hospital School of Medicine National and Kapodistrian University Athens Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210141397"]},{"raw_affiliation_string":"Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210141397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041672398","display_name":"Panagiota Evangelakou","orcid":"https://orcid.org/0000-0001-7349-0344","observed_orcids":["https://orcid.org/0000-0001-7349-0344"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiota Evangelakou","raw_affiliation_strings":["Department of Pharmacy University of Patras Patras Greece","Hellenic Pasteur Institute Athens Greece","Department of Pharmacy, University of Patras, Patras, Greece","Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy University of Patras Patras Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Hellenic Pasteur Institute Athens Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"Department of Pharmacy, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017283013","display_name":"Anastasios Tsonis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]},{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasios Tsonis","raw_affiliation_strings":["Department of Pharmacy University of Patras Patras Greece","Hellenic Pasteur Institute Athens Greece","Department of Pharmacy, University of Patras, Patras, Greece","Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy University of Patras Patras Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Hellenic Pasteur Institute Athens Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"Department of Pharmacy, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064675260","display_name":"T. Thomaides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099086","display_name":"Hellenic Red Cross","ror":"https://ror.org/00zzcmy73","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210099086"]},{"id":"https://openalex.org/I4210100614","display_name":"Red Cross Hospital","ror":"https://ror.org/00nnh8h94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210100614"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Thomas Thomaidis","raw_affiliation_strings":["Department of Neurology General Hospital \u201cRed Cross\u201d Athens Greece","Department of Neurology, General Hospital \"Red Cross\", Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology General Hospital \u201cRed Cross\u201d Athens Greece","institution_ids":["https://openalex.org/I4210099086","https://openalex.org/I4210100614"]},{"raw_affiliation_string":"Department of Neurology, General Hospital \"Red Cross\", Athens, Greece","institution_ids":["https://openalex.org/I4210099086","https://openalex.org/I4210100614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041994767","display_name":"Giuseppe Lauria","orcid":"https://orcid.org/0000-0001-9773-020X","observed_orcids":["https://orcid.org/0000-0001-9773-020X","https://orcid.org/0000-0002-0225-6136"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Lauria","raw_affiliation_strings":["Neurological Institute \u201cCarlo Besta\u201d Milano Italy","Neurological Institute \"Carlo Besta\", Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Institute \u201cCarlo Besta\u201d Milano Italy","institution_ids":["https://openalex.org/I4210164485"]},{"raw_affiliation_string":"Neurological Institute \"Carlo Besta\", Milano, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073287634","display_name":"Francesca Andreetta","orcid":"https://orcid.org/0000-0001-8239-8830","observed_orcids":["https://orcid.org/0000-0001-8239-8830"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Andreetta","raw_affiliation_strings":["Neurological Institute \u201cCarlo Besta\u201d Milano Italy","Neurological Institute \"Carlo Besta\", Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Institute \u201cCarlo Besta\u201d Milano Italy","institution_ids":["https://openalex.org/I4210164485"]},{"raw_affiliation_string":"Neurological Institute \"Carlo Besta\", Milano, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032850040","display_name":"Renato Mantegazza","orcid":"https://orcid.org/0000-0002-9810-5737","observed_orcids":["https://orcid.org/0000-0002-9810-5737"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renato Mantegazza","raw_affiliation_strings":["Neurological Institute \u201cCarlo Besta\u201d Milano Italy","Neurological Institute \"Carlo Besta\", Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Institute \u201cCarlo Besta\u201d Milano Italy","institution_ids":["https://openalex.org/I4210164485"]},{"raw_affiliation_string":"Neurological Institute \"Carlo Besta\", Milano, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023493839","display_name":"Socrates J. Tzartos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]},{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Socrates J. Tzartos","raw_affiliation_strings":["Hellenic Pasteur Institute Athens Greece","Neurology Department Aeginition Hospital School of Medicine National and Kapodistrian University Athens Greece","Hellenic Pasteur Institute, Athens, Greece","Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hellenic Pasteur Institute Athens Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"Neurology Department Aeginition Hospital School of Medicine National and Kapodistrian University Athens Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210141397"]},{"raw_affiliation_string":"Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]},{"raw_affiliation_string":"Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210141397"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5023493839"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210123780","https://openalex.org/I4210141397"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":4.3686,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.9468553,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"2","first_page":"80","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/lrp4","display_name":"LRP4","score":0.9269999861717224},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8550000190734863},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.8740000128746033},{"id":"https://openalex.org/keywords/motor-neuron-degeneration","display_name":"motor neuron