{"id":"https://openalex.org/W2051710000","doi":"https://doi.org/10.1007/s00253-006-0452-0","title":"Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug","display_name":"Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug","publication_year":2006,"publication_date":"2006-06-02","ids":{"openalex":"https://openalex.org/W2051710000","doi":"https://doi.org/10.1007/s00253-006-0452-0","mag":"2051710000","pmid":"https://pubmed.ncbi.nlm.nih.gov/16773335"},"language":"en","primary_location":{"id":"doi:10.1007/s00253-006-0452-0","doi":"https://doi.org/10.1007/s00253-006-0452-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00253-006-0452-0","pdf_url":null,"source":{"id":"https://openalex.org/S70979998","display_name":"Applied Microbiology and Biotechnology","issn_l":"0175-7598","issn":["0175-7598","1432-0614"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Microbiology and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://ir.ipe.ac.cn/handle/122111/3929","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014063639","display_name":"Chunzhao Liu","orcid":"https://orcid.org/0000-0002-1119-3448","observed_orcids":["https://orcid.org/0000-0002-1119-3448"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunzhao Liu","raw_affiliation_strings":["Graduate School of the Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. czliu@home.ipe.ac.cn","National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China. czliu@home.ipe.ac.cn","National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of the Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. czliu@home.ipe.ac.cn","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China. czliu@home.ipe.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]},{"raw_affiliation_string":"National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People\u2019s Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101646081","display_name":"Yan Zhao","orcid":"https://orcid.org/0000-0003-3779-1718","observed_orcids":["https://orcid.org/0000-0003-3779-1718"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":["Graduate School of the Chinese Academy of Sciences, Beijing, 100049, People's Republic of China","National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of the Chinese Academy of Sciences, Beijing, 100049, People's Republic of China","institution_ids":["https://openalex.org/I19820366"]},{"raw_affiliation_string":"National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100774051","display_name":"Yuchun Wang","orcid":"https://orcid.org/0000-0002-5864-2212","observed_orcids":["https://orcid.org/0000-0002-5864-2212"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuchun Wang","raw_affiliation_strings":["National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China. ycwang45@yahoo.com","National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China. ycwang45@yahoo.com","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]},{"raw_affiliation_string":"National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100080, People\u2019s Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014063639","https://openalex.org/A5100774051"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.7397,"has_fulltext":false,"cited_by_count":161,"citation_normalized_percentile":{"value":0.55887522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"72","issue":"1","first_page":"11","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.1298999935388565,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisinin","display_name":"artemisinin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/artemisia-annua","display_name":"Artemisia annua","score":1.0},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.9319999814033508},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cerebral-malaria","display_name":"cerebral malaria","score":0.9079999923706055},{"id":"https://openalex.org/keywords/artemisinin-biosynthesis","display_name":"artemisinin biosynthesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.6539999842643738},{"id":"https://openalex.org/keywords/genetic-engineering","display_name":"genetic engineering","score":0.8519999980926514},{"id":"https://openalex.org/keywords/in-vitro-tissue-culture","display_name":"in vitro tissue culture","score":0.843999981880188},{"id":"https://openalex.org/keywords/bioreactors","display_name":"bioreactors","score":0.8220000267028809},{"id":"https://openalex.org/keywords/plant-secondary-metabolites","display_name":"plant secondary metabolites","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.9943018555641174},{"id":"https://openalex.org/C2779691961","wikidata":"https://www.wikidata.org/wiki/Q1308044","display_name":"Artemisia annua","level":5,"score":0.9887489080429077},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7318625450134277},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.578176736831665},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.5269190669059753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.514698326587677},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5140622854232788},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46877187490463257},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.43024134635925293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07265782356262207}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031172","descriptor_name":"Artemisia