{"id":"https://openalex.org/W2051773350","doi":"https://doi.org/10.1021/nl0731670","title":"Geometric Confinement Governs the Rupture Strength of H-bond Assemblies at a Critical Length Scale","display_name":"Geometric Confinement Governs the Rupture Strength of H-bond Assemblies at a Critical Length Scale","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W2051773350","doi":"https://doi.org/10.1021/nl0731670","mag":"2051773350","pmid":"https://pubmed.ncbi.nlm.nih.gov/18269263"},"language":"en","primary_location":{"id":"doi:10.1021/nl0731670","doi":"https://doi.org/10.1021/nl0731670","is_oa":false,"landing_page_url":"https://doi.org/10.1021/nl0731670","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014744105","display_name":"Sinan Keten","orcid":"https://orcid.org/0000-0003-2203-1425","observed_orcids":["https://orcid.org/0000-0003-2203-1425"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sinan Keten","raw_affiliation_strings":["Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue Room 1-272, Cambridge, Massachusetts","Massachusetts Institute Of Technology#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue Room 1-272, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute Of Technology#TAB#","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011504360","display_name":"Markus J. Buehler","orcid":"https://orcid.org/0000-0002-4173-9659","observed_orcids":["https://orcid.org/0000-0002-4173-9659"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus J. Buehler","raw_affiliation_strings":["Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue Room 1-272, Cambridge, Massachusetts","Massachusetts Institute Of Technology#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue Room 1-272, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute Of Technology#TAB#","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":7.4996,"has_fulltext":false,"cited_by_count":220,"citation_normalized_percentile":{"value":0.98372445,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"8","issue":"2","first_page":"743","last_page":"748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.1256999969482422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rupture-strength","display_name":"rupture strength","score":0.8410000205039978},{"id":"https://openalex.org/keywords/geometric-confinement","display_name":"confined geometries","score":0.9390000104904175},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.8830000162124634},{"id":"https://openalex.org/keywords/shear-strength","display_name":"shear strength","score":0.8090000152587891},{"id":"https://openalex.org/keywords/critical-length-scale","display_name":"critical length scale","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hydrogen-bond-clusters","display_name":"hydrogen bond clusters","score":0.7839999794960022},{"id":"https://openalex.org/keywords/protein-based-materials","display_name":"protein-based materials","score":0.5},{"id":"https://openalex.org/keywords/spider-silk","display_name":"spider silk","score":0.878000020980835},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nanocomposite-structure","display_name":"nanocomposite structure","score":0.7170000076293945},{"id":"https://openalex.org/keywords/explicit-solvent-model","display_name":"explicit solvent","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.5842519402503967},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5641413927078247},{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.5202428102493286},{"id":"https://openalex.org/C155860418","wikidata":"https://www.wikidata.org/wiki/Q863695","display_name":"Bond length","level":3,"score":0.519212543964386},{"id":"https://openalex.org/C159096172","wikidata":"https://www.wikidata.org/wiki/Q2914535","display_name":"Bond strength","level":4,"score":0.46676748991012573},{"id":"https://openalex.org/C11135259","wikidata":"https://www.wikidata.org/wiki/Q2477027","display_name":"Length