degeneration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/myasthenia-gravis","display_name":"myasthenia gravis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/denervation","display_name":"denervation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.9312438368797302},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8470975160598755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7622846364974976},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.6128250360488892},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5970894694328308},{"id":"https://openalex.org/C2777240379","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular junction","level":2,"score":0.5869941115379333},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.5283967852592468},{"id":"https://openalex.org/C2777373429","wikidata":"https://www.wikidata.org/wiki/Q3916640","display_name":"Lower motor neuron","level":4,"score":0.49592217803001404},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4027728736400604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32127243280410767},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.160150408744812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12045687437057495},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11665880680084229}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/acn3.26","doi":"https://doi.org/10.1002/acn3.26","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.26","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.26","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},{"id":"pmid:25356387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25356387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and translational neurology","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/530258","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/530258","pdf_url":"https://air.unimi.it/bitstream/2434/530258/2/LRP4%20ALS.pdf","source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4212481","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4212481","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ann Clin Transl Neurol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/acn3.26","doi":"https://doi.org/10.1002/acn3.26","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.26","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.26","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338351","display_name":"FP7 Research Potential of Convergence Regions","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2051931549.pdf","grobid_xml":"https://content.openalex.org/works/W2051931549.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1963748908","https://openalex.org/W1963853740","https://openalex.org/W1987262253","https://openalex.org/W1998975866","https://openalex.org/W2000220126","https://openalex.org/W2001765460","https://openalex.org/W2012006815","https://openalex.org/W2015468967","https://openalex.org/W2016232398","https://openalex.org/W2016462453","https://openalex.org/W2032288008","https://openalex.org/W2043459401","https://openalex.org/W2070720564","https://openalex.org/W2074062157","https://openalex.org/W2085717208","https://openalex.org/W2102593255","https://openalex.org/W2111470622","https://openalex.org/W2111821994","https://openalex.org/W2144696840","https://openalex.org/W2153504354","https://openalex.org/W2154415802","https://openalex.org/W2156236044","https://openalex.org/W2156431312","https://openalex.org/W2165204417","https://openalex.org/W2166801561","https://openalex.org/W2330098592","https://openalex.org/W2417626225"],"related_works":["https://openalex.org/W1835962715","https://openalex.org/W2772074919","https://openalex.org/W2058688785","https://openalex.org/W3005771570","https://openalex.org/W2921710618","https://openalex.org/W4230768211","https://openalex.org/W1568055891","https://openalex.org/W2507682763","https://openalex.org/W4206162425","https://openalex.org/W4206749202"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Amyotrophic":[1],"lateral":[2],"sclerosis":[3],"(ALS)":[4],"and":[5,16,30,35,37,71,74,100,115,161,199],"myasthenia":[6],"gravis":[7],"(MG)":[8],"are":[9,189,200],"caused,":[10],"respectively,":[11],"by":[12,220],"motor":[13,33,54],"neuron":[14,55],"degeneration":[15],"neuromuscular":[17],"junction":[18],"(NMJ)":[19],"dysfunction.":[20],"The":[21,121],"membrane":[22],"protein":[23],"LRP4":[24,38,60,86,124,147,181,187,210],"is":[25],"crucial":[26],"in":[27,44,53,62,90,105,126,165,170,191,204,218,222],"the":[28,50,79,223],"development":[29],"function":[31,56],"of":[32,49,123,128,144],"neurons":[34],"NMJs":[36],"autoantibodies":[39,87,125,155,188],"have":[40,213],"been":[41],"recently":[42],"detected":[43,89,164],"some":[45],"MG":[46,158,208],"patients.":[47,64,84,167,209],"Because":[48],"critical":[51],"role":[52],"we":[57,77],"searched":[58],"for":[59,134],"antibodies":[61,211],"ALS":[63,83,95,149,166,176,205,219],"METHODS:":[65],"We":[66,184],"developed":[67],"a":[68,72,214],"cell-based":[69],"assay":[70],"radioimmunoassay":[73],"with":[75,111,178,193],"these":[76],"studied":[78],"sera":[80,91,108,117],"from":[81,92,97,109,118,142],"104":[82],"RESULTS:":[85],"were":[88,151,163,173],"24/104":[93],"(23.4%)":[94],"patients":[96,110,131,150,177,192,206],"Greece":[98],"(12/51)":[99],"Italy":[101],"(12/53),":[102],"but":[103],"only":[104],"5/138":[106],"(3.6%)":[107],"other":[112,157],"neurological":[113,194],"diseases":[114],"0/40":[116],"healthy":[119],"controls.":[120],"presence":[122],"five":[127],"six":[129,143],"tested":[130,146],"was":[132],"persistent":[133],"at":[135],"least":[136],"10":[137],"months.":[138],"Cerebrospinal":[139],"fluid":[140],"samples":[141],"seven":[145],"antibody-seropositive":[148],"also":[152],"positive.":[153],"No":[154,168],"to":[156],"autoantigens":[159],"(AChR":[160],"MuSK)":[162],"differences":[169],"clinical":[171],"pattern":[172],"seen":[174],"between":[175],"or":[179],"without":[180],"antibodies.":[182],"CONCLUSIONS:":[183],"infer":[185],"that":[186],"involved":[190],"manifestations":[195],"affecting":[196],"LRP4-containing":[197],"tissues":[198],"found":[201],"more":[202],"frequently":[203],"than":[207],"may":[212],"direct":[215],"pathogenic":[216],"activity":[217],"participating":[221],"denervation":[224],"process.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