annua","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D031172","descriptor_name":"Artemisia annua","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00253-006-0452-0","doi":"https://doi.org/10.1007/s00253-006-0452-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00253-006-0452-0","pdf_url":null,"source":{"id":"https://openalex.org/S70979998","display_name":"Applied Microbiology and Biotechnology","issn_l":"0175-7598","issn":["0175-7598","1432-0614"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Microbiology and Biotechnology","raw_type":"journal-article"},{"id":"pmid:16773335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16773335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied microbiology and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:ir.ipe.ac.cn:122111/3929","doi":null,"is_oa":true,"landing_page_url":"http://ir.ipe.ac.cn/handle/122111/3929","pdf_url":null,"source":{"id":"https://openalex.org/S7407064443","display_name":"Institute of Process Engineering, CAS Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"}],"best_oa_location":{"id":"pmh:oai:ir.ipe.ac.cn:122111/3929","doi":null,"is_oa":true,"landing_page_url":"http://ir.ipe.ac.cn/handle/122111/3929","pdf_url":null,"source":{"id":"https://openalex.org/S7407064443","display_name":"Institute of Process Engineering, CAS Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W52287702","https://openalex.org/W106949954","https://openalex.org/W168157087","https://openalex.org/W219333018","https://openalex.org/W263687841","https://openalex.org/W322931088","https://openalex.org/W1220601193","https://openalex.org/W1501079501","https://openalex.org/W1525232568","https://openalex.org/W1673362020","https://openalex.org/W1890673481","https://openalex.org/W1912698848","https://openalex.org/W1949440541","https://openalex.org/W1969962785","https://openalex.org/W1970333643","https://openalex.org/W1973472019","https://openalex.org/W1975126148","https://openalex.org/W1981720614","https://openalex.org/W1982706578","https://openalex.org/W1983005144","https://openalex.org/W1988086615","https://openalex.org/W1989468261","https://openalex.org/W1993254545","https://openalex.org/W1995368956","https://openalex.org/W1996036707","https://openalex.org/W1997110108","https://openalex.org/W2005092495","https://openalex.org/W2006265670","https://openalex.org/W2007742023","https://openalex.org/W2008678761","https://openalex.org/W2009571634","https://openalex.org/W2011221723","https://openalex.org/W2011894230","https://openalex.org/W2012232358","https://openalex.org/W2015000617","https://openalex.org/W2016348993","https://openalex.org/W2018085779","https://openalex.org/W2019281554","https://openalex.org/W2019423147","https://openalex.org/W2022750609","https://openalex.org/W2023533798","https://openalex.org/W2023542762","https://openalex.org/W2027305848","https://openalex.org/W2029346162","https://openalex.org/W2029365670","https://openalex.org/W2033004337","https://openalex.org/W2033721665","https://openalex.org/W2034019135","https://openalex.org/W2034553168","https://openalex.org/W2034796248","https://openalex.org/W2038664018","https://openalex.org/W2039794341","https://openalex.org/W2042768640","https://openalex.org/W2043764703","https://openalex.org/W2044444420","https://openalex.org/W2045037263","https://openalex.org/W2045056598","https://openalex.org/W2053210932","https://openalex.org/W2058023698","https://openalex.org/W2060458827","https://openalex.org/W2060857358","https://openalex.org/W2061459669","https://openalex.org/W2062825423","https://openalex.org/W2064354910","https://openalex.org/W2064909918","https://openalex.org/W2066899459","https://openalex.org/W2067042814","https://openalex.org/W2068064554","https://openalex.org/W2072042166","https://openalex.org/W2075736397","https://openalex.org/W2075920651","https://openalex.org/W2079682999","https://openalex.org/W2080892289","https://openalex.org/W2083000665","https://openalex.org/W2084397100","https://openalex.org/W2088241730","https://openalex.org/W2092423868","https://openalex.org/W2098184601","https://openalex.org/W2098390695","https://openalex.org/W2108002481","https://openalex.org/W2108488573","https://openalex.org/W2114731556","https://openalex.org/W2130482056","https://openalex.org/W2132259321","https://openalex.org/W2135680668","https://openalex.org/W2141596134","https://openalex.org/W2158661852","https://openalex.org/W2159307889","https://openalex.org/W2164660924","https://openalex.org/W2179640330","https://openalex.org/W2208924022","https://openalex.org/W2360900612","https://openalex.org/W2380345396","https://openalex.org/W2388035015","https://openalex.org/W2404204400","https://openalex.org/W2409232386","https://openalex.org/W2776801810","https://openalex.org/W2953222385","https://openalex.org/W2972999944","https://openalex.org/W2975978531","https://openalex.org/W2982267391","https://openalex.org/W3146961206"],"related_works":["https://openalex.org/W4229445725","https://openalex.org/W2064909918","https://openalex.org/W2322493375","https://openalex.org/W2123319365","https://openalex.org/W127670421","https://openalex.org/W4297902938","https://openalex.org/W2768973916","https://openalex.org/W4410344682","https://openalex.org/W2473639098","https://openalex.org/W140864706"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
