{"id":"https://openalex.org/W2051837586","doi":"https://doi.org/10.1161/01.cir.95.12.2643","title":"Early Versus Delayed Angiotensin-Converting Enzyme Inhibition Therapy in Acute Myocardial Infarction","display_name":"Early Versus Delayed Angiotensin-Converting Enzyme Inhibition Therapy in Acute Myocardial Infarction","publication_year":1997,"publication_date":"1997-06-17","ids":{"openalex":"https://openalex.org/W2051837586","doi":"https://doi.org/10.1161/01.cir.95.12.2643","mag":"2051837586","pmid":"https://pubmed.ncbi.nlm.nih.gov/9193433"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.95.12.2643","doi":"https://doi.org/10.1161/01.cir.95.12.2643","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.95.12.2643","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031560506","display_name":"Marc Alan Pfeffer","orcid":"https://orcid.org/0000-0003-3876-7568","observed_orcids":["https://orcid.org/0000-0003-3876-7568"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Marc A. Pfeffer","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031922587","display_name":"Sally Greaves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Sally C. Greaves","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104063614","display_name":"J. Malcolm O. Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"J. Malcolm O. Arnold","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037322697","display_name":"Robert J. Glynn","orcid":"https://orcid.org/0000-0002-0697-8996","observed_orcids":["https://orcid.org/0000-0002-0697-8996"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Robert J. Glynn","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105889466","display_name":"Frances LaMotte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Frances S. LaMotte","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020595766","display_name":"Richard Theodore Lee","orcid":"https://orcid.org/0000-0003-4687-1381","observed_orcids":["https://orcid.org/0000-0003-4687-1381","https://orcid.org/0000-0001-6156-1870"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Richard T. Lee","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113651343","display_name":"Francis J. Menapace","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Francis J. Menapace","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109125930","display_name":"Elliot Rapaport","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Elliot Rapaport","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091595592","display_name":"Paul M. Ridker","orcid":"https://orcid.org/0000-0003-1249-4522","observed_orcids":["https://orcid.org/0000-0003-1249-4522"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Paul M. Ridker","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111954509","display_name":"Jean Lucien Rouleau","orcid":"https://orcid.org/0000-0002-5353-3877","observed_orcids":["https://orcid.org/0000-0002-5353-3877"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Jean-Lucien Rouleau","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054830306","display_name":"Scott David Solomon","orcid":"https://orcid.org/0000-0003-3698-9597","observed_orcids":["https://orcid.org/0000-0003-3698-9597"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Scott D. Solomon","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006554574","display_name":"Charles H. Hennekens","orcid":"https://orcid.org/0000-0003-1214-1663","observed_orcids":["https://orcid.org/0000-0003-1214-1663"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800290161","display_name":"Montreal Heart Institute","ror":"https://ror.org/03vs03g62","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800290161","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Charles H. Hennekens","raw_affiliation_strings":["From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","Geisinger Medical Center (F.J.M.), Danville, Pa","University of California, San Francisco (E.R.)","Victoria Hospital (J.M.O.A.), London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Brigham and Women\u2019s Hospital (M.A.P., S.C.G., R.J.G., F.S.L., R.T.L., P.M.R., S.D.S., C.H.H.), Boston, Mass; Victoria Hospital (J.M.O.A.), London, Ontario, Canada; Geisinger Medical Center (F.J.M.), Danville, Pa; University of California, San Francisco (E.R.); and Montre\u0301al Heart Institute (J.L.R)., Montre\u0301al, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1293487830","https://openalex.org/I180670191","https://openalex.org/I2800290161","https://openalex.org/I4210108691"]},{"raw_affiliation_string":"Geisinger Medical Center (F.J.M.), Danville, Pa","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"University of California, San Francisco (E.R.)","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Victoria Hospital (J.M.O.A.), London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.5435,"has_fulltext":false,"cited_by_count":208,"citation_normalized_percentile":{"value":0.97657563,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"95","issue":"12","first_page":"2643","last_page":"2651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.17309999465942383,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.15199999511241913,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ramipril","display_name":"ramipril","score":0.7360000014305115},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.9369999766349792},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8650000095367432},{"id":"https://openalex.org/keywords/anterior-myocardial-infarction","display_name":"anterior myocardial