{"id":"https://openalex.org/W2051901416","doi":"https://doi.org/10.3390/md11093224","title":"Epigonal Conditioned Media from Bonnethead Shark, Sphyrna tiburo, Induces Apoptosis in a T-Cell Leukemia Cell Line, Jurkat E6-1","display_name":"Epigonal Conditioned Media from Bonnethead Shark, Sphyrna tiburo, Induces Apoptosis in a T-Cell Leukemia Cell Line, Jurkat E6-1","publication_year":2013,"publication_date":"2013-08-26","ids":{"openalex":"https://openalex.org/W2051901416","doi":"https://doi.org/10.3390/md11093224","mag":"2051901416","pmid":"https://pubmed.ncbi.nlm.nih.gov/24065163","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3806469"},"language":"en","primary_location":{"id":"doi:10.3390/md11093224","doi":"https://doi.org/10.3390/md11093224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md11093224","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/md11093224","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001580687","display_name":"Catherine J. Walsh","orcid":"https://orcid.org/0000-0002-8279-5542","observed_orcids":["https://orcid.org/0000-0002-8279-5542"]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Catherine Walsh","raw_affiliation_strings":["Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112497092","display_name":"Carl A. Luer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl Luer","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110162537","display_name":"Jennifer E. Yordy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Yordy","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]},{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078878075","display_name":"Theresa M. Cantu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Cantu","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]},{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014945540","display_name":"Jodi Miedema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jodi Miedema","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]},{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056885875","display_name":"Stephanie R. Leggett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Leggett","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]},{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035567142","display_name":"Brittany A. Leigh","orcid":"https://orcid.org/0000-0001-5668-9925","observed_orcids":["https://orcid.org/0000-0001-5668-9925"]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany Leigh","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]},{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Philip Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Adams","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]},{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114112530","display_name":"Marissa R Ciesla","orcid":"https://orcid.org/0000-0002-8424-324X","observed_orcids":["https://orcid.org/0000-0002-8424-324X"]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Ciesla","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]},{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110099297","display_name":"Courtney Bennett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800735176","display_name":"Mote Marine Laboratory","ror":"https://ror.org/02rkzhe22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800735176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney Bennett","raw_affiliation_strings":["Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Biomedical Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]},{"raw_affiliation_string":"Marine Immunology Program, Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA","institution_ids":["https://openalex.org/I2800735176"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110107289","display_name":"Ashby B. Bodine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashby Bodine","raw_affiliation_strings":["Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001580687"],"corresponding_institution_ids":["https://openalex.org/I2800735176"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.2199,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.503085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"9","first_page":"3224","last_page":"3257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4325999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4325999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11387","display_name":"Ichthyology and Marine Biology","score":0.266400009393692,"subfield":{"id":"https://openalex.org/subfields/2309","display_name":"Nature and Landscape Conservation"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bonnethead-shark","display_name":"bonnethead shark","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sphyrna-tiburo","display_name":"Sphyrna tiburo","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/jurkat-e6-1-cells","display_name":"Jurkat E6.1 cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/t-cell-leukemia","display_name":"T-cell leukemia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chondrichthyes","display_name":"Chondrichthyes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.9599303007125854},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7286093235015869},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6658250689506531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6429862976074219},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6054229736328125},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.553460955619812},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5511795282363892},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45691993832588196},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4286416172981262},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4158182740211487},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2956283390522003},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2498542070388794},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21124881505966187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16357365250587463},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1617394983768463}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012754","descriptor_name":"Sharks","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017304","descriptor_name":"Annexin