{"id":"https://openalex.org/W2051905313","doi":"https://doi.org/10.1016/0022-4731(90)90167-q","title":"Inhibitory effect of a new androstenedione derivative, 14\u03b1-hydroxy-4-androstene-3,6,17-trione (14\u03b1-OHAT) on aromatase activity of human uterine tumors","display_name":"Inhibitory effect of a new androstenedione derivative, 14\u03b1-hydroxy-4-androstene-3,6,17-trione (14\u03b1-OHAT) on aromatase activity of human uterine tumors","publication_year":1990,"publication_date":"1990-08-01","ids":{"openalex":"https://openalex.org/W2051905313","doi":"https://doi.org/10.1016/0022-4731(90)90167-q","mag":"2051905313","pmid":"https://pubmed.ncbi.nlm.nih.gov/2214767"},"language":"en","primary_location":{"id":"doi:10.1016/0022-4731(90)90167-q","doi":"https://doi.org/10.1016/0022-4731(90)90167-q","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-4731(90)90167-q","pdf_url":null,"source":{"id":"https://openalex.org/S104308233","display_name":"Journal of Steroid Biochemistry","issn_l":"0022-4731","issn":["0022-4731","1878-2353"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Steroid Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102030729","display_name":"Takara Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yamamoto Takara","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fukuoka Masaaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fukuoka Masaaki","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111757782","display_name":"Yasuko Fujimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fujimoto Yasuko","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112642406","display_name":"Kitawaki Jo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kitawaki Jo","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063686614","display_name":"Masamichi Nakakoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141468","display_name":"Megmilk Snow Brand (Japan)","ror":"https://ror.org/03y46gc61","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210141468"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nakakoshi Masamichi","raw_affiliation_strings":["Research Institute of Life Science, Snow Brand Milk Products Co. Ltd, Tochigi 329-05, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Life Science, Snow Brand Milk Products Co. Ltd, Tochigi 329-05, Japan","institution_ids":["https://openalex.org/I4210141468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111779675","display_name":"Makoto Yoshihama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141468","display_name":"Megmilk Snow Brand (Japan)","ror":"https://ror.org/03y46gc61","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210141468"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihama Makoto","raw_affiliation_strings":["Research Institute of Life Science, Snow Brand Milk Products Co. Ltd, Tochigi 329-05, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Life Science, Snow Brand Milk Products Co. Ltd, Tochigi 329-05, Japan","institution_ids":["https://openalex.org/I4210141468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079430587","display_name":"Hiroji Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Okada Hiroji","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto 602, Japan","institution_ids":["https://openalex.org/I40677808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102030729"],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":null,"apc_paid":null,"fwci":0.1566,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.44638404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"36","issue":"6","first_page":"517","last_page":"521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aromatase-inhibition","display_name":"aromatase inhibition","score":0.8069999814033508},{"id":"https://openalex.org/keywords/uterine-tumors","display_name":"uterine tumors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/uterine-fibroids","display_name":"uterine fibroids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adenomyosis","display_name":"adenomyosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/estrogen-biosynthesis","display_name":"estrogen synthesis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/menopausal-women","display_name":"menopausal women","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.9422972202301025},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7263566255569458},{"id":"https://openalex.org/C2778504769","wikidata":"https://www.wikidata.org/wiki/Q3040305","display_name":"Aromatase inhibitor","level":5,"score":0.629652738571167},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5990729331970215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5896134376525879},{"id":"https://openalex.org/C3017725331","wikidata":"https://www.wikidata.org/wiki/Q556281","display_name":"Uterine leiomyoma","level":3,"score":0.5711399912834167},{"id":"https://openalex.org/C2779166600","wikidata":"https://www.wikidata.org/wiki/Q2012569","display_name":"Adenomyosis","level":3,"score":0.5429558157920837},{"id":"https://openalex.org/C2776683971","wikidata":"https://www.wikidata.org/wiki/Q411064","display_name":"Androstenedione","level":4,"score":0.5385395884513855},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5075725317001343},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.4696556627750397},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.4004395604133606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35241764783859253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29129207134246826},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.26845234632492065},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24657747149467468},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.22998535633087158},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.16738805174827576}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000737","descriptor_name":"Androstenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001141","descriptor_name":"Aromatase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-4731(90)90167-q","doi":"https://doi.org/10.1016/0022-4731(90)90167-q","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-4731(90)90167-q","pdf_url":null,"source":{"id":"https://openalex.org/S104308233","display_name":"Journal of Steroid Biochemistry","issn_l":"0022-4731","issn":["0022-4731","1878-2353"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Steroid Biochemistry","raw_type":"journal-article"},{"id":"pmid:2214767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2214767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of steroid biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1527902556","https://openalex.org/W1751477744","https://openalex.org/W1938064253","https://openalex.org/W1968209553","https://openalex.org/W1983190335","https://openalex.org/W2009307286","https://openalex.org/W2013683886","https://openalex.org/W2035163308","https://openalex.org/W2035890891","https://openalex.org/W2059441670","https://openalex.org/W2066084415","https://openalex.org/W2070277181","https://openalex.org/W2093086778","https://openalex.org/W2169739545","https://openalex.org/W2284025352","https://openalex.org/W6640587550"],"related_works":["https://openalex.org/W2003148204","https://openalex.org/W602415349","https://openalex.org/W1964010683","https://openalex.org/W2029458486","https://openalex.org/W2037255793","https://openalex.org/W2121688364","https://openalex.org/W1994587492","https://openalex.org/W2065107011","https://openalex.org/W2050502170","https://openalex.org/W2888323048"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}