{"id":"https://openalex.org/W2051847946","doi":"https://doi.org/10.1021/jm9903850","title":"Esterase-Sensitive Nitric Oxide Donors of the Diazeniumdiolate Family: In Vitro Antileukemic Activity","display_name":"Esterase-Sensitive Nitric Oxide Donors of the Diazeniumdiolate Family: In Vitro Antileukemic Activity","publication_year":1999,"publication_date":"1999-12-30","ids":{"openalex":"https://openalex.org/W2051847946","doi":"https://doi.org/10.1021/jm9903850","mag":"2051847946","pmid":"https://pubmed.ncbi.nlm.nih.gov/10649981"},"language":"en","primary_location":{"id":"doi:10.1021/jm9903850","doi":"https://doi.org/10.1021/jm9903850","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm9903850","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076715400","display_name":"Joseph E. Saavedra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Saavedra","raw_affiliation_strings":["Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I162714631","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103426984","display_name":"Paul J. Shami","orcid":"https://orcid.org/0000-0002-5696-6512","observed_orcids":["https://orcid.org/0000-0002-5696-6512"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Shami","raw_affiliation_strings":["Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I162714631","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111757600","display_name":"Lai Yi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lai Yi Wang","raw_affiliation_strings":["Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I162714631","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111868654","display_name":"Keith Maurice Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith M. Davies","raw_affiliation_strings":["Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I162714631","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057900531","display_name":"Melissa N. Booth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa N. Booth","raw_affiliation_strings":["Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I162714631","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090010191","display_name":"Michael L. Citro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Citro","raw_affiliation_strings":["Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I162714631","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069348197","display_name":"Larry K. Keefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Larry K. Keefer","raw_affiliation_strings":["Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intramural Research Support Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah 84148, Department of Chemistry, George Mason University, Fairfax, Virginia 22030, and Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I162714631","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069348197"],"corresponding_institution_ids":["https://openalex.org/I162714631","https://openalex.org/I4210140884"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.6787,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.95935826,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"2","first_page":"261","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.45089998841285706,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.45089998841285706,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.16850000619888306,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.054999999701976776,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazeniumdiolates","display_name":"diazeniumdiolates","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.9449999928474426},{"id":"https://openalex.org/keywords/esterase-hydrolysis","display_name":"esterase hydrolysis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/antileukemic-activity","display_name":"antileukemic activity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.40400001406669617},{"id":"https://openalex.org/keywords/prodrug-design","display_name":"prodrug design","score":0.5519999861717224},{"id":"https://openalex.org/keywords/ester-hydrolysis","display_name":"ester hydrolysis","score":0.5339999794960022},{"id":"https://openalex.org/keywords/antiproliferative-agents","display_name":"antiproliferative agents","score":0.75},{"id":"https://openalex.org/keywords/acetyl-protecting-group","display_name":"acetyl protecting group","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8916974067687988},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.8796569108963013},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.7206956744194031},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.6173033714294434},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5857804417610168},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5573441982269287},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5408722162246704},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.44124433398246765},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42507630586624146},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.328299343585968},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29429659247398376},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10419902205467224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004950","descriptor_name":"Esterases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007094","descriptor_name":"Imides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007094","descriptor_name":"Imides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007094","descriptor_name":"Imides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm9903850","doi":"https://doi.org/10.1021/jm9903850","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm9903850","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:10649981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10649981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3029148","display_name":null,"funder_award_id":"N01 