{"id":"https://openalex.org/W2051874642","doi":"https://doi.org/10.1128/jvi.79.14.9315-9319.2005","title":"Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and Alpha/Beta Interferon Responsiveness","display_name":"Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and Alpha/Beta Interferon Responsiveness","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2051874642","doi":"https://doi.org/10.1128/jvi.79.14.9315-9319.2005","mag":"2051874642","pmid":"https://pubmed.ncbi.nlm.nih.gov/15994826","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1168759"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.79.14.9315-9319.2005","doi":"https://doi.org/10.1128/jvi.79.14.9315-9319.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.14.9315-9319.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1168759","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045213613","display_name":"Mindy S. Lo","orcid":"https://orcid.org/0000-0003-2328-3536","observed_orcids":["https://orcid.org/0000-0003-2328-3536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mindy S. Lo","raw_affiliation_strings":["Departments of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062865164","display_name":"Robert M. Brazas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Brazas","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036584012","display_name":"Michael J. Holtzman","orcid":"https://orcid.org/0000-0001-8750-3716","observed_orcids":["https://orcid.org/0000-0001-8750-3716"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael J. Holtzman","raw_affiliation_strings":["Cell Biology, Washington University School of Medicine, St. Louis, Missouri 63110","Departments of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Washington University School of Medicine, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Departments of Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036584012"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":6.2579,"has_fulltext":false,"cited_by_count":295,"citation_normalized_percentile":{"value":0.97325858,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"79","issue":"14","first_page":"9315","last_page":"9319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":1.0},{"id":"https://openalex.org/keywords/ns1-protein","display_name":"NS1 protein","score":0.6100000143051147},{"id":"https://openalex.org/keywords/ns-2","display_name":"NS2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/stat2","display_name":"STAT2","score":0.8149999976158142},{"id":"https://openalex.org/keywords/interferon-alpha-beta-signaling","display_name":"interferon-alpha/beta signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/interferon-antagonism","display_name":"interferon antagonism","score":0.8489999771118164},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.7289999723434448},{"id":"https://openalex.org/keywords/host-range","display_name":"host range","score":0.7860000133514404},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/antiviral-response","display_name":"antiviral response","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8684831857681274},{"id":"https://openalex.org/C2776239193","wikidata":"https://www.wikidata.org/wiki/Q18031750","display_name":"STAT2","level":5,"score":0.7590975761413574},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6722110509872437},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6358892917633057},{"id":"https://openalex.org/C2780813555","wikidata":"https://www.wikidata.org/wiki/Q911129","display_name":"Paramyxoviridae","level":4,"score":0.6306380033493042},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5744742751121521},{"id":"https://openalex.org/C2780355102","wikidata":"https://www.wikidata.org/wiki/Q1753162","display_name":"Mononegavirales","level":5,"score":0.5196318030357361},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4621622562408447},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.4540650248527527},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.43150794506073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27379241585731506},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2725915014743805},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.18775495886802673},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.12454161047935486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09456518292427063},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08679327368736267},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018113","descriptor_name":"Respiratory Syncytial Virus, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050795","descriptor_name":"STAT2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.79.14.9315-9319.2005","doi":"https://doi.org/10.1128/jvi.79.14.9315-9319.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.14.9315-9319.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:135468","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1168759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1168759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1168759","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:15994826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15994826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:135468","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1168759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1556530772","https://openalex.org/W1994246745","https://openalex.org/W2007583880","https://openalex.org/W2024166644","https://openalex.org/W2060523802","https://openalex.org/W2064727744","https://openalex.org/W2068160897","https://openalex.org/W2072482570","https://openalex.org/W2073684796","https://openalex.org/W2080706214","https://openalex.org/W2082466613","https://openalex.org/W2088087993","https://openalex.org/W2093718076","https://openalex.org/W2101653431","https://openalex.org/W2104707719","https://openalex.org/W2104898251","https://openalex.org/W2114724795","https://openalex.org/W2125333406","https://openalex.org/W2126620099","https://openalex.org/W2133889672","https://openalex.org/W2141266091","https://openalex.org/W2146648517","https://openalex.org/W2150152225","https://openalex.org/W2159370470","https://openalex.org/W4313331188"],"related_works":["https://openalex.org/W2023594156","https://openalex.org/W402940956","https://openalex.org/W6991978467","https://openalex.org/W4399652822","https://openalex.org/W2309622146","https://openalex.org/W2114884151","https://openalex.org/W1847166760","https://openalex.org/W1982927008","https://openalex.org/W2100223188","https://openalex.org/W2096886486"],"abstract_inverted_index":{"Respiratory":[0],"syncytial":[1],"virus":[2],"(RSV)":[3],"subverts":[4],"the":[5,11,56],"antiviral":[6],"interferon":[7],"(IFN)":[8],"response,":[9],"but":[10,76],"mechanism":[12,83],"for":[13],"this":[14,82],"evasion":[15],"was":[16],"unclear.":[17],"Here":[18],"we":[19],"show":[20],"that":[21],"RSV":[22,35,63,72],"preferentially":[23],"inhibits":[24],"IFN-alpha/beta":[25,59],"signaling":[26],"by":[27],"expression":[28,38],"of":[29,39,84],"viral":[30,90],"NS1":[31,41],"and":[32,42,55],"NS2.":[33],"Thus,":[34],"infection":[36,73],"or":[37,69],"recombinant":[40],"NS2":[43],"in":[44,52],"epithelial":[45],"host":[46,91],"cells":[47],"causes":[48],"a":[49],"marked":[50],"decrease":[51],"Stat2":[53,67,79],"levels":[54,68],"consequent":[57],"downstream":[58],"response.":[60],"Similarly,":[61],"NS1/NS2-deficient":[62],"no":[64],"longer":[65],"decreases":[66],"IFN":[70,85],"responsiveness.":[71],"decreased":[74],"human":[75],"not":[77],"mouse":[78],"levels,":[80],"so":[81],"antagonism":[86],"may":[87],"contribute":[88],"to":[89],"range,":[92],"as":[93,95],"well":[94],"immune":[96],"subversion.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}