A5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/md11093224","doi":"https://doi.org/10.3390/md11093224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md11093224","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2794793","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3806469","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3806469","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3806469","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mar Drugs","raw_type":"Text"},{"id":"pmid:24065163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24065163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.698.1812","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.698.1812","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1660-3397/11/9/3224/pdf/","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f284b3bd6ffb469486ff6065f00aa480","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f284b3bd6ffb469486ff6065f00aa480","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 11, Iss 9, Pp 3224-3257 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/md11093224","doi":"https://doi.org/10.3390/md11093224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md11093224","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5701520600","display_name":"Anisotropy as a Probe of Chirality","funder_award_id":"F32GM077017","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W32378874","https://openalex.org/W125106425","https://openalex.org/W206121492","https://openalex.org/W1536053153","https://openalex.org/W1577577364","https://openalex.org/W1590471414","https://openalex.org/W1604195255","https://openalex.org/W1759824788","https://openalex.org/W1775749144","https://openalex.org/W1935002882","https://openalex.org/W1942214720","https://openalex.org/W1971673386","https://openalex.org/W1974070035","https://openalex.org/W1977270003","https://openalex.org/W1977290823","https://openalex.org/W1979174576","https://openalex.org/W1981006523","https://openalex.org/W1986362740","https://openalex.org/W1993118551","https://openalex.org/W1993327789","https://openalex.org/W1995638825","https://openalex.org/W1995826417","https://openalex.org/W1999653222","https://openalex.org/W2008757142","https://openalex.org/W2012985988","https://openalex.org/W2019038132","https://openalex.org/W2022803736","https://openalex.org/W2023528999","https://openalex.org/W2025201985","https://openalex.org/W2028512857","https://openalex.org/W2030720872","https://openalex.org/W2039344765","https://openalex.org/W2042409437","https://openalex.org/W2045801606","https://openalex.org/W2049312704","https://openalex.org/W2064868405","https://openalex.org/W2068049794","https://openalex.org/W2075711428","https://openalex.org/W2077793109","https://openalex.org/W2078374613","https://openalex.org/W2079235964","https://openalex.org/W2088291142","https://openalex.org/W2089476060","https://openalex.org/W2092508425","https://openalex.org/W2093215851","https://openalex.org/W2094570524","https://openalex.org/W2100004532","https://openalex.org/W2100581111","https://openalex.org/W2100763429","https://openalex.org/W2102274308","https://openalex.org/W2103349496","https://openalex.org/W2105186639","https://openalex.org/W2107377459","https://openalex.org/W2107422848","https://openalex.org/W2111494467","https://openalex.org/W2112173903","https://openalex.org/W2113839929","https://openalex.org/W2114918609","https://openalex.org/W2121560754","https://openalex.org/W2127072511","https://openalex.org/W2130988210","https://openalex.org/W2132411546","https://openalex.org/W2135924782","https://openalex.org/W2149809888","https://openalex.org/W2155517651","https://openalex.org/W2159854824","https://openalex.org/W2161735235","https://openalex.org/W2161959295","https://openalex.org/W2166975108","https://openalex.org/W2168008823","https://openalex.org/W2499030852","https://openalex.org/W2501114744","https://openalex.org/W4231261634","https://openalex.org/W6608462696","https://openalex.org/W6676013346"],"related_works":["https://openalex.org/W7097616717","https://openalex.org/W2185881761","https://openalex.org/W2561961583","https://openalex.org/W2520389706","https://openalex.org/W2086184646","https://openalex.org/W3084043559","https://openalex.org/W1507975677","https://openalex.org/W2381989036","https://openalex.org/W3009914931","https://openalex.org/W2807686019"],"abstract_inverted_index":{"Representatives":[0],"of":[1,15,20,26,51,68,74,91,112,138,152,156,161,169,179],"Subclass":[2],"Elasmobranchii":[3],"are":[4],"cartilaginous":[5],"fish":[6],"whose":[7],"members":[8],"include":[9],"sharks,":[10],"skates,":[11],"and":[12,140],"rays.":[13],"Because":[14],"their":[16],"unique":[17],"phylogenetic":[18],"position":[19],"being":[21],"the":[22,31,39,47,55,71,149,167],"most":[23],"primitive":[24],"group":[25],"vertebrates":[27],"to":[28,82,132],"possess":[29,44],"all":[30],"components":[32,163],"necessary":[33],"for":[34,57,177],"an":[35,170],"adaptive":[36],"immune":[37,40],"system,":[38],"regulatory":[41],"compounds":[42,53],"they":[43],"may":[45,164],"represent":[46],"earliest":[48],"evolutionary":[49],"forms":[50],"novel":[52],"with":[54,134,173],"potential":[56,174],"innovative":[58],"therapeutic":[59,175],"applications.":[60],"Conditioned":[61],"medium,":[62],"generated":[63],"from":[64,70],"short":[65],"term":[66],"culture":[67],"cells":[69],"epigonal":[72,102],"organ":[73],"bonnethead":[75],"sharks":[76],"(Sphyrna":[77],"tiburo),":[78],"has":[79],"been":[80],"shown":[81],"have":[83],"potent":[84],"reproducible":[85],"cytotoxic":[86,108],"activity":[87,109],"against":[88],"a":[89,123],"variety":[90],"human":[92,180],"tumor":[93,125],"cell":[94,126],"lines":[95],"in":[96,114,122,130,166],"vitro.":[97],"Existing":[98],"data":[99],"suggest":[100],"that":[101,145],"conditioned":[103],"medium":[104],"(ECM)":[105],"exerts":[106],"this":[107],"through":[110,154],"induction":[111,121],"apoptosis":[113,120,153],"target":[115],"cells.":[116],"This":[117],"manuscript":[118],"describes":[119],"representative":[124],"line,":[127],"Jurkat":[128],"E6-1,":[129],"response":[131],"treatment":[133,178],"ECM":[135,146,162],"at":[136],"concentrations":[137],"1":[139],"2":[141],"mg/mL.":[142],"Data":[143],"indicate":[144],"exposure":[147],"initiates":[148],"mitochondrial":[150],"pathway":[151],"activation":[155],"caspase":[157],"enzymes.":[158],"Future":[159],"purification":[160],"result":[165],"isolation":[168],"immune-regulatory":[171],"compound":[172],"benefit":[176],"cancer.":[181]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