CO 56000","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G588003333","display_name":"OPERATIONS &TECHNICAL SUPPORT","funder_award_id":"n01co056000-057","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W10965608","https://openalex.org/W93856634","https://openalex.org/W1600512751","https://openalex.org/W1979129905","https://openalex.org/W1998879311","https://openalex.org/W2023567086","https://openalex.org/W2061803752","https://openalex.org/W2083537936","https://openalex.org/W2148911589","https://openalex.org/W2314302518","https://openalex.org/W2951919375","https://openalex.org/W2952342392","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2061476154","https://openalex.org/W4234143607","https://openalex.org/W2107019802","https://openalex.org/W1989055821","https://openalex.org/W2015050865","https://openalex.org/W2068837546","https://openalex.org/W7095539350","https://openalex.org/W2020355467","https://openalex.org/W2049851888","https://openalex.org/W2004641607"],"abstract_inverted_index":{"We":[0],"have":[1],"designed":[2],"a":[3,139],"novel":[4,302],"prodrug":[5,134],"class":[6,135],"that":[7,196],"is":[8,136,191,198],"stable":[9],"in":[10,28,72,104,121,148,171,230,237,272,293],"neutral":[11],"aqueous":[12],"media":[13],"but":[14],"releases":[15],"bioactive":[16],"nitric":[17],"oxide":[18],"(NO)":[19],"on":[20,297],"metabolism":[21],"by":[22],"esterase.":[23],"Diazeniumdiolates":[24],"of":[25,80,107,125,132,141,179,264,276,284,300,329],"structure":[26],"R(2)N-N(O)=N-OR',":[27],"which":[29,238,243,314],"R'":[30,61,239],"=":[31,45,50,62,240],"Na,":[32],"were":[33,175,183,233],"reacted":[34],"with":[35,112,138,193],"BrCH(2)OAc":[36],"to":[37,52,66,201,205,252],"convert":[38],"the":[39,105,122,158,169,211,254,277,285,298,310,326],"spontaneously":[40],"NO-releasing":[41,255],"salts":[42],"1a":[43,68,115,162],"(R(2)N":[44,49],"diethylamino)":[46],"and":[47,56,69,83,88,143,155,163,181,185,203,217,245,268,274,282],"1b":[48,70,164],"pyrrolidino)":[51],"prodrugs":[53],"2a":[54,87,180,216,267],"(AcOM-DEA/NO)":[55],"2b":[57,89,182,218,269],"(AcOM-PYRRO/NO),":[58],"respectively,":[59],"where":[60],"CH(2)OAc.":[63],"In":[64],"contrast":[65],"anions":[67],"(half-lives":[71],"pH":[73],"7.4":[74],"phosphate":[75],"at":[76,261],"37":[77],"degrees":[78],"C":[79],"2":[81,144,197],"min":[82],"3":[84],"s,":[85],"respectively),":[86],"showed":[90],"only":[91],"minimal":[92],"decomposition":[93],"after":[94],"16":[95],"h":[96,260],"under":[97],"these":[98,301],"conditions.":[99],"Very":[100],"rapid":[101],"hydrolysis":[102],"occurred":[103],"presence":[106],"porcine":[108],"liver":[109],"esterase,":[110],"however,":[111],"free":[113,253],"anion":[114],"being":[116],"observed":[117,234],"as":[118,145,321],"an":[119],"intermediate":[120],"esterase-induced":[123],"generation":[124],"NO":[126,167,206],"from":[127,242,313],"2a.":[128],"The":[129,289],"potential":[130],"utility":[131],"this":[133],"illustrated":[137],"comparison":[140],"1":[142,202],"antiproliferative":[146,226],"agents":[147,323],"NO-sensitive":[149],"human":[150],"leukemia":[151],"cell":[152,173],"lines":[153],"HL-60":[154,172,278],"U937.":[156],"While":[157],"72-h":[159,212],"IC(50)'s":[160,227],"for":[161,214,235,324],"(which":[165],"generate":[166],"throughout":[168],"medium)":[170],"cultures":[174],">600":[176],"microM,":[177,187,266],"those":[178],"8.3":[184],"6.4":[186],"respectively.":[188],"This":[189],"result":[190],"consistent":[192],"our":[194],"hypothesis":[195],"selectively":[199],"hydrolyzed":[200],"thence":[204],"intracellularly.":[207],"For":[208],"U937":[209,231,286],"cells,":[210,279,287],"IC(50)":[213],"both":[215],"was":[219],"53":[220],"microM.":[221],"By":[222],"contrast,":[223],"relatively":[224],"high":[225],"(>100":[228],"microM":[229],"cells)":[232],"analogues":[236],"CH(2)CH(2)SC(O)Me,":[241],"acetyl":[244],"2-mercaptoethyl":[246],"groups":[247],"must":[248],"be":[249],"successively":[250],"cleaved":[251],"diazeniumdiolate":[256],"function.":[257],"Within":[258],"24":[259],"initial":[262],"concentrations":[263],"50":[265],"induced":[270],"apoptosis":[271],"50%":[273],"57%":[275],"respectively":[280],"(35%":[281],"40%":[283],"respectively).":[288],"data":[290],"reveal":[291],"significant":[292],"vitro":[294],"antileukemic":[295],"activity":[296],"part":[299],"compounds.":[303],"Moreover,":[304],"their":[305,319],"substantial":[306],"ease-of-handling":[307],"advantages":[308],"over":[309],"anionic":[311],"diazeniumdiolates":[312],"they":[315],"are":[316],"derived":[317],"suggest":[318],"use":[320],"convenient":[322],"probing":[325],"biological":[327],"roles":[328],"NO.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}