infarction","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2779888176","wikidata":"https://www.wikidata.org/wiki/Q412666","display_name":"Ramipril","level":3,"score":0.979303240776062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9585133790969849},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7793288230895996},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.7205197811126709},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6504594087600708},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6256161332130432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5692753791809082},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.5326520800590515},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4874308407306671},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4207778573036194},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3872016668319702},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.28827983140945435}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017257","descriptor_name":"Ramipril","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017257","descriptor_name":"Ramipril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.95.12.2643","doi":"https://doi.org/10.1161/01.cir.95.12.2643","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.95.12.2643","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:9193433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9193433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W297892089","https://openalex.org/W1690120260","https://openalex.org/W1971971574","https://openalex.org/W1974947995","https://openalex.org/W1990224341","https://openalex.org/W1991977300","https://openalex.org/W1997277634","https://openalex.org/W2003435408","https://openalex.org/W2003563752","https://openalex.org/W2004114486","https://openalex.org/W2012781837","https://openalex.org/W2017361945","https://openalex.org/W2019956146","https://openalex.org/W2021671593","https://openalex.org/W2028273454","https://openalex.org/W2028301201","https://openalex.org/W2028455468","https://openalex.org/W2045001288","https://openalex.org/W2055519615","https://openalex.org/W2057667232","https://openalex.org/W2064279221","https://openalex.org/W2075653842","https://openalex.org/W2107644323","https://openalex.org/W2111151040","https://openalex.org/W2147750240","https://openalex.org/W2151504687","https://openalex.org/W2161178943","https://openalex.org/W2167773524","https://openalex.org/W2206375685","https://openalex.org/W2312388685","https://openalex.org/W2323549932","https://openalex.org/W2326132384","https://openalex.org/W2326354230","https://openalex.org/W2340149484","https://openalex.org/W2341695455","https://openalex.org/W2397187283","https://openalex.org/W2413765403","https://openalex.org/W2430960900","https://openalex.org/W2476265036","https://openalex.org/W2747176423","https://openalex.org/W2895806954","https://openalex.org/W4299483386"],"related_works":["https://openalex.org/W1972830962","https://openalex.org/W2092070457","https://openalex.org/W2063906967","https://openalex.org/W2015799309","https://openalex.org/W7009271774","https://openalex.org/W2142907276","https://openalex.org/W7215145991","https://openalex.org/W2038886837","https://openalex.org/W2028859656","https://openalex.org/W220526061"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"ACE":[2,61,257],"inhibitor":[3,62],"therapy":[4],"has":[5],"been":[6,29],"shown":[7],"to":[8,193],"reduce":[9],"mortality":[10],"in":[11,115,121,137,169,182],"patients":[12,40,183],"with":[13,41,184,202],"acute":[14],"myocardial":[15],"infarction":[16],"(MI),":[17],"the":[18,22,46,60,94,98,128,134,159,177,187,235,242,245],"optimal":[19],"dose":[20],"and":[21,48,74,157,199,217,225],"timing":[23],"of":[24,38,50,59,69,100,106,176,190,206,210,234,238,244,256],"its":[25],"initiation":[26,58],"have":[27,250],"not":[28,91,164,214],"determined.":[30],"METHODS":[31],"AND":[32],"RESULTS:":[33],"In":[34],"a":[35,102,166,203],"double-blind":[36],"trial":[37],"352":[39],"anterior":[42,185],"MI,":[43,186],"we":[44],"compared":[45],"safety":[47],"effectiveness":[49],"early":[51,188,236,253],"(day":[52,56],"1)":[53],"versus":[54],"delayed":[55],"14)":[57],"ramipril":[63,81,117,131,191,240],"(10":[64],"mg)":[65,83,195],"on":[66,222,231],"echocardiographic":[67],"measures":[68],"left":[70],"ventricular":[71],"(LV)":[72],"area":[73],"ejection":[75],"fraction":[76],"(EF).":[77],"An":[78],"early,":[79,129],"low-dose":[80,211],"(0.625":[82],"arm":[84],"was":[85,113,158,200],"also":[86],"evaluated.":[87],"Clinical":[88],"events":[89],"did":[90,163,213],"differ.":[92],"During":[93],"first":[95],"14":[96],"days,":[97],"risk":[99],"manifesting":[101],"systolic":[103],"arterial":[104],"pressure":[105],"<":[107,155],"or":[108],"=":[109],"90":[110],"mm":[111],"Hg":[112],"increased":[114,120],"both":[116],"groups.":[118],"LVEF":[119],"all":[122],"groups":[123],"during":[124],"this":[125],"period,":[126],"but":[127],"full-dose":[130,239],"group":[132,161],"had":[133,218],"greatest":[135],"improvement":[136],"EF":[138],"(increase:":[139],"full,":[140],"4.9":[141],"+/-":[142,146,150],"10.0;":[143],"low,":[144],"3.9":[145],"8.2%;":[147],"delayed,":[148],"2.4":[149],"8.8%;":[151],"P":[152],"for":[153],"trend":[154],".05)":[156],"only":[160,219],"that":[162,181],"demonstrate":[165],"significant":[167],"increase":[168],"LV":[170,197,223,232],"diastolic":[171],"area.":[172],"CONCLUSIONS:":[173],"The":[174,208,227],"results":[175,243],"present":[178],"study":[179],"demonstrated":[180,251],"use":[189,209,237],"(titrated":[192],"10":[194],"attenuated":[196],"remodeling":[198],"associated":[201],"prompter":[204],"recovery":[205],"LVEF.":[207],"regimen":[212],"prevent":[215],"hypotension":[216],"intermediate":[220],"benefits":[221],"size":[224],"function.":[226],"more":[228],"favorable":[229],"effects":[230],"topography":[233],"support":[241],"major":[246],"clinical":[247],"trials,":[248],"which":[249],"an":[252],"survival":[254],"benefit":[255],"inhibition.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}