{"id":"https://openalex.org/W2051877942","doi":"https://doi.org/10.1073/pnas.87.19.7678","title":"Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.","display_name":"Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2051877942","doi":"https://doi.org/10.1073/pnas.87.19.7678","mag":"2051877942","pmid":"https://pubmed.ncbi.nlm.nih.gov/2217201","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/54811"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.87.19.7678","doi":"https://doi.org/10.1073/pnas.87.19.7678","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.87.19.7678","pdf_url":"https://www.pnas.org/content/pnas/87/19/7678.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/87/19/7678.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056217370","display_name":"Danny R. Welch","orcid":"https://orcid.org/0000-0002-1951-4947","observed_orcids":["https://orcid.org/0000-0002-1951-4947"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Welch","raw_affiliation_strings":["Division of Chemotherapy, Glaxo Research Laboratories, Research Triangle Park, NC 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemotherapy, Glaxo Research Laboratories, Research Triangle Park, NC 27709","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062447219","display_name":"\u00c0ngels Fabra","orcid":"https://orcid.org/0000-0003-3288-523X","observed_orcids":["https://orcid.org/0000-0003-3288-523X"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Fabra","raw_affiliation_strings":["Division of Chemotherapy, Glaxo Research Laboratories, Research Triangle Park, NC 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemotherapy, Glaxo Research Laboratories, Research Triangle Park, NC 27709","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021593247","display_name":"Motowo Nakajima","orcid":"https://orcid.org/0000-0001-7687-6365","observed_orcids":["https://orcid.org/0000-0001-7687-6365"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Nakajima","raw_affiliation_strings":["Division of Chemotherapy, Glaxo Research Laboratories, Research Triangle Park, NC 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemotherapy, Glaxo Research Laboratories, Research Triangle Park, NC 27709","institution_ids":["https://openalex.org/I4210114143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210114143"],"apc_list":null,"apc_paid":null,"fwci":5.0234,"has_fulltext":true,"cited_by_count":389,"citation_normalized_percentile":{"value":0.96444149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"87","issue":"19","first_page":"7678","last_page":"7682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mammary-adenocarcinoma","display_name":"mammary adenocarcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7480000257492065},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mtln3-cells","display_name":"MTLn3 cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/basement-membrane-penetration","display_name":"basement membrane penetration","score":0.6940000057220459},{"id":"https://openalex.org/keywords/type-iv-collagenase","display_name":"type IV collagenase","score":0.7789999842643738},{"id":"https://openalex.org/keywords/heparanase","display_name":"heparanase","score":0.8830000162124634},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/anti-tgf-beta-antibody","display_name":"anti-TGF-beta antibody","score":0.781000018119812},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5447931289672852},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.5341013669967651},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.5214040279388428},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5150782465934753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4726547300815582},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46550992131233215},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.4574022889137268},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4556368887424469},{"id":"https://openalex.org/C48900799","wikidata":"https://www.wikidata.org/wiki/Q1424376","display_name":"Doubling time","level":3,"score":0.4548642039299011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39493682980537415},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39486435055732727},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38203564286231995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3669992685317993},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33368366956710815},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.277937650680542},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18700015544891357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18095386028289795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12617230415344238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.87.19.7678","doi":"https://doi.org/10.1073/pnas.87.19.7678","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.87.19.7678","pdf_url":"https://www.pnas.org/content/pnas/87/19/7678.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:54811","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/54811","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2217201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2217201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"mag:2189499560","doi":null,"is_oa":false,"landing_page_url":"http://www.pnas.org/content/87/19/7678.