{"id":"https://openalex.org/W2051919738","doi":"https://doi.org/10.1016/0735-1097(95)91980-c","title":"723-1 Selective Reduction of Heart Rate with the Sinus Node Inhibitor Zatebradine (ULFS 49) Does not Lead to the Expected Improvements in Exercise Duration in Patients with Angina Pectoris","display_name":"723-1 Selective Reduction of Heart Rate with the Sinus Node Inhibitor Zatebradine (ULFS 49) Does not Lead to the Expected Improvements in Exercise Duration in Patients with Angina Pectoris","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2051919738","doi":"https://doi.org/10.1016/0735-1097(95)91980-c","mag":"2051919738"},"language":"en","primary_location":{"id":"doi:10.1016/0735-1097(95)91980-c","doi":"https://doi.org/10.1016/0735-1097(95)91980-c","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0735-1097(95)91980-c","pdf_url":"https://www.sciencedirect.com/science/article/pii/073510979591980C/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/073510979591980C/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012896101","display_name":"Stephen P. Glasser","orcid":"https://orcid.org/0000-0001-9620-6406","observed_orcids":["https://orcid.org/0000-0001-9620-6406"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen P. Glasser","raw_affiliation_strings":["University of South Florida, Tampa, FL","Univ. of South Florida, Tampa, Fl.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Univ. of South Florida, Tampa, Fl.#TAB#","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040767961","display_name":"David D. Michie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Michie","raw_affiliation_strings":["University of South Florida, Tampa, FL","Univ. of South Florida, Tampa, Fl.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Univ. of South Florida, Tampa, Fl.#TAB#","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025536559","display_name":"Udho Thadani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Udho Thadani","raw_affiliation_strings":["University of South Florida, Tampa, FL","Univ. of South Florida, Tampa, Fl.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Univ. of South Florida, Tampa, Fl.#TAB#","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048920541","display_name":"Wolfgang M. Baiker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang M. Baiker","raw_affiliation_strings":["University of South Florida, Tampa, FL","Univ. of South Florida, Tampa, Fl.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Univ. of South Florida, Tampa, Fl.#TAB#","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046816000","display_name":"The Zatebradine Investigators","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zatebradine Investigators I","raw_affiliation_strings":["University of South Florida, Tampa, FL","Univ. of South Florida, Tampa, Fl.#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Univ. of South Florida, Tampa, Fl.#TAB#","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":{"value":7166,"currency":"USD","value_usd":7166},"apc_paid":null,"fwci":1.216,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.80660892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"2","first_page":"127A","last_page":"127A"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zatebradine","display_name":"zatebradine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/angina","display_name":"angina pectoris","score":0.8560000061988831},{"id":"https://openalex.org/keywords/exercise-induced-angina","display_name":"exercise-induced angina","score":0.8510000109672546},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/st-segment-depression","display_name":"ST-segment depression","score":0.7599999904632568},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.5590000152587891},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.4580000042915344},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.6489999890327454},{"id":"https://openalex.org/keywords/negative-inotropic-effect","display_name":"negative inotropic effect","score":0.6629999876022339},{"id":"https://openalex.org/keywords/dose-ranging-study","display_name":"dose-ranging","score":0.5799999833106995},{"id":"https://openalex.org/keywords/symptom-limited-exercise-test","display_name":"symptom-limited exercise test","score":0.5659999847412109},{"id":"https://openalex.org/keywords/myocardial-oxygen-supply","display_name":"myocardial oxygen supply","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9322214722633362},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.763487696647644},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.6682344675064087},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6120112538337708},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5953459739685059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5311564207077026},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5101523995399475},{"id":"https://openalex.org/C158328960","wikidata":"https://www.wikidata.org/wiki/Q1088369","display_name":"Chronotropic","level":4,"score":0.44491660594940186},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3912571668624878},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.15569904446601868},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0735-1097(95)91980-c","doi":"https://doi.org/10.1016/0735-1097(95)91980-c","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0735-1097(95)91980-c","pdf_url":"https://www.sciencedirect.com/science/article/pii/073510979591980C/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/0735-1097(95)91980-c","doi":"https://doi.org/10.1016/0735-1097(95)91980-c","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0735-1097(95)91980-c","pdf_url":"https://www.sciencedirect.com/science/article/pii/073510979591980C/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2051919738.pdf","grobid_xml":"https://content.openalex.org/works/W2051919738.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978745582","https://openalex.org/W4300858805","https://openalex.org/W2002632985","https://openalex.org/W2083599356","https://openalex.org/W63901051","https://openalex.org/W2022701847","https://openalex.org/W2090658115","https://openalex.org/W1975938050","https://openalex.org/W2072748812","https://openalex.org/W2013993455"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}