{"id":"https://openalex.org/W2051876644","doi":"https://doi.org/10.1093/jnci/84.21.1638","title":"Mutations of p53 Gene in Hepatocellular Carcinoma: Roles of Hepatitis B Virus and Aflatoxin Contamination in the Diet","display_name":"Mutations of p53 Gene in Hepatocellular Carcinoma: Roles of Hepatitis B Virus and Aflatoxin Contamination in the Diet","publication_year":1992,"publication_date":"1992-11-04","ids":{"openalex":"https://openalex.org/W2051876644","doi":"https://doi.org/10.1093/jnci/84.21.1638","mag":"2051876644","pmid":"https://pubmed.ncbi.nlm.nih.gov/1279184"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/84.21.1638","doi":"https://doi.org/10.1093/jnci/84.21.1638","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/84.21.1638","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113654260","display_name":"Chu Chieh Hsia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. C. Hsia","raw_affiliation_strings":["Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019378601","display_name":"David Erwin Kleiner","orcid":"https://orcid.org/0000-0003-3442-4453","observed_orcids":["https://orcid.org/0000-0003-3442-4453"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. E. Kleiner","raw_affiliation_strings":["Laboratory of Pathology, Division of Cancer Biology, Diagnosis, and Centers. National Cancer Institute, National Institutes of Health Bethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Division of Cancer Biology, Diagnosis, and Centers. National Cancer Institute, National Institutes of Health Bethesda, Md","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065422948","display_name":"Constantine A. Axiotis","orcid":"https://orcid.org/0000-0001-6377-8854","observed_orcids":["https://orcid.org/0000-0001-6377-8854"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. A. Axiotis","raw_affiliation_strings":["Albany Medical College Albany, N.Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany Medical College Albany, N.Y","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022731052","display_name":"Adrian M. Di Bisceglie","orcid":"https://orcid.org/0000-0002-6075-9305","observed_orcids":["https://orcid.org/0000-0002-6075-9305"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. D. Bisceglie","raw_affiliation_strings":["Hepatitis Studies Section, Degestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthBethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatitis Studies Section, Degestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthBethesda, Md","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113540009","display_name":"Abraham M. Y. Nomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. M. Y. Nomura","raw_affiliation_strings":["Kuakini Medical Center Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center Honolulu, Hawaii","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109119862","display_name":"Grant N. Stemmermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312008915","display_name":"Kuakini Medical Center","ror":"https://ror.org/002yfn631","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1312008915"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. N. Stemmermann","raw_affiliation_strings":["Kuakini Medical Center Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuakini Medical Center Honolulu, Hawaii","institution_ids":["https://openalex.org/I1312008915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066528087","display_name":"Edward Tabor","orcid":"https://orcid.org/0000-0001-8027-675X","observed_orcids":["https://orcid.org/0000-0001-8027-675X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E. Tabor","raw_affiliation_strings":["Biological Carcinogenesis Program, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health Bethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Carcinogenesis Program, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health Bethesda, Md","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066528087"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":3.3173,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.93633581,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"84","issue":"21","first_page":"1638","last_page":"1641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.34470000863075256,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.34470000863075256,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.26100000739097595,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.16740000247955322,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.8379999995231628},{"id":"https://openalex.org/keywords/aflatoxins","display_name":"aflatoxins","score":0.9200000166893005},{"id":"https://openalex.org/keywords/dietary-aflatoxin-exposure","display_name":"dietary aflatoxin exposure","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7789999842643738},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.8230000138282776},{"id":"https://openalex.org/keywords/liver-cancer-etiology","display_name":"liver cancer etiology","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hawaii","display_name":"Hawaii","score":0.43299999833106995},{"id":"https://openalex.org/keywords/united-states","display_name":"United States","score":0.42399999499320984},{"id":"https://openalex.org/keywords/p53-expression","display_name":"p53 expression","score":0.5360000133514404},{"id":"https://openalex.org/keywords/carcinogenesis-mechanisms","display_name":"carcinogenesis mechanisms","score":0.4749999940395355},{"id":"https://openalex.org/keywords/regional-variation","display_name":"regional