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2764504779","doi":null,"is_oa":false,"landing_page_url":"https://ci.nii.ac.jp/naid/80005470511","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci USA","raw_type":null}],"best_oa_location":{"id":"doi:10.1073/pnas.87.19.7678","doi":"https://doi.org/10.1073/pnas.87.19.7678","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.87.19.7678","pdf_url":"https://www.pnas.org/content/pnas/87/19/7678.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3275790622","display_name":"TUMOR BASEMENT MEMBRANE DEGRADING ENZYMES","funder_award_id":"R01CA041524","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2051877942.pdf","grobid_xml":"https://content.openalex.org/works/W2051877942.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W367573814","https://openalex.org/W1505978562","https://openalex.org/W1507007824","https://openalex.org/W1517977083","https://openalex.org/W1596449567","https://openalex.org/W1600831053","https://openalex.org/W1610858456","https://openalex.org/W1808371613","https://openalex.org/W1819831344","https://openalex.org/W1921315347","https://openalex.org/W1921965923","https://openalex.org/W1975812938","https://openalex.org/W1976735940","https://openalex.org/W1990199988","https://openalex.org/W1992172901","https://openalex.org/W1993771380","https://openalex.org/W1995746818","https://openalex.org/W1999903411","https://openalex.org/W2010433459","https://openalex.org/W2018289835","https://openalex.org/W2035819392","https://openalex.org/W2042265187","https://openalex.org/W2049759076","https://openalex.org/W2051231839","https://openalex.org/W2057409901","https://openalex.org/W2063227628","https://openalex.org/W2068769994","https://openalex.org/W2069752587","https://openalex.org/W2075404842","https://openalex.org/W2087863947","https://openalex.org/W2091857312","https://openalex.org/W2100837269","https://openalex.org/W2102344606","https://openalex.org/W2106480106","https://openalex.org/W2108104357","https://openalex.org/W2124411815","https://openalex.org/W2133651261","https://openalex.org/W2137754721","https://openalex.org/W2138098601","https://openalex.org/W2158565740","https://openalex.org/W2399709338","https://openalex.org/W2403703460","https://openalex.org/W2437457294","https://openalex.org/W6611816604","https://openalex.org/W6699767710","https://openalex.org/W6725056988","https://openalex.org/W6730382510"],"related_works":["https://openalex.org/W2189499560","https://openalex.org/W2764504779","https://openalex.org/W2049861779","https://openalex.org/W2145388051","https://openalex.org/W3146112098","https://openalex.org/W1992709825","https://openalex.org/W2437989554","https://openalex.org/W2369406022","https://openalex.org/W2186017317","https://openalex.org/W2068305315"],"abstract_inverted_index":{"The":[0,66],"experimental":[1],"metastatic":[2,103,226],"potential":[3,104,148,227],"of":[4,51,72,83,112,142,175,189,228],"13762NF":[5],"mammary":[6,229],"adenocarcinoma":[7],"clone":[8],"MTLn3":[9,124,176],"was":[10,55,68,90,193,216],"tested":[11,117],"after":[12,33],"pretreatment":[13],"in":[14,35,49,118,152,160,169,186,195],"serum-free":[15,196],"medium":[16],"containing":[17],"transforming":[18],"growth":[19,182,192],"factor":[20],"(TGF)":[21],"beta":[22],"1":[23,85,144,173,223],"at":[24,60,80],"0-5000":[25],"pg/ml.":[26],"Lung":[27],"colonies":[28],"were":[29],"measured":[30],"2":[31],"weeks":[32],"inoculation":[34],"syngeneic":[36],"F344":[37],"rats,":[38],"and":[39,165,239],"a":[40,155,166],"bell-shaped":[41],"dose-response":[42],"curve":[43],"with":[44],"2-":[45,130,156],"to":[46,106,114,131,154,157,200,208,236],"3-fold":[47],"increase":[48,159,168],"number":[50],"surface":[52],"lung":[53],"metastases":[54],"seen.":[56],"Maximal":[57],"enhancement":[58],"occurred":[59],"the":[61,77,119,187],"50":[62],"pg/ml":[63],"dose":[64],"level.":[65],"effect":[67,98],"specific":[69],"because":[70],"addition":[71],"neutralizing":[73,93],"anti-TGF-beta":[74,94],"antibody":[75,89,95],"blocked":[76],"stimulatory":[78],"activity":[79],"all":[81],"levels":[82],"TGF-beta":[84,143,172,222],"pretreatment,":[86],"but":[87],"when":[88],"given":[91],"alone,":[92],"had":[96],"no":[97],"on":[99],"untreated":[100,136],"cells.":[101],"Increased":[102,146],"appears":[105],"be":[107],"from":[108],"an":[109],"increased":[110],"propensity":[111],"cells":[113,125,177,231],"extravasate":[115],"as":[116],"membrane":[120,212],"invasion":[121],"culture":[122],"system.":[123],"penetrated":[126],"reconstituted":[127,210],"basement-membrane":[128,241],"barriers":[129],"3.5-fold":[132],"more":[133],"than":[134],"did":[135,178],"control":[137],"cells,":[138],"depending":[139],"upon":[140],"length":[141],"exposure.":[145],"invasive":[147],"is":[149],"apparently":[150],"due,":[151],"part,":[153],"6-fold":[158],"type":[161],"IV":[162],"collagenolytic":[163],"(gelatinolytic)":[164],"2.4-fold":[167],"heparanase":[170],"activity.":[171],"treatment":[174],"not":[179],"alter":[180],"their":[181,234],"rate":[183],"or":[184,207,213],"morphology":[185],"presence":[188],"serum;":[190],"however,":[191],"inhibited":[194],"medium.":[197],"Likewise,":[198],"adhesion":[199],"human":[201],"umbilical":[202],"vein":[203],"endothelial":[204],"cell":[205],"monolayers":[206],"immobilized":[209],"basement":[211],"fibronectin":[214],"matrices":[215],"unchanged.":[217],"These":[218],"results":[219],"suggest":[220],"that":[221],"may":[224],"modulate":[225],"tumor":[230],"by":[232],"controlling":[233],"ability":[235],"break":[237],"down":[238],"penetrate":[240],"barriers.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}