scale","level":2,"score":0.4437214136123657},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3858274519443512},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.38203203678131104},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.37788230180740356},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30983006954193115},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.21717259287834167},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20443183183670044},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.19994154572486877},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.1648528277873993},{"id":"https://openalex.org/C68928338","wikidata":"https://www.wikidata.org/wiki/Q131790","display_name":"Adhesive","level":3,"score":0.13911223411560059},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/nl0731670","doi":"https://doi.org/10.1021/nl0731670","is_oa":false,"landing_page_url":"https://doi.org/10.1021/nl0731670","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},{"id":"pmid:18269263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18269263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1579363245","https://openalex.org/W1964441323","https://openalex.org/W1967158690","https://openalex.org/W2015011771","https://openalex.org/W2019877102","https://openalex.org/W2021189331","https://openalex.org/W2023108847","https://openalex.org/W2028811978","https://openalex.org/W2029860888","https://openalex.org/W2042445432","https://openalex.org/W2054256030","https://openalex.org/W2058912578","https://openalex.org/W2062611448","https://openalex.org/W2062818612","https://openalex.org/W2068049270","https://openalex.org/W2087514098","https://openalex.org/W2092454365","https://openalex.org/W2117243692","https://openalex.org/W2122171697","https://openalex.org/W2134932825","https://openalex.org/W2160839662","https://openalex.org/W4234689925"],"related_works":["https://openalex.org/W1977017316","https://openalex.org/W2056754062","https://openalex.org/W2261649583","https://openalex.org/W3148439838","https://openalex.org/W2171093204","https://openalex.org/W1992508492","https://openalex.org/W2055588916","https://openalex.org/W2091552954","https://openalex.org/W3006864225","https://openalex.org/W1991125158"],"abstract_inverted_index":{"The":[0,119],"ultrastructure":[1],"of":[2,16,20,23,28,60,72,84,89,130,144,152,156,163,187],"protein":[3],"materials":[4,47],"such":[5],"as":[6],"spider":[7],"silk,":[8],"muscle":[9],"tissue,":[10],"or":[11,44],"amyloid":[12],"fibers":[13],"consists":[14],"primarily":[15],"beta-sheets":[17],"structures,":[18],"composed":[19],"hierarchical":[21],"assemblies":[22,62],"H-bonds.":[24,90],"Despite":[25],"the":[26,57,110,140,150,161,181,185],"weakness":[27],"H-bond":[29,61,157],"interactions,":[30],"which":[31],"have":[32],"intermolecular":[33],"bonds":[34],"100":[35],"to":[36,96],"1000":[37],"times":[38],"weaker":[39],"than":[40],"those":[41],"in":[42,133,190],"ceramics":[43],"metals,":[45],"these":[46],"combine":[48],"exceptional":[49],"strength,":[50],"robustness,":[51],"and":[52,165,184],"resilience.":[53],"We":[54],"discover":[55],"that":[56,70,101,103],"rupture":[58],"strength":[59,99,113,142,183],"is":[63,121],"governed":[64],"by":[65,123,149],"geometric":[66],"confinement":[67],"effects,":[68],"suggesting":[69,177],"clusters":[71],"at":[73,114],"most":[74],"3-4":[75],"H-bonds":[76,108,145],"break":[77],"concurrently,":[78],"even":[79],"under":[80],"uniform":[81],"shear":[82,112,182],"loading":[83],"a":[85,115,153,178],"much":[86,166],"larger":[87,164],"number":[88],"This":[91],"universally":[92],"valid":[93],"result":[94],"leads":[95],"an":[97],"intrinsic":[98,141],"limitation":[100,143],"suggests":[102],"shorter":[104],"strands":[105],"with":[106],"less":[107],"achieve":[109],"highest":[111],"critical":[116],"length":[117],"scale.":[118],"hypothesis":[120],"confirmed":[122],"direct":[124],"large-scale":[125],"full-atomistic":[126],"MD":[127],"simulation":[128],"studies":[129],"beta-sheet":[131,168],"structures":[132],"explicit":[134],"solvent.":[135],"Our":[136,170],"finding":[137],"explains":[138],"how":[139],"can":[146],"be":[147],"overcome":[148],"formation":[151,162],"nanocomposite":[154],"structure":[155],"clusters,":[158],"thereby":[159],"enabling":[160],"stronger":[167],"structures.":[169],"results":[171],"explain":[172],"recent":[173],"experimental":[174],"proteomics":[175],"data,":[176],"correlation":[179],"between":[180],"prevalence":[186],"beta-strand":[188],"lengths":[189],"biology.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