variation","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8568029403686523},{"id":"https://openalex.org/C40758303","wikidata":"https://www.wikidata.org/wiki/Q212936","display_name":"Aflatoxin","level":2,"score":0.824805736541748},{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.8070062398910522},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6921833157539368},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.5844472050666809},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4823157787322998},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4623246490955353},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4380272626876831},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.43045923113822937},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.43030282855033875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43014734983444214},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.42786356806755066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4108763337135315},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4000091552734375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3777986764907837},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35067111253738403},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3207944929599762},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3140653371810913},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08013704419136047},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000348","descriptor_name":"Aflatoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003043","descriptor_name":"Cocarcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005506","descriptor_name":"Food Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006254","descriptor_name":"Hawaii","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jnci/84.21.1638","doi":"https://doi.org/10.1093/jnci/84.21.1638","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/84.21.1638","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:1279184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1279184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6600000262260437}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1651029566","https://openalex.org/W2084201653","https://openalex.org/W2118502941","https://openalex.org/W2012034172","https://openalex.org/W7098221260","https://openalex.org/W7096273383","https://openalex.org/W2061777320","https://openalex.org/W2340162342","https://openalex.org/W2143104787","https://openalex.org/W2059465863"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mutations":[1,283],"of":[2,13,29,35,42,54,80,88,97,126,129,185,212,217,226,232,240,250,260,264,284,304,323,352],"the":[3,38,51,55,86,100,120,165,177,182,199,210,237,241,258,265,277,285,302,349],"p53":[4,30,43,89,107,205,252,289,328],"tumor":[5,286],"suppressor":[6,287],"gene":[7,90,288,329],"have":[8,47],"been":[9],"reported":[10],"in":[11,37,74,99,123,164,176,198,209,254,262,272,290,344],"50%":[12],"patients":[14,157,172,219,228,273,297],"with":[15,32,316],"hepatocellular":[16,291],"carcinoma":[17],"(HCC)":[18],"from":[19,134,139,155,158,170,173,181,214,220,223,236,274,298],"China":[20,221,275],"and":[21,44,102,109,128,148,169,189,222,229,257,276,327],"South":[22],"Africa.":[23],"These":[24],"reports":[25],"suggested":[26,331],"an":[27],"association":[28,247],"mutations":[31,312],"high":[33,93],"levels":[34,96,163,197],"aflatoxin":[36,98,162,196,305],"diet.":[39],"Most":[40],"studies":[41],"HCC,":[45],"however,":[46],"not":[48,294],"fully":[49],"evaluated":[50,116],"possible":[52,321],"role":[53],"hepatitis":[56,110],"B":[57,111],"virus":[58],"(HBV).":[59],"Aflatoxin":[60],"is":[61,69,306],"a":[62,336],"substance":[63],"produced":[64],"by":[65,117,332,338],"food":[66],"mold":[67],"that":[68],"known":[70],"to":[71,84,92,103,296,348],"cause":[72],"HCC":[73,127,255],"experimental":[75],"animals.":[76],"PURPOSE:":[77],"The":[78,320],"purpose":[79],"this":[81],"study":[82],"was":[83,207,270],"evaluate":[85],"relationship":[87],"mutation":[91],"or":[94],"low":[95],"diet":[101,166,200],"HBV":[104,317,325,340],"infection.":[105,318],"METHODS:":[106],"protein":[108,206,253],"surface":[112],"antigen":[113],"(HBsAg)":[114],"were":[115,144,153],"immunohistochemistry":[118],"using":[119],"avidin-biotin-peroxidase":[121],"system":[122],"paraffin-embedded":[124],"specimens":[125,138],"adjacent":[130,149,266],"nontumorous":[131,150,267],"liver":[132,151,268],"tissue":[133,269],"43":[135],"patients.":[136],"Tissue":[137],"three":[140,224],"normal":[141],"human":[142],"livers":[143],"also":[145],"evaluated.":[146],"HCCs":[147,213],"tissues":[152],"obtained":[154],"23":[156,218],"Qidong,":[159],"China,":[160],"where":[161,195,301],"are":[167,201,293],"high,":[168],"20":[171],"two":[174,238],"regions":[175,239,300],"United":[178,242,278],"States":[179,279],"(patients":[180],"National":[183],"Institutes":[184],"Health,":[186],"Bethesda,":[187],"Md.,":[188],"Kuakini":[190],"Medical":[191],"Center,":[192],"Honolulu,":[193],"Hawaii),":[194],"low.":[202],"RESULTS:":[203],"Mutant":[204],"detected":[208],"nuclei":[211],"14":[215],"(61%)":[216],"(30%)":[225],"10":[227,233],"six":[230],"(60%)":[231],"patients,":[234,310],"respectively,":[235],"States.":[243],"A":[244],"statistically":[245],"significant":[246],"between":[248],"detection":[249,259],"mutant":[251],"cells":[256],"HBsAg":[261],"hepatocytes":[263],"observed":[271],"considered":[280],"together.":[281],"CONCLUSION:":[282],"carcinomas":[292],"limited":[295],"geographic":[299],"ingestion":[303],"high.":[307],"In":[308],"many":[309],"these":[311,333],"may":[313],"be":[314],"associated":[315],"IMPLICATIONS:":[319],"interaction":[322],"chronic":[324],"infection":[326,341],"mutation,":[330],"data,":[334],"indicates":[335],"mechanism":[337],"which":[339],"beginning":[342],"early":[343],"life":[345],"could":[346],"contribute":[347],"subsequent":[350],"development":[351],"HCC.":[353]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
